Antimutagenicity of sodium selenite in Chinese hamster V79 cells exposed to azoxymethane, methylmethansulphonate and hydrogen peroxide

Bronzetti, G.

doi:10.1016/s0027-5107(02)00318-4

Cited by 20 publications

(9 citation statements)

References 34 publications

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“…They attributed this to the toxic effects of such compounds. In 2003, Bronzetti et al (2003) investigated the antimutagenicity of sodium selenite in Chinese hamster V79 cells exposed to azoxymethane, methylmethanesulphonate, and H 2 O 2 . They found that Se reduced the genotoxic effect of the aforementioned mutagens and carcinogens.…”

Section: Resultsmentioning

confidence: 99%

Antimutagenic activities of two suspected anticarcinogenic bifunctional organoiron seleno-terephthalate derivatives

Maslat

Jibril

Mizyed

2010

Drug and Chemical Toxicology

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Two newly bifunctional organoiron seleno-terephthalate derivatives (S1 and S2) were synthesized as potential anticarcinogenic compounds. In a previous study, they were found to have antibacterial and/or antifungal activity, while they did not show any mutagenic action. Such compounds were investigated in the present study for their antimutagenic activity. Sodium azide, hydrogen peroxide, and 4-nitro-o-phenylenediamine, as known mutagens for strains TA100, TA102, and TA98 of Salmonella typhimurium, respectively, were used. Both (S1 and S2) compounds showed a strong antimutagenic action of >98% against sodium azide, >70% against hydrogen peroxide, and >65% activity against 4-nitro-o-phenylenediamine. Bearing in mind the strong correlation between mutagenicity and carcinogenicity, the above compounds can be considered as potentially promising anticarcinogens. Therefore, the present results are very encouraging to investigate the above compounds for other biological activities, including their evaluation as anticarcinogens. A suggested mechanism for the antimutagenicity of the tested compounds is presented.

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Section: Resultsmentioning

confidence: 99%

Antimutagenic activities of two suspected anticarcinogenic bifunctional organoiron seleno-terephthalate derivatives

Maslat

Jibril

Mizyed

2010

Drug and Chemical Toxicology

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“…The genotoxic effect of reactive oxygen species has been documented in V79 cells, causing DNAstrand breakage and base modification. 33) Hydrogen peroxide is converted to the hydroxyl radical that causes oxidative damage close to the site of its formation.…”

Section: Discussionmentioning

confidence: 99%

Influence of <i>Styrax camporum</i> and of Chemical Markers (Egonol and Homoegonol) on DNA Damage Induced by Mutagens with Different Mechanisms of Action

Oliveira

Damasceno

Nicolella

et al. 2016

Biological & Pharmaceutical Bulletin

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“…H 2 O 2 is a potent genotoxin, able to induce oxidative DNA damage, including DNA‐strand breakage and base modification. The genotoxic effect of ROS, in particular H 2 O 2 that induces lesions similar to those resulting from ionizing radiation, has been well documented in V79 cells (Bronzetti and others 2003). H 2 O 2 is converted to the hydroxyl radical which is expected, due to its high reactivity, to cause oxidative damage close to the site of its formation (Wiseman and Halliwell 1996).…”

Section: Discussionmentioning

confidence: 99%

Baccharin Prevents Genotoxic Effects Induced by Methyl Methanesulfonate and Hydrogen Peroxide in V79 Cells

Oliveira

Leandro

Montanheiro

et al. 2012

Journal of Food Science

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Baccharin is one of the major chemical compounds isolated from the aerial parts of Baccharis dracunculifolia DC (Asteraceae), a native plant of South America and the most important botanical source of the Brazilian green propolis that has been used in alternative medicine to treat inflammation, liver disorders, and stomach ulcers. The present study was carried out in V79 cells to determine the possible genotoxic and antigenotoxic activities of baccharin utilizing comet and micronucleus assays, where 2 known mutagenic agents with different mechanisms of DNA damage were used as positive controls. The V79 cells were treated with concentrations of baccharin (0.25, 0.5, 1.0, and 2.0 μg/mL) and for to investigate the antigenotoxicity these concentrations were associated with methyl methanesulfonate (MMS; 200 μM-comet assay and 400 μM-micronucleus assay) or hydrogen peroxide (H(2)O(2;) 50 μM-comet assay and 100 μM-micronucleus assay). Statistically significant differences in the rate of DNA damage were observed in cultures treated with the highest concentration of baccharin when compared to the control group, but this difference was not found in the micronucleus assay. The results also showed that the frequencies of DNA damage and micronuclei induced by MMS and H(2)O(2) were significantly reduced after treatment with baccharin. The baccharin showed a chemoprevention effect and can be the chemical compound responsible for the antigenotoxicity also demonstrated by the B. dracunculifolia. The antioxidant potential of baccharin may be related to its chemoprevention activity induced against both genomic and chromosomal damages.

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Antimutagenicity of sodium selenite in Chinese hamster V79 cells exposed to azoxymethane, methylmethansulphonate and hydrogen peroxide

Cited by 20 publications

References 34 publications

Antimutagenic activities of two suspected anticarcinogenic bifunctional organoiron seleno-terephthalate derivatives

Antimutagenic activities of two suspected anticarcinogenic bifunctional organoiron seleno-terephthalate derivatives

Influence of <i>Styrax camporum</i> and of Chemical Markers (Egonol and Homoegonol) on DNA Damage Induced by Mutagens with Different Mechanisms of Action

Baccharin Prevents Genotoxic Effects Induced by Methyl Methanesulfonate and Hydrogen Peroxide in V79 Cells

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