Diagnostic value of sTREM-1 and procalcitonin levels in the early diagnosis of sepsis

Aksaray, Sebahat; Alagoz, Pinar; İnan, Asuman; Cevan, Simin; Özgültekin, Asu

doi:10.14744/nci.2016.26023

Cited by 19 publications

(17 citation statements)

References 32 publications

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“…In the remaining 385 abstracts, full manuscripts were recruited for further assessment, and 366 articles were excluded with reasons. A final of 19 studies were included in this meta-analysis [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] (Fig. 1).…”

Section: Study Selectionmentioning

confidence: 99%

“…A total of 2418 patients was finally enrolled in this meta-analysis, with the average sepsis prevalence of 60.3%. Among the 19 studies included, 17 were prospective [14,15,17,[19][20][21][22][23][24][25][26][27][28][29][30][31][32] and two were cross-sectional [16,18]; in five studies traumatic or post-operative patients were enrolled exclusively [16,19,22,28,29]. Pulmonary infection was the leading cause of infection in 14 studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…We conducted the meta-analysis in the sub-group of 7 prospective trials conducted in the ICU, in which the patients with SIRS were consecutively recruited [14,15,20,21,25,26,31]. In this relatively homogenous population of patients, the result revealed that the pooled sensitivity of 0.80 (95% CI 0.68 to 0.89), specificity of 0.76 (95% CI 0.64 to 0.84), PLR of 3.3 (95% CI 2.0 to 5.5), NLR of 0.26 (95% 0.14 to 0.48) and DOR of 13 (95% CI 4 to 38) (Additional file 5: Figure S1).…”

Section: Risk Of Bias and Sub-group Analysismentioning

confidence: 99%

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Diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis: a meta-analysis

et al. 2020

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Background: We aim to synthesize the up-to-date studies to investigate the diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis. Results: A total of 19 studies with 2418 patients were finally enrolled in the meta-analysis. The pooled sensitivity was 0.82 (95% CI 0.73 to 0.89), specificity 0.81 (95% CI 0.75 to 0.86), positive likelihood ratio 4.3 (95% CI 3.02 to 6.12), negative likelihood ratio 0.22 (95% CI 0.24 to 0.35), diagnostic odds ratio 20 (95% CI 9 to 41) and AuROC 0.88 (95% CI 0.85 to 0.91). The meta-regression analysis revealed that the sample size, reference standard description, prevalence of sepsis in the trials and consecution of patient recruitment might be the source of heterogeneity. Conclusions: The serum sTREM-1 had a moderate ability in diagnosis in suspected sepsis based on the current studies. However, more large-scale studies were needed to further evaluate the diagnostic accuracy of sTREM-1.

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Section: Study Selectionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Risk Of Bias and Sub-group Analysismentioning

confidence: 99%

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Diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis: a meta-analysis

et al. 2020

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“…Gibot et al (2007) reported that measurement of serum PCT together with s-TREM-1 concentrations could be useful for detecting nosocomial sepsis. Aksaray et al (2016) also reported that s-TREM-1 and PCT are excellent markers for early diagnosis of sepsis. Although further studies are required to confirm them, our preliminary findings indicate that s-TREM-1 could enable postmortem diagnosis of sepsis with good sensitivity and specificity.…”

Section: Discussionmentioning

confidence: 95%

An immunohistochemical study of the diagnostic value of TREM-1 as marker for fatal sepsis cases

Maiese

Bolino

Mastracchio

et al. 2018

Biotechnic & Histochemistry

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Triggering receptor expressed on myeloid cells-1 (TREM-1) is produced and up-regulated by exposure of myeloid cells to lipopolysaccharides or other components of either bacterial or fungal origin, which causes it to be strongly expressed on phagocytes that accumulate in inflamed areas. Because TREM-1 participates in septic shock and in amplifying the inflammatory response to bacterial and fungal infections, we believe it could be an immunohistochemical marker for postmortem diagnosis of sepsis. We tested the anti-TREM-1 antibody in 28 cases of death by septic shock and divided them into two groups. The diagnosis was made according to the criteria of the Surviving Sepsis Campaign. In all cases, blood cultures were positive. The first group was comprised subjects that presented high ante-mortem serum procalcitonin and the soluble form of TREM-1 (s-TREM-1) values. The second group comprised subjects in which s-TREM-1 was not measured ante-mortem. We used samples of brain, heart, lung, liver and kidney for each case to test the anti-TREM-1 antibody. A semiquantitative evaluation of the immunohistochemical findings was made. In lung samples, we found immunostaining in the cells of the monocyte line in 24 of 28 cases, which suggests that TREM-1 is produced principally by cells of the monocyte line. In liver tissue, we found low TREM-staining in the hepatocyte cytoplasm, duct epithelium, the portalbiliary space and blood vessel. In kidney tissue samples, we found the TREM-1 antibody immunostaining in glomeruli and renal tubules. We also found TREM-1 staining in the lumen of blood vessels. Immunohistochemical staining using the anti-TREM-1 antibody can be useful for postmortem diagnosis of sepsis.

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“…A soluble form of TREM-1 (sTREM-1) is released from activated phagocytes and can be found in serum [15]. The plasma level of sTREM-1 appears to be a reliable parameter in differentiating patients with sepsis from those with SIRS [16,17]. However, application of sTREM-1 for the early diagnosis of LC patients with SIRS has not been done.…”

Section: Introductionmentioning

confidence: 99%

Comparison of serum biomarkers for the early diagnosis of patients with liver cirrhosis and systemic inflammatory response syndrome

Yang

Xie

Zhang

et al. 2019

Preprint

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Background Systemic inflammatory response syndrome (SIRS) can cause serious negative effects among patients with liver cirrhosis (LC). . It is very important to finding methods for early diagnose and intervene early in these patients.This study was to assess the accuracy of early diagnostic value of serum biomarkers in patients with LC and SIRS. Methods A total of 123 LC patients were enrolled, 64 of whom were diagnosed with SIRS and 59 patients without SIRS. Various biomarkers and cytokines were measured in two groups of patients: LC+SIRS and LC−SIRS. Receiver operating characteristic curves (ROCs) were used to assess the ability of tested biomarkers to diagnoseLC with SIRS. Results White blood cell (WBC) count, neutrophil percentage(N%), as well as levels of C-reactive protein (CRP), procalcitonin(PCT), soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α, were significantly higher in the LC+SIRS group than in the LC−SIRS group. But only sTREM-1 had high accuracy of the early diagnosis for LC+SIRS. The WBC count, N% as well as levels of CRP, PCT, IL-6, andTNF-α had moderate diagnostic value, and IL-10 had low diagnostic value.The cutoff value of sTREM-1was 179.23 pg/mL and showed 84.4% sensitivity and 93.2% specificity.The AUC of sTREM-1 was 0.904(95%CI 0.899–0.982) and higher than that of the WBC count as well as levels of CRP, PCT, IL-6, IL-10 and TNF-α. In addition, 24 (37.50%) LC+SIRS cases died during 90-day follow-up. Neutrophil percentage as well as levels of CRP, PCT, sTREM-1, IL-6 and TNF-α were significantly higher those who died than in those who survived. Conclusion The WBC count,N% and levels of CRP, PCT, sTREM-1, IL-6, IL-10 and TNF-α are helpful for the early diagnosis of LC+SIRS.Serum sTREM-1 cut-off levels provide better accuracy than customary levels for cirrhosis with SIRS and appears to be a useful early marker to discriminate between SIRS and no-SIRS.It may also be helpful for implications in the prevention and treatment of cirrhosis and SIRS/sepsis.

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Diagnostic value of sTREM-1 and procalcitonin levels in the early diagnosis of sepsis

Cited by 19 publications

References 32 publications

Diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis: a meta-analysis

Diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis: a meta-analysis

An immunohistochemical study of the diagnostic value of TREM-1 as marker for fatal sepsis cases

Comparison of serum biomarkers for the early diagnosis of patients with liver cirrhosis and systemic inflammatory response syndrome

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