Diagnostic Value of the Estimation of Glucose in Ascitic Fluid

Polak, Monika; Costa, Ariel

doi:10.1159/000197334

Cited by 25 publications

(6 citation statements)

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“…63 Other tests and specific situations where these may be useful Glucose Since glucose diffuses readily across membranes, the concentration in ascitic fluid will reflect the prevailing plasma concentration unless it is being metabolized by bacteria or fluid white blood cells. Decreased ascitic fluid glucose concentration has been reported in TB peritonitis, carcinomatosis and SBP, 64,65 and has been regarded as helpful in differentiating infection and malignant ascites from other causes. However, in early SBP the ascitic fluid glucose was shown to be similar to that in sterile fluid and overall glucose appears to be of low diagnostic sensitivity and specificity, limiting its routine use.…”

Section: Albumin Gradient Introductionmentioning

confidence: 99%

Biochemical analysis of ascitic (peritoneal) fluid: what should we measure?

Tarn

Lapworth

2010

Ann Clin Biochem

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Ascitic fluid samples are frequently sent to the laboratory for analysis. Although the underlying cause of the ascites is often thought to be clinically obvious, it is important to establish a definitive diagnosis. The value of a cell count and bacterial culture of the ascitic fluid is not disputed, but the role of biochemical testing is less clear. The use of ascitic fluid total protein to try to classify ascitic fluids as either an exudate or a transudate has contributed to this. The use of the physiologically based serum ascites albumin gradient to differentiate ascites caused by portal hypertension from other causes provides a better diagnostic approach. We recommend that the serum ascites albumin gradient is performed by laboratories as the first-line test and that interpretative reports are provided. Additional testing should be restricted to specific diagnostic queries and requires close collaboration between the laboratory and the clinician.

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Section: Albumin Gradient Introductionmentioning

confidence: 99%

Biochemical analysis of ascitic (peritoneal) fluid: what should we measure?

Tarn

Lapworth

2010

Ann Clin Biochem

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“…According to the hypothesis in the reports, peritoneal glucose level fluctuates with blood glucose concentration in healthy conditions. Nevertheless, for peritoneal carcinomatosis and peritonitis patients, the tumor cells or microorganisms in their peritoneal cavities uptake glucose in ascites and result in a lower glucose concentration in ascites [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Smartphone-Based Electrochemical Systems for Glucose Monitoring in Biofluids: A Review

Yan

Liu

2022

Sensors

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As a vital biomarker, glucose plays an important role in multiple physiological and pathological processes. Thus, glucose detection has become an important direction in the electrochemical analysis field. In order to realize more convenient, real-time, comfortable and accurate monitoring, smartphone-based portable, wearable and implantable electrochemical glucose monitoring is progressing rapidly. In this review, we firstly introduce technologies integrated in smartphones and the advantages of these technologies in electrochemical glucose detection. Subsequently, this overview illustrates the advances of smartphone-based portable, wearable and implantable electrochemical glucose monitoring systems in diverse biofluids over the last ten years (2012–2022). Specifically, some interesting and innovative technologies are highlighted. In the last section, after discussing the challenges in this field, we offer some future directions, such as application of advanced nanomaterials, novel power sources, simultaneous detection of multiple markers and a closed-loop system.

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“…Early and efficient differentiation between malignant and non-malignant causes of ascites is important for rapid and adequate further diagnostic measures and management of a patient. Unfortunately, the laboratory tests used until now including serum/ascites albumin concentration gradient [I], protein content [2], cell count [3], lactic acid dehydroxygenase [4], glucose concentration [5], and pH [6] are not sufficiently accurate. Furthermore, cytological investiga- tion of ascitic fluid in neoplastic disease reveals malignant cells in only 50-70% of cases [7-91. Measurement of fibronectin in ascites of malignant and non-malignant origin has, however, led to a sensitivity of up to 90% in detecting underlying malignant diseases [9-111. Studies comparing non-malignant ascites of liver cirrhosis and malignant ascites of ovarian cancer have shown a higher extent of catabolism of fibrinogen and fibrin, resulting in a higher level of cross-linked fibrin(ogen) degradation products in malignant ascites [ 1 1,121.…”

Section: Introductionmentioning

confidence: 99%

Plasminogen activators and plasminogen activator inhibitor in malignant and non‐malignant ascitic fluid

Huber

Wojta

Kirchheimer

et al. 1988

Eur J Clin Investigation

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Ascitic fluid from tumour patients (hepatoma, gastric cancer, gallbladder cancer, colorectal cancer, ovarian cancer) and from non-malignant diseases (liver cirrhosis, congestive heart failure) were compared with respect to their content of determinants of the fibrinolytic system, tissue-type plasminogen activator antigen (t-PAag) and activity (t-PAact), urokinase-type plasminogen activator antigen (u-PA) and plasminogen activator inhibitor activity (PAI). Furthermore, SDS-polyacrylamide slab-gel electrophoresis (SDS-PAGE) was performed to evaluate molecular weight distribution of the detectable fibrinolytic parameters. In malignant ascites, PAI activity was three to four times higher, and increased complex formation of PAI with t-PA could be demonstrated, compared with non-malignant ascitic fluid. Tissue-type plasminogen activator antigen and activity showed a similar concentration in ascites of both study groups. Urokinase-type plasminogen activator antigen was detectable neither in ascites of malignant nor in ascites of non-malignant origin. It is concluded that t-PA is the physiological plasminogen activator in ascites and that increased PAI levels followed by increased complex formation between t-PA and PAI might reflect a reaction of the peritoneum.

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Diagnostic Value of the Estimation of Glucose in Ascitic Fluid

Cited by 25 publications

References 0 publications

Biochemical analysis of ascitic (peritoneal) fluid: what should we measure?

Biochemical analysis of ascitic (peritoneal) fluid: what should we measure?

Smartphone-Based Electrochemical Systems for Glucose Monitoring in Biofluids: A Review

Plasminogen activators and plasminogen activator inhibitor in malignant and non‐malignant ascitic fluid

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