Acetazolamide in Treatment of Epilepsy

Evidence‐based Treatment of Idiopathic Generalized Epilepsies with Older Antiepileptic Drugs

“…The add‐on group showed similar results. This study demonstrated the problem of tolerance, which has been reported in other studies with AZM (31,32). Another study reported the addition of AZM to treat a group of 178 patients with seizures that included 14 patients with 30‐Hz spike‐and‐wave activity on EEG (33).…”

Evidence‐based Treatment of Idiopathic Generalized Epilepsies with Older Antiepileptic Drugs

“…The add‐on group showed similar results. This study demonstrated the problem of tolerance, which has been reported in other studies with AZM (31,32). Another study reported the addition of AZM to treat a group of 178 patients with seizures that included 14 patients with 30‐Hz spike‐and‐wave activity on EEG (33).…”

Acetazolamide as an effective treatment for pilomotor seizures in autoimmune encephalitis

“…Acetazolamide induces metabolic acidosis, increased neuronal [CO 2 ] and decreased glial and cerebral extracellular pH 6,9 . Hyperventilation, which causes a physiologic state opposite to that created by acetazolamide, 10,11 triggered temporal lobe seizures (subclinical or pilomotor) in five of six patients in this series.…”

“…Acetazolamide induces metabolic acidosis, increased neuronal [CO 2 ] and decreased glial and cerebral extracellular pH. 6,9 Hyperventilation, which causes a physiologic state opposite to that created by acetazolamide, 10,11 five of six patients in this series. The by which hyperventilation can potentiate seizures is not fully understood but is hypothesized to be related to pH changes.…”

Acetazolamide in Women with Catamenial Epilepsy

“…This led to the hypothesis that the anticonvulsant properties of AZM may be due to its diuretic effect. However, Ansell and Clarke (17) found no significant differences in body weight, sodium metabolism, or total body water between 14 epileptic women and 10 healthy controls or women with and without catamenial seizures treated with AZM.…”

“…Poser (35) reported an anectodal improvement in seizures without adverse effects in women treated with 250 mg once or twice daily for 5-7 days before and during menses. Ansell et al (17) reported marked benefit in two subjects treated with 5 mg/kg/day for 3 days surrounding menses. A diuretic effect was the proposed mechanism of action.…”

Evidence‐based Treatment of Idiopathic Generalized Epilepsies with Older Antiepileptic Drugs

“…The add‐on group showed similar results. This study demonstrated the problem of tolerance, which has been reported in other studies with AZM (31,32). Another study reported the addition of AZM to treat a group of 178 patients with seizures that included 14 patients with 30‐Hz spike‐and‐wave activity on EEG (33).…”

Acetazolamide as an effective treatment for pilomotor seizures in autoimmune encephalitis

“…Acetazolamide induces metabolic acidosis, increased neuronal [CO 2 ] and decreased glial and cerebral extracellular pH 6,9 . Hyperventilation, which causes a physiologic state opposite to that created by acetazolamide, 10,11 triggered temporal lobe seizures (subclinical or pilomotor) in five of six patients in this series.…”

“…Acetazolamide induces metabolic acidosis, increased neuronal [CO 2 ] and decreased glial and cerebral extracellular pH. 6,9 Hyperventilation, which causes a physiologic state opposite to that created by acetazolamide, 10,11 five of six patients in this series. The by which hyperventilation can potentiate seizures is not fully understood but is hypothesized to be related to pH changes.…”

Acetazolamide in Women with Catamenial Epilepsy

“…This led to the hypothesis that the anticonvulsant properties of AZM may be due to its diuretic effect. However, Ansell and Clarke (17) found no significant differences in body weight, sodium metabolism, or total body water between 14 epileptic women and 10 healthy controls or women with and without catamenial seizures treated with AZM.…”

“…Poser (35) reported an anectodal improvement in seizures without adverse effects in women treated with 250 mg once or twice daily for 5-7 days before and during menses. Ansell et al (17) reported marked benefit in two subjects treated with 5 mg/kg/day for 3 days surrounding menses. A diuretic effect was the proposed mechanism of action.…”

Evidence‐based Treatment of Idiopathic Generalized Epilepsies with Older Antiepileptic Drugs

“…The add‐on group showed similar results. This study demonstrated the problem of tolerance, which has been reported in other studies with AZM (31,32). Another study reported the addition of AZM to treat a group of 178 patients with seizures that included 14 patients with 30‐Hz spike‐and‐wave activity on EEG (33).…”

Acetazolamide as an effective treatment for pilomotor seizures in autoimmune encephalitis

“…Acetazolamide induces metabolic acidosis, increased neuronal [CO 2 ] and decreased glial and cerebral extracellular pH 6,9 . Hyperventilation, which causes a physiologic state opposite to that created by acetazolamide, 10,11 triggered temporal lobe seizures (subclinical or pilomotor) in five of six patients in this series.…”

“…Acetazolamide induces metabolic acidosis, increased neuronal [CO 2 ] and decreased glial and cerebral extracellular pH. 6,9 Hyperventilation, which causes a physiologic state opposite to that created by acetazolamide, 10,11 five of six patients in this series. The by which hyperventilation can potentiate seizures is not fully understood but is hypothesized to be related to pH changes.…”

Acetazolamide in Women with Catamenial Epilepsy

“…This led to the hypothesis that the anticonvulsant properties of AZM may be due to its diuretic effect. However, Ansell and Clarke (17) found no significant differences in body weight, sodium metabolism, or total body water between 14 epileptic women and 10 healthy controls or women with and without catamenial seizures treated with AZM.…”

“…Poser (35) reported an anectodal improvement in seizures without adverse effects in women treated with 250 mg once or twice daily for 5-7 days before and during menses. Ansell et al (17) reported marked benefit in two subjects treated with 5 mg/kg/day for 3 days surrounding menses. A diuretic effect was the proposed mechanism of action.…”