Dental caries caused by oral microbiome dysbiosis with the elevation of acidogenic bacteria is the most prevalent non-communicable disease worldwide. Early prevention and timely fluoride treatment are crucial for caries lesion management. Herein, to address the challenges of in situ sensing and topical drug delivery within the oral cavity, a miniaturized, battery-free, and wearable dental patch system was developed for microenvironment monitoring and controlled fluoride treatment. With the integration of near-field communication, the dental patch realizes wireless energy harvesting and data transmission with mobile terminals like smartphones when attached conformally to the tooth surface. The acidic microenvironment caused by bacterial metabolism are electrochemically detected, while fluorides can be delivered locally from the electric-responsive drug delivery electrode for on-demand treatment. As flexible electronics armed to the teeth, this intraoral theranostic wearable system provides an inspiring platform for point-of-care monitoring and treatment of dental caries and oral diseases.
As a vital biomarker, glucose plays an important role in multiple physiological and pathological processes. Thus, glucose detection has become an important direction in the electrochemical analysis field. In order to realize more convenient, real-time, comfortable and accurate monitoring, smartphone-based portable, wearable and implantable electrochemical glucose monitoring is progressing rapidly. In this review, we firstly introduce technologies integrated in smartphones and the advantages of these technologies in electrochemical glucose detection. Subsequently, this overview illustrates the advances of smartphone-based portable, wearable and implantable electrochemical glucose monitoring systems in diverse biofluids over the last ten years (2012–2022). Specifically, some interesting and innovative technologies are highlighted. In the last section, after discussing the challenges in this field, we offer some future directions, such as application of advanced nanomaterials, novel power sources, simultaneous detection of multiple markers and a closed-loop system.
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