The Effect of Acetazolamide on Cerebral Blood Flow and Oxygen Utilization in the Rhesus Monkey

Effects of Acetazolamide on Cerebral Blood Flow, Blood Volume, and Oxygen Metabolism: A Positron Emission Tomography Study with Healthy Volunteers

“…Bickler et al (1988) reported the difference in pH and PCO 2 in the brain tissue compared with peripheral PaCO 2 , indicating that carbonic acidosis induced an increase in tissue or capillary PaCO 2 after ACZ administration, which caused the increase in rCBF. Our results are consistent with their report because no change in arterial PaCO 2 was observed after ACZ administration, supporting the conclusion that the increase in CBF was not due to a systemic increase in carbon dioxide tension, as reported by Laux et al (1978). The lack of changes in systemic physiologic variables including PaCO 2 , pH, blood pressure and arterial O 2 content, were also consistent with other reports (Vorstrup et al, 1986;Piepgras et al, 1990;Inao et al, 1998).…”

Effects of Acetazolamide on Cerebral Blood Flow, Blood Volume, and Oxygen Metabolism: A Positron Emission Tomography Study with Healthy Volunteers

“…Bickler et al (1988) reported the difference in pH and PCO 2 in the brain tissue compared with peripheral PaCO 2 , indicating that carbonic acidosis induced an increase in tissue or capillary PaCO 2 after ACZ administration, which caused the increase in rCBF. Our results are consistent with their report because no change in arterial PaCO 2 was observed after ACZ administration, supporting the conclusion that the increase in CBF was not due to a systemic increase in carbon dioxide tension, as reported by Laux et al (1978). The lack of changes in systemic physiologic variables including PaCO 2 , pH, blood pressure and arterial O 2 content, were also consistent with other reports (Vorstrup et al, 1986;Piepgras et al, 1990;Inao et al, 1998).…”

Acute effects of acetazolamide on cerbral blood flow in man

“…One should then expect increased PaCOz du to COz retention and lower PACOz due to increased ventilation. Such an increase in the PaCOIPACOz gap is well documented after doses greater than 15 mgikg of acetazolamide (Pocidalo et al 1960, Cain & Otis 1961, Laux & Raichle 1978. Burton et al (1960) and Swenson & Maren (1978) however, reported unchanged blood gas values and ventilation after doses comparable to ours.…”

Drug Effects on Cerebral Blood Flow in the Baboon Model - Acetazolamide and Nimodipine

“…It is interesting to note that the increased cerebral blood flow observed for acetazolamide and nimodipine alone individually is great-ly diminished when the drugs are combined. These results strongly support the suggestion that acetazolamide may have an effect on the local cerebral metabolic rate for oxygen (13,20). They may further indicate that the cerebral vasodilatory properties of acetazolamide are unrelated to its carbonic anhydrase inhibition.…”

Effects of Acetazolamide on Cerebral Blood Flow, Blood Volume, and Oxygen Metabolism: A Positron Emission Tomography Study with Healthy Volunteers

“…Bickler et al (1988) reported the difference in pH and PCO 2 in the brain tissue compared with peripheral PaCO 2 , indicating that carbonic acidosis induced an increase in tissue or capillary PaCO 2 after ACZ administration, which caused the increase in rCBF. Our results are consistent with their report because no change in arterial PaCO 2 was observed after ACZ administration, supporting the conclusion that the increase in CBF was not due to a systemic increase in carbon dioxide tension, as reported by Laux et al (1978). The lack of changes in systemic physiologic variables including PaCO 2 , pH, blood pressure and arterial O 2 content, were also consistent with other reports (Vorstrup et al, 1986;Piepgras et al, 1990;Inao et al, 1998).…”

Acute effects of acetazolamide on cerbral blood flow in man

“…One should then expect increased PaCOz du to COz retention and lower PACOz due to increased ventilation. Such an increase in the PaCOIPACOz gap is well documented after doses greater than 15 mgikg of acetazolamide (Pocidalo et al 1960, Cain & Otis 1961, Laux & Raichle 1978. Burton et al (1960) and Swenson & Maren (1978) however, reported unchanged blood gas values and ventilation after doses comparable to ours.…”

Drug Effects on Cerebral Blood Flow in the Baboon Model - Acetazolamide and Nimodipine

“…It is interesting to note that the increased cerebral blood flow observed for acetazolamide and nimodipine alone individually is great-ly diminished when the drugs are combined. These results strongly support the suggestion that acetazolamide may have an effect on the local cerebral metabolic rate for oxygen (13,20). They may further indicate that the cerebral vasodilatory properties of acetazolamide are unrelated to its carbonic anhydrase inhibition.…”

Effects of Acetazolamide on Cerebral Blood Flow, Blood Volume, and Oxygen Metabolism: A Positron Emission Tomography Study with Healthy Volunteers

“…Bickler et al (1988) reported the difference in pH and PCO 2 in the brain tissue compared with peripheral PaCO 2 , indicating that carbonic acidosis induced an increase in tissue or capillary PaCO 2 after ACZ administration, which caused the increase in rCBF. Our results are consistent with their report because no change in arterial PaCO 2 was observed after ACZ administration, supporting the conclusion that the increase in CBF was not due to a systemic increase in carbon dioxide tension, as reported by Laux et al (1978). The lack of changes in systemic physiologic variables including PaCO 2 , pH, blood pressure and arterial O 2 content, were also consistent with other reports (Vorstrup et al, 1986;Piepgras et al, 1990;Inao et al, 1998).…”

Acute effects of acetazolamide on cerbral blood flow in man

“…One should then expect increased PaCOz du to COz retention and lower PACOz due to increased ventilation. Such an increase in the PaCOIPACOz gap is well documented after doses greater than 15 mgikg of acetazolamide (Pocidalo et al 1960, Cain & Otis 1961, Laux & Raichle 1978. Burton et al (1960) and Swenson & Maren (1978) however, reported unchanged blood gas values and ventilation after doses comparable to ours.…”

Drug Effects on Cerebral Blood Flow in the Baboon Model - Acetazolamide and Nimodipine

“…It is interesting to note that the increased cerebral blood flow observed for acetazolamide and nimodipine alone individually is great-ly diminished when the drugs are combined. These results strongly support the suggestion that acetazolamide may have an effect on the local cerebral metabolic rate for oxygen (13,20). They may further indicate that the cerebral vasodilatory properties of acetazolamide are unrelated to its carbonic anhydrase inhibition.…”