“…We have reexamined the effect of acetazolamide on CBF and although we observed an increase, it was consistently less than the large increases in CBF others have reported (1)(2)(3)(4)(5)(6)(7). This apparent discrepancy prompted us to measure the effect of acetazolamide on the CMRO2 because the reported CBF changes after intravenous acetazolamide (Table I) are based, in large measure, on the use of the brain arteriovenous oxygen difference as an index of CBF.…”