Diagnostic Value of Quantitative Tissue Markers (T2 Mapping and ECV) for Acute Cardiac Rejection Diagnosis: A Preliminary Experience

Vermès, Emmanuelle; Pantaleaon, C.; Pucheux, Julien; Mirza, Arslan; Delhommais, Anne; Sirinelli, A

doi:10.1016/j.healun.2016.01.541

Cited by 2 publications

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“…CMR has been proposed as a noninvasive alternative. Recent studies have shown that a combination of T 2 mapping and ECV have the potential to be used as a surrogate biomarker for rejection . Additionally, ECV values are elevated in the myocardium of patients with multiple rejection episodes and may point to a poorer prognosis.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Cardiac T₁ mapping: Techniques and applications

Aherne

Chow

Carr

2019

Magnetic Resonance Imaging

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A key advantage of cardiac magnetic resonance (CMR) imaging over other cardiac imaging modalities is the ability to perform detailed tissue characterization. CMR techniques continue to evolve, with advanced imaging sequences being developed to provide a reproducible, quantitative method of tissue interrogation. The T 1 mapping technique, a pixel-by-pixel method of quantifying T 1 relaxation time of soft tissues, has been shown to be promising for characterization of diseased myocardium in a wide variety of cardiomyopathies. In this review, we describe the basic principles and common techniques for T 1 mapping and its use for native T 1 , postcontrast T 1 , and extracellular volume mapping. We will review a wide range of clinical applications of the technique that can be used for identification and quantification of myocardial edema, fibrosis, and infiltrative diseases with illustrative clinical examples. In addition, we will explore the current limitations of the technique and describe some areas of ongoing development. Level of Evidence: 5 Technical Efficacy: Stage 2

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Section: Clinical Applicationsmentioning

confidence: 99%

Cardiac T₁ mapping: Techniques and applications

Aherne

Chow

Carr

2019

Magnetic Resonance Imaging

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“…myocardial oedema, 13,14 such as in acute allograft rejection. [15][16][17] This has been extensively studied in adult heart transplant patients, 9,15,18,19 but to date there is limited data on its application in the paediatric population.…”

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confidence: 99%

Quantitative cardiac magnetic resonance T2 imaging offers ability to non-invasively predict acute allograft rejection in children

Sethi

Doshi

et al. 2020

Cardiol Young

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Background:Monitoring for acute allograft rejection improves outcomes after cardiac transplantation. Endomyocardial biopsy is the gold standard test defining rejection, but carries risk and has limitations. Cardiac magnetic resonance T2 mapping may be able to predict rejection in adults, but has not been studied in children. Our aim was to evaluate T2 mapping in identifying paediatric cardiac transplant patients with acute rejection.Methods:Eleven paediatric transplant patients presenting 18 times were prospectively enrolled for non-contrast cardiac magnetic resonance at 1.5 T followed by endomyocardial biopsy. Imaging included volumetry, flow, and T2 mapping. Regions of interest were manually selected on the T2 maps using the middle-third technique in the left ventricular septal and lateral wall in a short-axis and four-chamber slice. Mean and maximum T2 values were compared with Student’s t-tests analysis.Results:Five cases of acute rejection were identified in three patients, including two cases of grade 2R on biopsy and three cases of negative biopsy treated for clinical symptoms attributed to rejection (new arrhythmia, decreased exercise capacity). A monotonic trend between increasing T2 values and higher biopsy grades was observed: grade 0R T2 53.4 ± 3 ms, grade 1R T2 54.5 ms ± 3 ms, grade 2R T2 61.3 ± 1 ms. The five rejection cases had significantly higher mean T2 values compared to cases without rejection (58.3 ± 4 ms versus 53 ± 2 ms, p = 0.001).Conclusions:Cardiac magnetic resonance with quantitative T2 mapping may offer a non-invasive method for screening paediatric cardiac transplant patients for acute allograft rejection. More data are needed to understand the relationship between T2 and rejection in children.

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Diagnostic Value of Quantitative Tissue Markers (T2 Mapping and ECV) for Acute Cardiac Rejection Diagnosis: A Preliminary Experience

Cited by 2 publications

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Cardiac T₁ mapping: Techniques and applications

Cardiac T₁ mapping: Techniques and applications

Quantitative cardiac magnetic resonance T2 imaging offers ability to non-invasively predict acute allograft rejection in children

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Diagnostic Value of Quantitative Tissue Markers (T2 Mapping and ECV) for Acute Cardiac Rejection Diagnosis: A Preliminary Experience

Cited by 2 publications

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Cardiac T1 mapping: Techniques and applications

Cardiac T1 mapping: Techniques and applications

Quantitative cardiac magnetic resonance T2 imaging offers ability to non-invasively predict acute allograft rejection in children

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Cardiac T₁ mapping: Techniques and applications

Cardiac T₁ mapping: Techniques and applications