Diallyl sulfide inhibits the induction of HPRT‐deficient mutants in chinese hamster V79 cells treated with dimethylnitrosoamine in the presence of S‐9 of rats induced with acetone

Fiorio, R.; Bronzetti, G.

doi:10.1002/em.2850250413

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…For instance, entering the terms ''isothiocyanates'' and ''allyl sulfides'' into PubMed resulted in 10,282 and 600 citations, respectively. This journal lists several papers on the topic, describing the antimutagenic effects of garlic extract in the Salmonella assay and in Chinese hamster ovary cells [Knasmuller et al, 1989]; the anticlastogenic properties of garlic extract in mice given mitomycin C, cyclophosphamide, or sodium arsenite [Das et al, 1993]; the protection by Brassica campestris mustard leaf towards chromosomal damage and oxidative stress induced by g-radia-tion, cyclophosphamide, and urethane in mice [Tiku et al, 2008]; the inhibitory effects of diallyl sulfide in Chinese hamster V79 cells treated with dimethylnitrosamine [Fiorio and Bronzetti, 1995]; and the antigenotoxic activity of sulforaphane (SFN) in cultured human lymphocytes treated with ethyl methanesulfonate, vincristrine, H 2 O 2 , and mitomycin C [Fimognari et al, 2005].…”

Section: Introductionmentioning

confidence: 99%

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds

Nian

Delage

et al. 2009

Environ and Mol Mutagen

173

129

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Histone deacetylase (HDAC) inhibitors reactivate epigenetically-silenced genes in cancer cells, triggering cell cycle arrest and apoptosis. Recent evidence suggests that dietary constituents can act as HDAC inhibitors, such as the isothiocyanates found in cruciferous vegetables and the allyl compounds present in garlic. Broccoli sprouts are a rich source of sulforaphane (SFN), an isothiocyanate that is metabolized via the mercapturic acid pathway and inhibits HDAC activity in human colon, prostate, and breast cancer cells. In mouse preclinical models, SFN inhibited HDAC activity and induced histone hyperacetylation coincident with tumor suppression. Inhibition of HDAC activity also was observed in circulating peripheral blood mononuclear cells obtained from people who consumed a single serving of broccoli sprouts. Garlic organosulfur compounds can be metabolized to allyl mercaptan (AM), a competitive HDAC inhibitor that induced rapid and sustained histone hyperacetylation in human colon cancer cells. Inhibition of HDAC activity by AM was associated with increased histone acetylation and Sp3 transcription factor binding to the promoter region of the P21WAF1 gene, resulting in elevated p21 protein expression and cell cycle arrest. Collectively, the results from these studies, and others reviewed herein, provide new insights into the relationships between reversible histone modifications, diet, and cancer chemoprevention.

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