Diagnostics on acute myocardial infarction: Cardiac troponin biomarkers

Fathil, M. F. M.; Arshad, M. K. Md; Gopinath, Subash C.B.; Hashim, U.; Adzhri, R.; Ayub, R. M.; Ruslinda, A. Rahim; Azman, A. H.; Zaki, Mohd; Tang, Thean‐Hock

doi:10.1016/j.bios.2015.03.037

Cited by 198 publications

(107 citation statements)

References 83 publications

(82 reference statements)

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“…These include troponin C, which binds Ca2 + , troponin I (TnI), which binds to actin and inhibits actin-myosin interactions, and troponin T (TnT), which binds to tropomyosin, thereby attaching the troponin complex to the thin filament. Following myocyte injury, the initial release of cTnT and cTnI is from the cytosolic pool, followed subsequently by release from the structural (myofilamentbound) pool [5].…”

Section: Troponin I (Tni)mentioning

confidence: 99%

Left Ventricular Remodeling after Acute Myocardial Infarction and Biomarkers

Žaliaduonytė-Pekšienė¹,

Portacenko²

2017

J Cardiovasc Dis Diagn

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Considering to pathogenetic mechanisms of MI a few classical biomarkers have been used for diagnosis of MI or acute coronary syndrome. Lately novel markers have been identified to provide diagnostic and prognostic information and outcome of MI or acute coronary syndrome. A few novel biomarkers are overviewed in this article. A few novel biomarkers mentioned in this article showed significant relation to left ventricle remodelling and poor prognosis after myocardial infarction.

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Section: Troponin I (Tni)mentioning

confidence: 99%

Left Ventricular Remodeling after Acute Myocardial Infarction and Biomarkers

Žaliaduonytė-Pekšienė¹,

Portacenko²

2017

J Cardiovasc Dis Diagn

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“…The corresponding damage caused by cardiomyocytes is subject to physical, chemical and biological factors. It has been suggested that cardiomyocytes release cTnI into the blood stream promptly due to the integrity loss of the cardiomyocytes membrane, resulting in the abnormal elevation of the troponin serum [5]. The expression level of cTnI is peaked at 18-24 hours after cardiomyocytes being damaging, just before the disease progresses start [5].…”

Section: Introductionmentioning

confidence: 98%

“…It has been suggested that cardiomyocytes release cTnI into the blood stream promptly due to the integrity loss of the cardiomyocytes membrane, resulting in the abnormal elevation of the troponin serum [5]. The expression level of cTnI is peaked at 18-24 hours after cardiomyocytes being damaging, just before the disease progresses start [5]. The cTnI serum exhibits both high sensitivity and specificity for diagnosing the myocardial injury, suggesting it a potential specific marker for cardiomyocytes damage.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Indicating Value of Cardiac Troponin I, Tumor Necrosis Factor-α, Interleukin-18, Mir-1 and Mir-146b for Viral Myocarditis among Children

Wang

Cui

et al. 2016

Cell Physiol Biochem

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Background/Aims: The primary objective of this study is to evaluate the diagnosis effect of serum protein factors and microRNAs for children suffering from viral myocarditis (VMC). Methods: The expression levels of serum cardiac troponin I (cTnI), interleukin-18 (IL-18) and tumor necrosis factor-α (TNF-α) in both VMC and control groups were examined by using the Elisa Kit. The expression levels of miR-1 and miR-146b were measured through RT-PCR. Subsequently, the Receiver Operating Characteristic (ROC) curves were drawn based on the diagnostic results of VMC. Moreover, the Spearman correlation analysis was carried out to unveil the association between the indicator expression levels and the ultrasonic cardiogram results, including the left ventricular fractional shortening (FS) and left ventricular ejection fraction (EF). Results: It is found that the expression levels between the VMC and control group portrait significant differences with respect to cTnI, IL-18, TNF-α, miR-1 and mIR-146b (P < 0.05). The diagnostic thresholds for cTnI, IL-18, TNF-α were 160.00 ng/L, 2.26 ng/L and 1.14ng/L, respectively. The diagnostic thresholds for miR-1 and miR-146b were 0.75 and 1.27, respectively. Results from the Spearman correlation analysis showed that levels of the miR-1 were negatively correlated with FS and EF, while levels of the cTnI, IL-18, TNF-α and miR-146b were positively correlated with FS and EF. Conclusions: The expression levels of the TNF-α, IL-18 and cTnI and the expression levels of the miR-1 and miR-146b could be used to predict VMC among children and this approach may reinforce the diagnosis of VMC in clinical practices.

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“…The determination of AMI through the discovery of cardiac troponin (cTn) as an indicator has aided doctors in decision making and helped in providing adequate treatment to the patients; thus, giving hope for more accurate and sensitive results [8]. The cardiology consensus, Joint European Society of Cardiology -American College of Cardiology FoundationWorld Heart Federation [6], has named cTnI and cTnT as gold standard markers for the detection of AMI; thus, driving the growth of new devices and technologies to detect cTnI and cTnT with high sensitivity and selectivity, as a high performance system.…”

Section: Introductionmentioning

confidence: 99%