Antimutagenic activities of two suspected anticarcinogenic bifunctional organoiron seleno-terephthalate derivatives

Abstract

Two newly bifunctional organoiron seleno-terephthalate derivatives (S1 and S2) were synthesized as potential anticarcinogenic compounds. In a previous study, they were found to have antibacterial and/or antifungal activity, while they did not show any mutagenic action. Such compounds were investigated in the present study for their antimutagenic activity. Sodium azide, hydrogen peroxide, and 4-nitro-o-phenylenediamine, as known mutagens for strains TA100, TA102, and TA98 of Salmonella typhimurium, respectively, were used. Both (S1 and S2) compounds showed a strong antimutagenic action of >98% against sodium azide, >70% against hydrogen peroxide, and >65% activity against 4-nitro-o-phenylenediamine. Bearing in mind the strong correlation between mutagenicity and carcinogenicity, the above compounds can be considered as potentially promising anticarcinogens. Therefore, the present results are very encouraging to investigate the above compounds for other biological activities, including their evaluation as anticarcinogens. A suggested mechanism for the antimutagenicity of the tested compounds is presented.

Cyclopentadienyl iron dicarbonyl styrene chalcogenosulfonates: synthesis and structure of CpFe(CO)2SeSO2CH=CHPh

“…12 Iron selenocarboxylates show antifungal, antibacterial effects and are active substrates against cancer cells. 14,15 In the past two decades, we have developed a synthetic methodology for iron complexes of the general formula CpFe(CO) 2 EQ (E= S, Se, Q= COR, 16,17 SO 2 R, 18,19 COCO 2 R, 20 CO 2 R, 21,22 C(S)OR, 23,24 C(O) SR, 25,26 CS 2 R 27 ). This methodology involves the interaction of iron sulfides or selenide bridged dimers (l-E x )[CpFe(CO) 2 ] 2 (E = S, x = 2-4; E = Se, x = 1) with the corresponding chlorides (QCl).…”

Novel 2-Hydroselenonicotinonitriles and Selenopheno[2, 3-b]pyridines: Efficient Synthesis, Molecular Docking-DFT Modeling, and Antimicrobial Assessment

“…Many studies described the antimicrobial activity of selenium containing compounds specifically against several strains of bacteria causing nosocomial infections or forming biofilm, such as Escherichia coli and Staphylococcus aureus (Mosolygó et al, 2019). Moreover, selenium containing heterocyclic compounds are well-known for their antibacterial, antifungal, antiviral, antioxidant, antiinflammatory, antileishmanial, and antimutagenic properties (Leyck and Parnham, 1990;Tapiero et al, 2003;Al-Smadi and Al-Momani, 2008;Maslat et al, 2010;Díaz et al, 2019;Spengler et al, 2019).…”