2023
DOI: 10.3390/microorganisms11041066
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Diagnostic Performance of Different Laboratory Methods for the Detection of Extrapulmonary Tuberculosis

Abstract: Accurate and appropriate extrapulmonary tuberculosis (EPTB) diagnosis remains challenging due to its paucibacillary nature, requirement of invasive collection procedures, and lack of sensitive tests. This study investigated the diagnostic performance of different methods for the diagnosis of EPTB. A total of 1340 EPTB specimens were collected from presumptive EPTB patients from four different hospitals between November 2015 and March 2017. The collected specimens were tested with AFB microscopy, culture, Xpert… Show more

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Cited by 4 publications
(1 citation statement)
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“…Hence, microscopy-based detection may lead to false negative cases, causing an increase in transmission due to a lack of timely detection. A recent study compared the sensitivity and specificity of M. tb detection in EPTB employing a variety of currently used clinical diagnostic methods and observed only a 25% sensitivity in the case of AFB microscopy compared to the state-of-the-art methods, such as culture-based detection (72.7%), Xpert MTB/RIF (85.6%), and MTBDRplus assay (79.4%) with a 100% specificity for all the methods . Culture test, the current gold standard, is highly sensitive and specific and can detect as few as 10–100 viable bacilli/mL of the specimen and can detect both PTB, EPTB, and paucibacillary (low bacterial load) cases, which may not be detected by sputum smear microscopy.…”
mentioning
confidence: 99%
“…Hence, microscopy-based detection may lead to false negative cases, causing an increase in transmission due to a lack of timely detection. A recent study compared the sensitivity and specificity of M. tb detection in EPTB employing a variety of currently used clinical diagnostic methods and observed only a 25% sensitivity in the case of AFB microscopy compared to the state-of-the-art methods, such as culture-based detection (72.7%), Xpert MTB/RIF (85.6%), and MTBDRplus assay (79.4%) with a 100% specificity for all the methods . Culture test, the current gold standard, is highly sensitive and specific and can detect as few as 10–100 viable bacilli/mL of the specimen and can detect both PTB, EPTB, and paucibacillary (low bacterial load) cases, which may not be detected by sputum smear microscopy.…”
mentioning
confidence: 99%