Diamine Oxidase (Histaminase) and Heparin Inhibition of Gastric Secretion in Man

Hansson, R.; Sundström, Gunnar

doi:10.3109/00365517009046232

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…The infusion of exogenous DAO made from pig kidney inhibited histamine-induced gastric acid secretion in dogs ( 138 ). In a human study, heparin-induced gastric acid inhibition was mediated by endogenous DAO ( 151 ).…”

Section: Regulation Of Gastric Acid Secretionmentioning

confidence: 99%

The Physiology of the Gastric Parietal Cell

Engevik

Kaji

Goldenring

2020

Physiological Reviews

157

103

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Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food, absorption of minerals, and control of harmful bacteria. However, a fine balance of activators and inhibitors of parietal cell-mediated acid secretion is required to ensure proper digestion of food, while preventing damage to the gastric and duodenal mucosa. As a result, parietal cell secretion is highly regulated through numerous mechanisms including the vagus nerve, gastrin, histamine, ghrelin, somatostatin, glucagon-like peptide 1, and other agonists and antagonists. The tight regulation of parietal cells ensures the proper secretion of HCl. The H+-K+-ATPase enzyme expressed in parietal cells regulates the exchange of cytoplasmic H+ for extracellular K+. The H+ secreted into the gastric lumen by the H+-K+-ATPase combines with luminal Cl− to form gastric acid, HCl. Inhibition of the H+-K+-ATPase is the most efficacious method of preventing harmful gastric acid secretion. Proton pump inhibitors and potassium competitive acid blockers are widely used therapeutically to inhibit acid secretion. Stimulated delivery of the H+-K+-ATPase to the parietal cell apical surface requires the fusion of intracellular tubulovesicles with the overlying secretory canaliculus, a process that represents the most prominent example of apical membrane recycling. In addition to their unique ability to secrete gastric acid, parietal cells also play an important role in gastric mucosal homeostasis through the secretion of multiple growth factor molecules. The gastric parietal cell therefore plays multiple roles in gastric secretion and protection as well as coordination of physiological repair.

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Section: Regulation Of Gastric Acid Secretionmentioning

confidence: 99%

The Physiology of the Gastric Parietal Cell

Engevik

Kaji

Goldenring

2020

Physiological Reviews

157

103

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“…In rats the enzyme was found to be present in most of the stomachs investigated [1][2][3][4], but in the gastric mucosa of guinea pigs, rabbits, cats, dogs and human subjects no diamine oxidase at all [2,[5][6][7] In contrast to these results, however, were some observations indicating most likely the occurrence of diamine oxidase in gastric mucosa. Since acid secretion could be inhibited by intravenous infusion of diamine oxidase in dogs [1,[9][10][11] or by heparin induced release of diamine oxidase in man [12], it was interesting to note that this secretory process was increased by the administration of diamine oxidase inhibitors such as B 1-pyrimidine and aminoguanidine in rats, cats and dogs [1,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Diamine oxidase activity in gastric and duodenal mucosa of man and other mammals with special reference to the pyloric junction

et al. 1978

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In the gastric mucosa of human subjects and of various mammals methylation was accepted as the main pathway of histamine catabolism. However, augmentation of gastric acid secretion by aminoguanidine, the strong inhibitor of diamine oxidase, indicated an influence of diamine oxidase activity on this secretory process. Therefore a careful reinvestigation of the occurrence of diamine oxidase activity was started from the distal duodenum in the direction of the cardia. In all species studied, diamine oxidase activity decreased from distal duodenum towards the pylorus. In dogs, landrace pigs and in human subjects the diamine oxidase activity clearly exceeded the pyloric borderline gradually becoming zero in corpus or fundus. In rabbits, however, and especially in mini-pigs no diamine oxidase activity was found beyond the pylorus. Among individuals gastric diamine oxidase activity showed a variable prevalence and could not be found regularly in all the subjects. In one patient with prepyloric ulcer a strong influence of pathophysiological processes on gastric diamine oxidase activity could be suspected. Thus, in every alteration of the gastric mucosa under experimental or clinical conditions also an alteration of gastric diamine oxidase activity should be taken into account.

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Redefining Clinical Research

Kovacs

1985

Lung Cancer

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Diamine Oxidase (Histaminase) and Heparin Inhibition of Gastric Secretion in Man

Cited by 6 publications

References 9 publications

The Physiology of the Gastric Parietal Cell

The Physiology of the Gastric Parietal Cell

Diamine oxidase activity in gastric and duodenal mucosa of man and other mammals with special reference to the pyloric junction

Redefining Clinical Research

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