Redefining Clinical Research

Kovacs, C. J.

doi:10.1007/978-3-642-82234-6_8

Cited by 3 publications

(1 citation statement)

References 97 publications

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“…With so many varieties of stars which exhibit clear signatures of enhancements of the s-process in their abundance patterns, it is not surprising that a great deal of effort has been expended by observational spectroscopists in analyzing the details of s-process nucleosynthesis in the heavy-element rich stars. A number of detailed abundance analyses have been conducted on the various heavy-element rich stars over the last 15 years and can be summarized as follows: for the barium giants we have Tomkin & Lambert (1983, 1986, Smith (1984), AGB star photospheres 71 Kovacs (1985), Smith & Lambert (1984), Malaney & Lambert (1988), , while the main-sequence Ba stars have been studied by Tomkin et al (1989) and North et al (1994). The CH giants have been studied by Vanture (1992aVanture ( , 1992b.…”

Section: Vv Smithmentioning

confidence: 99%

The Analysis of AGB Star Photospheres

Smith

1999

Symp. - Int. Astron. Union

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The presence of excess 12C, 13C, 14N, Li, and the heavy s-process elements in the photospheres of AGB stars betray the operation of Eland 4He-burning, hot-bottom burning, and slow neutron-capture nucleosynthesis. Careful abundance analyses of these various elements provides insight into both nucleosynthesis events and mixing processes which occur deep within the AGB star. Recent results for the s-process are discussed.

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Section: Vv Smithmentioning

confidence: 99%

The Analysis of AGB Star Photospheres

Smith

1999

Symp. - Int. Astron. Union

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Absence of interleukin 1α radioprotection in tumor-bearing animals: elevated plasma levels of prostaglandin E versus a preexisting primed marrow

Kovacs

Harrell

Evans

et al. 1992

Journal of Leukocyte Biology

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Recombinant human interleukin 1 (IL-1) administered as a "priming" agent 24 h prior to hematopoietically lethal doses of total body irradiation (TBI) confers radioprotection to normal C57B1/6 (B6) mice, but not to B6 tumor-bearing animals (TBAs) known to have altered hematopoietic steady states. Using the Lewis lung tumor (LLca) in the B6 mouse, studies were carried out to determine whether the failure of IL-1 to radioprotect the LLca TBA was related to a preexisting "primed" hematopoietic state in the TBA or resulted from inhibition of myelopoietic activity associated with the production of prostaglandin E (PGE) by, or in response to, the tumor. Both normal B6 and LLca B6 TBAs were injected (every 24 h x 1-5) with 100 micrograms of indomethacin (IND) prior to the administration of IL-1. A single treatment with IND was sufficient to reduce the elevated levels of PGE found in the plasma of the TBAs. After five treatments, IND reduced the PGE level to below that of controls. Neither the acute nor the protracted IND treatment, however, affected the expansion of the stem and progenitor cell compartments of the marrow in the LLca TBA. Furthermore, no evidence of restoration of the radioprotective properties of IL-1 was observed in TBAs pretreated with IND. Collectively, these data suggest that the failure of IL-1 to provide radioprotection to the LLca TBA is not a direct result of the elevated plasma PGE levels associated with growth of the LLca tumor. In addition, these studies provide insight into the importance of examining in vivo effects of biological molecules in altered, as well as normal, physiological states.

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Accelerated Postirradiation Recovery of Hematopoietic Marrow Following Priming with Low Doses of Vincristine

Johnke¹,

Abernathy²

1990

Radiation Research

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The present investigation is a continuation of efforts to characterize the radioprotective potential of priming with vincristine (VcR). In this study, the postirradiation recovery kinetics of the marrow's hematopoietic stem cell, progenitor cell, and stromal cell compartments were monitored following exposure to a range of sublethal radiation doses to determine (a) the optimal VcR/radiation intertreatment interval for achieving maximal hematopoietic protection, (b) whether this optimal interval is influenced by the dose of radiation administered, and (c) whether the radioprotection observed involves the hematopoietic stroma. The results demonstrate that the degree of radioprotection observed was significantly influenced by the scheduling of the VcR priming dose with respect to the radiation exposure. An intertreatment interval of 24 h provided maximal radioprotective benefit irrespective of the radiation dose administered. Additionally, the radioprotection following VcR priming appeared to be more the result of an accelerated recovery in the hematopoietic stem cell and progenitor cell compartments than a change in their intrinsic radiosensitivity. The data also suggest that this accelerated recovery was not a consequence of greater radioprotection of marrow stroma. Finally, the radioprotection observed following VcR priming did not appear to involve a selective lineage response by either the erythroid or the granulomonocytic progenitor compartments.

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Redefining Clinical Research

Cited by 3 publications

References 97 publications

The Analysis of AGB Star Photospheres

The Analysis of AGB Star Photospheres

Absence of interleukin 1α radioprotection in tumor-bearing animals: elevated plasma levels of prostaglandin E versus a preexisting primed marrow

Accelerated Postirradiation Recovery of Hematopoietic Marrow Following Priming with Low Doses of Vincristine

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