2020
DOI: 10.1017/s104795112000116x
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Quantitative cardiac magnetic resonance T2 imaging offers ability to non-invasively predict acute allograft rejection in children

Abstract: Background:Monitoring for acute allograft rejection improves outcomes after cardiac transplantation. Endomyocardial biopsy is the gold standard test defining rejection, but carries risk and has limitations. Cardiac magnetic resonance T2 mapping may be able to predict rejection in adults, but has not been studied in children. Our aim was to evaluate T2 mapping in identifying paediatric cardiac transplant patients with acute rejection.Methods:Eleven paediatric transplant patients presenting 18 times were prospec… Show more

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Cited by 16 publications
(24 citation statements)
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“…In recent years, CMR has shown substantial promise for detection of graft dysfunction in adult heart transplant recipients [ 21 , 23 , 24 , 28 , 37 , 49 53 ], however, data are quite limited in PHT [ 37 , 38 , 40 , 43 , 54 , 55 ]. Our study demonstrates the safety and feasibility of comprehensive CMR with regadenoson stress perfusion for graft surveillance in PHT.…”
Section: Discussionmentioning
confidence: 99%
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“…In recent years, CMR has shown substantial promise for detection of graft dysfunction in adult heart transplant recipients [ 21 , 23 , 24 , 28 , 37 , 49 53 ], however, data are quite limited in PHT [ 37 , 38 , 40 , 43 , 54 , 55 ]. Our study demonstrates the safety and feasibility of comprehensive CMR with regadenoson stress perfusion for graft surveillance in PHT.…”
Section: Discussionmentioning
confidence: 99%
“…Many adult studies have shown that elevated native T1, T2 and ECV may be markers of acute rejection and CAV [ 21 , 23 26 , 28 , 49 ]. One recent pediatric study showed that there may be trends in T2 that indicate allograft rejection [ 43 ]. In our cohort, only one subject had acute rejection at the time of CMR and that patient showed significant abnormalities in all three parametric variables (T1 = 1193 ms, ECV = 32.1% and T2 = 60 ms), which corroborates studies in which T2 signal has been indicated as a potential marker of acute rejection [ 23 , 24 , 26 , 43 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Cardiac MRI has shown promise for characterization of edema, fibrosis/scar, and myocardial perfusion reserve, as well as potential application for the detection of microvasculopathic changes in the transplanted heart. Sethi et al prospectively evaluated the role of T2 mapping on cardiac MRI to identify rejection in 18 cardiac MRI‐EMB pairs in 11 pediatric HT recipients 78 . Five cases of rejection were identified in three patients (two cases of grade 2R and three cases of biopsy‐negative rejection).…”
Section: Non‐invasive Methods To Detect Asymptomatic Rejectionmentioning
confidence: 99%