Organosulfur Compounds and Cancer

Lea, Michael A.

doi:10.1007/978-1-4613-0399-2_12

Cited by 19 publications

(11 citation statements)

References 38 publications

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“…Recent data convincingly pointed out that garlic has a wide range of biological activities against a number of chronic diseases, including cardiovascular disorders, diabetes, infections, and other metabolic ills as well as cancer (Khatua et al 2013;Padiya and Banerjee 2013;Trio et al 2014). Garlic is a particularly rich source of organosulfur compounds (OSCs), and diallyl monosulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS) are the most abundant compounds in garlic oil (Lea 1996;Amagase et al 2001;Iciek et al 2009). The antioxidant potential is in the order DATS > DADS > DAS (Chen et al 2004;Fukao et al 2004;Jakubíková and Sedlák 2006;Liu et al 2014), suggesting that the number of sulfur atoms plays a vital role in the biological activities of OSCs.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative effects of diallyl trisulfide on hydrogen peroxide-induced cytotoxicity through regulation of nuclear factor-E2-related factor-mediated thioredoxin reductase 1 expression in C2C12 skeletal muscle myoblast cells

Kang

Kim²,

Kim³

et al. 2017

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Diallyl trisulfide (DATS) is one of the major sulfur-containing compounds in garlic oil. In this study, we analyzed the effects of DATS against hydrogen peroxide (H2O2)-induced oxidative stress in C2C12 myoblasts. DATS preconditioning significantly attenuated H2O2-induced growth inhibition and DNA damage, as well as apoptosis by decreasing the generation of ROS. Treatment with DATS alone effectively upregulated the expression of nuclear factor-erythroid 2-related factor 2 (Nrf2) and thioredoxin reductase 1 (TrxR1), which was associated with the increased phosphorylation of Nrf2. However, the protective effects of DATS against H2O2-induced growth reduction and ROS accumulation were significantly abolished by auranofin, an inhibitor of TrxR activity. Moreover, DATS-mediated phosphorylation of Nrf2 and induction of TrxR1 were markedly reduced by genetic silencing of Nrf2. DATS treatment also induced the phosphorylation extracellular signal-regulating kinase (ERK), and analysis using specific inhibitors of cellular signaling pathways demonstrated that only ERK activation was involved in Nrf2 phosphorylation and TrxR1 induction. In addition, the cytoprotective potentials were abrogated in C2C12 cells pretreated with an ERK specific inhibitor. The results demonstrate that DATS protects against oxidative stress-induced DNA damage and apoptosis in C2C12 cells in part through the activation of Nrf2-mediated TrxR1 induction via the ERK signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Antioxidative effects of diallyl trisulfide on hydrogen peroxide-induced cytotoxicity through regulation of nuclear factor-E2-related factor-mediated thioredoxin reductase 1 expression in C2C12 skeletal muscle myoblast cells

Kang

Kim²,

Kim³

et al. 2017

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“…In this regard the potential chemopreventive effect of garlic (Allium sativum) was subject of various clinical trials (Dorant et al, 1993;Steinmetz et al, 1994;Agarwal, 1996;Dorant et al, 1996;Koch and Lawson, 1996;Lea, 1996;Milner, 1996). The results, however, were quite contradictory depending on the type of tumor examined and the garlic preparation used (Dorant et al, 1993).…”

mentioning

confidence: 99%

Ajoene, a Compound of Garlic, Induces Apoptosis in Human Promyeloleukemic Cells, Accompanied by Generation of Reactive Oxygen Species and Activation of Nuclear Factor κB

Dirsch¹,

Gerbes²,

Vollmar³

1998

Mol Pharmacol

185

111

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The pharmacological role of garlic in prevention and treatment of cancer has received increasing attention, but thorough investigations into the molecular mechanisms of action of garlic compounds are rare. The present study demonstrates that ajoene, a major compound of garlic induces apoptosis in human leukemic cells, but not in peripheral mononuclear blood cells of healthy donors. The effect was dose and time dependent. Apoptosis was judged by three criteria, morphology of cells, quantification of subdiploid DNA content by flow cytometry, and detection of DNA fragmentation by gel electrophoresis. Ajoene increased the production of intracellular peroxide in a dose- and time-dependent fashion, which could be partially blocked by preincubation of the human leukemic cells with the antioxidant N-acetylcysteine. Interestingly, N-acetylcysteine-treated cells showed a 50% loss of ajoene-induced apoptosis. Moreover, ajoene was demonstrated to activate nuclear translocation of the transcription factor nuclear factor kappaB, an effect that was abrogated in N-acetylcysteine-loaded cells. These results suggested that ajoene might induce apoptosis in human leukemic cells via stimulation of peroxide production and activation of nuclear factor kappaB. This is a novel aspect in the biological profile of this garlic compound and an important step in elucidating the underlying molecular mechanisms of its antitumor action.

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“…Evidences from laboratory investigations have revealed the anticancer properties of a multitude of medicinal herbs, fruit, and vegetable extracts that are mediated through different mechanisms including altered carcinogen metabolism, induction of DNA repair systems, immune activation, and suppression of cell cycle progression/induction of apoptosis .…”

Section: Introductionmentioning

confidence: 99%

Chemopreventive effect of Mentha piperita on dimethylbenz[a]anthracene and formaldehyde‐induced tongue carcinogenesis in mice (histological and immunohistochemical study)

Kasem

Hegazy

Arafa

et al. 2014

J Oral Pathology Medicine

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Organosulfur Compounds and Cancer

Cited by 19 publications

References 38 publications

Antioxidative effects of diallyl trisulfide on hydrogen peroxide-induced cytotoxicity through regulation of nuclear factor-E2-related factor-mediated thioredoxin reductase 1 expression in C2C12 skeletal muscle myoblast cells

Antioxidative effects of diallyl trisulfide on hydrogen peroxide-induced cytotoxicity through regulation of nuclear factor-E2-related factor-mediated thioredoxin reductase 1 expression in C2C12 skeletal muscle myoblast cells

Ajoene, a Compound of Garlic, Induces Apoptosis in Human Promyeloleukemic Cells, Accompanied by Generation of Reactive Oxygen Species and Activation of Nuclear Factor κB

Chemopreventive effect of Mentha piperita on dimethylbenz[a]anthracene and formaldehyde‐induced tongue carcinogenesis in mice (histological and immunohistochemical study)

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