Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Critically-Ill, Postoperative Patients With Suspected Sepsis

Li, Lifen; Chen, Juan; Ouyang, Bo; Chen, Minying; Guan, Xiangdong; Zhu, Zhiwen

doi:10.1097/maj.0b013e318253a1a6

Cited by 23 publications

(22 citation statements)

References 33 publications

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“…Although the heterogeneity among studies was significant, we had stable results for sensitivity analysis. Moreover, the pooled diagnostic test results are consistent with the other meta-analysis results (Wacker et al 2013; Wu et al 2012; Li et al 2013a, b). …”

Section: Discussionsupporting

confidence: 89%

“…Finally, 86 studies were included after two updated searches in February 2015 and September 2016 (Fig. 1) (Abidi et al 2008; Ahmadinejad et al 2009; Al-Nawas et al 1996; Anand et al 2015; Balc et al 2003; Barati et al 2010; Battista et al 2016; Bell et al 2003; Beqja-Lika et al 2013; Carpio et al 2015; Castelli et al 2004; Clec’h et al 2006; de Pablo et al 2013; Dorizzi et al 2006; Du et al 2003; Endo et al 2012; Farag et al 2013; Feng et al 2012; Gaini et al 2006; Garnacho-Montero et al 2014; Gerrits et al 2013; Giamarellos-Bourboulis et al 2008; Gibot et al 2004; Godnic et al 2015; Guven et al 2002; Han et al 2016; Harbarth et al 2001; Hoenigl et al 2013; Hou et al 2012, 2016; Hsu et al 2011; Ishikura et al 2014; Ivancevic et al 2008; Jekarl et al 2013, 2014; Jiang et al 2015; Kim and Zhang 2012; Kofoed et al 2007; Latour-Perez et al 2010; Lewis et al 2015; Li et al 2013a; Lin et al 2015; Matera et al 2013; Mat-Nor et al 2016; Mearelli et al 2014; Meynaar et al 2011; Miglietta et al 2015; Miller et al 1999; Muthiah et al 2007, Naeini and Montazerolghaem 2006; Oshita et al 2010; Papadimitriou-Olivgeris et al 2015; Ratzinger et al 2013; Reichsoellner et al 2014; Righi et al 2014; Rivera-Chavez and Minei 2009; Rogina et al 2014; Romualdo et al 2014; Ruiz-Alvarez et al 2009; Sakr et al 2008; Scherpereel et al 2006; Schulte et al 2011; Selberg et al 2000; Seok et al 2012; Shozushima et al 2011; Sierra et al 2004; Su et al 2012, 2013; Sungurtekin et al …”

Section: Resultsmentioning

confidence: 99%

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Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis

et al. 2016

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BackgroundSepsis is one of the most common diseases that seriously threaten human health. Although a large number of markers related to sepsis have been reported in the last two decades, the diagnostic accuracy of these biomarkers remains unclear due to the lack of similar baselines among studies. Therefore, we conducted a large systematic review and meta-analysis to evaluate the diagnostic value of biomarkers from studies that included non-infectious systemic inflammatory response syndrome patients as a control group.MethodsWe searched Medline, Embase and the reference lists of identified studies beginning in April 2014. The last retrieval was updated in September 2016.ResultsUltimately, 86 articles fulfilled the inclusion criteria. Sixty biomarkers and 10,438 subjects entered the final analysis. The areas under the receiver operating characteristic curves for the 7 most common biomarkers, including procalcitonin, C-reactive protein, interleukin 6, soluble triggering receptor expressed on myeloid cells-1, presepsin, lipopolysaccharide binding protein and CD64, were 0.85, 0.77, 0.79, 0.85, 0.88, 0.71 and 0.96, respectively. The remaining 53 biomarkers exhibited obvious variances in diagnostic value and methodological quality.ConclusionsAlthough some biomarkers displayed moderate or above moderate diagnostic value for sepsis, the limitations of the methodological quality and sample size may weaken these findings. Currently, we still lack an ideal biomarker to aid in the diagnosis of sepsis. In the future, biomarkers with better diagnostic value as well as a combined diagnosis using multiple biomarkers are expected to solve the challenge of the diagnosis of sepsis.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-016-3591-5) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis

et al. 2016

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“…sTREM-1 cut-off value of 230 pg/mL yielded sensitivity of 98% and specificity of 91% in differentiating patients with SIRS from those with infection. Su et al [27] performed a study involving 144 patients in ICU (60 patients with SIRS and 84 patients with sepsis complicated by new onset of fever). They found that sepsis group had higher serum sTREM-1, PCT, and CRP levels compared with SIRS group (p<0.05) on first day of ICU admission.…”

Section: Discussionmentioning

confidence: 99%

“…Although many studies on predictive value of PCT in diagnosis of bacteremia exist, there are only a few studies about using sTREM-1for the same purpose [19–21, 27, 34]. Ruiz-Gonzales et al [34] suggested that sTREM-1 is useful biomarker in diagnosis of secondary bacteremia due to community-acquired pneumonia.…”

Section: Discussionmentioning

confidence: 99%

“…Ruiz-Gonzales et al [34] suggested that sTREM-1 is useful biomarker in diagnosis of secondary bacteremia due to community-acquired pneumonia. Su et al [27] recently reported that there were no significant differences in serum sTREM-1 or PCT levels between blood culture-positive and negative groups with ICU-acquired new onset fever. However, we found that initial sTREM-1level and APACHE II score were significantly higher in patients with positive blood culture than negative ones (p=0.02, p=0.06, respectively).…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic value of sTREM-1 and procalcitonin levels in the early diagnosis of sepsis

Aksaray

Alagoz

İnan

et al. 2016

North Clin Istanbul

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OBJECTIVE:Sepsis is still major cause of morbidity and mortality, despite improvements in diagnosis and treatment in modern medicine. Therefore, laboratory examinations that provide correct and rapid results are needed to support the diagnosis. This study was conducted to investigate value of immunological indicators procalcitonin (PCT) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in differential diagnosis of patients with sepsis and systemic inflammatory response syndrome (SIRS), as well as to assess their importance in determining prognosis of patients with sepsis.METHODS:Total of 90 patients, 38 with SIRS and 52 with sepsis, who were between the ages 20 to 92, were included in this prospectively planned study. Blood sample was collected from the patients during hospitalization and again in follow-up visit. Enzyme-linked immunosorbent assay (MyBioSource, Inc., San Diego, CA, USA) was used to measure sTREM-1, and PCT was measured using mini VIDAS B.R.A.H.M.S PCT assay (Biomerieux, S.A., Marcy-l’Étoile, France). In addition, patients were clinically assessed using Acute Physiology and Chronic Health Evaluation (APACHE) II scoring system.RESULTS:On day of intensive care unit admission, sTREM-1 and PCT levels, as well as APACHE II score were significantly higher in sepsis group than SIRS group (p=0.001, p=0.01, p=0.001, respectively). Values of sTREM-1 and APACHE II score were higher in the patients with positive blood cultures than those with negative culture results (p=0.002, p=0.006, respectively). PCT, C-reactive protein, and sTREM-1 levels were significantly higher in nonsurviving group. In differentiation of SIRS from sepsis, sTREM-1 cut-off value ≥133 pg/mL and PCT cut-off value of 1.57 ng/mL yielded sensitivity of 71.1% and 67.33%, and specificity of 73.3% and 65.79%, respectively.CONCLUSION:In patients with suspected sepsis, sTREM-1 and PCT can be used as indicators, in addition to scoring systems such as APACHE II and Sepsis-related Organ Failure Assessment score. However, it would be appropriate to support present findings with studies of larger series.

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Plasma interleukin-6 concentration for the diagnosis of sepsis in critically ill adults

Molano-Franco

Arévalo-Rodríguez

Figuls

et al. 2019

Cochrane Database of Systematic Reviews

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Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Critically-Ill, Postoperative Patients With Suspected Sepsis

Cited by 23 publications

References 33 publications

Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis

Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis

Diagnostic value of sTREM-1 and procalcitonin levels in the early diagnosis of sepsis

Plasma interleukin-6 concentration for the diagnosis of sepsis in critically ill adults

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