Diagnostic Accuracy and Safety of Coaxial System in Oncology Patients Treated in a Specialist Cancer Center With Prospective Validation Within Clinical Trial Data

Khan, Khurum; Gonzalez-Exposito, Reyes; Cunningham, David; Koh, Dow‐Mu; Woolston, Andrew; Barber, Louise J.; Griffiths, Beatrice; Kouvelakis, Kyriakos; Calamai, V.; Bali, Monia; Khan, Nasir; Bryant, Annette; Saffery, Claire; Dearman, Charles; Begum, Ruwaida; S, Rao; Starling, Naureen; Watkins, David; Chau, Ian; Braconi, Chiara; Valeri, Nicola; Gerlinger, Marco; Fotiadis, Nicos

doi:10.3389/fonc.2020.01634

Cited by 3 publications

(2 citation statements)

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“…25 With this technique, the coaxial needle protects the puncture tract while gelfoam pellets prevent bleeding and leakage of tumor fragments. 26 In this study, only 1 rabbit (5%) implanted with VX2 liver tumor using this technique demonstrated the presence of an extrahepatic (abdominal wall) nodule. In this study, we chose to implant minced tumor fragments rather than single 3-4 mm 3 tumor fragments.…”

Section: Discussionmentioning

confidence: 62%

Ultrasound-guided percutaneous implantation of rabbit VX2 carcinoma, using a coaxial technique and gelfoam pellet injection combination to establish a rabbit liver tumor model

Cheng¹,

Zhang²,

Wang³

et al. 2022

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 62%

Ultrasound-guided percutaneous implantation of rabbit VX2 carcinoma, using a coaxial technique and gelfoam pellet injection combination to establish a rabbit liver tumor model

Cheng¹,

Zhang²,

Wang³

et al. 2022

Diagn Interv Radiol

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“…Various approaches have been presented to reduce the risk of bleeding such as occluding the biopsy tract with various materials, as the needle is withdrawn (14)(15)(16)(17). However, potential concerns remain regarding immunologic interactions with tissue-based agents and the technical complexity required to introduce the agent into the tract (18).…”

Section: Introductionmentioning

confidence: 99%

A Novel Biopsy Method Based on Bipolar Radiofrequency Biopsy Needles

2022

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Modern oncology increasingly relies on pathological, molecular, and genomic assessments of biopsied tumor tissue. However, the concern for bleeding complication and malignant seeding severely hinders the application of the biopsy tumor. Here, we developed a 16 G biopsy needle to contain two electrodes insulated from each other and connect to an radiofrequency generator. For evaluating hemostatic efficacy, 50 rabbits were randomly divided into two groups: warfarinization and non-warfarinization group. Two liver biopsies and two splenic biopsies per animal were performed using a 16 G biopsy needle. Each group was further equally divided into five groups according to different hemostatic measures, including non-intervention, embolization using an absorbable gelatin sponge, and ablation by RF with three different needle temperatures (50°C, 70°C, and 90°C). Than, we used VX2 rabbit models (n = 25) and applied the five analogous biopsies to the tumor. The flush fluid from the biopsy needle underwent cytomorphological analysis. Our results that the groups using ablation by RF showed significantly less blood loss than the control group for liver and spleen in both groups (P < 0.001). After RF ablation, thermal coagulation of the tissue surrounding the needle tract was observed on both the macroscopic and histological level. Cytological smears showed that tumor cells were degenerated after RF at 70°C and 90°C. Our findings showed that bipolar RF biopsy needle is a promising tool for reducing hemorrhage after biopsy and avoiding implanting tumor cells in the tract.

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Next-Generation Sequencing and Image-Guided Tissue Sampling: A Primer for Interventional Radiologists

Yeung¹,

Fotiadis²,

Diamantopoulos³

et al. 2023

Journal of Vascular and Interventional Radiology

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Diagnostic Accuracy and Safety of Coaxial System in Oncology Patients Treated in a Specialist Cancer Center With Prospective Validation Within Clinical Trial Data

Abstract: Background: Image-guided tissue biopsies are critically important in the diagnosis and management of cancer patients. High-yield samples are also vital for biomarker and resistance mechanism discovery through molecular/genomic analyses.

Cited by 3 publications

References 36 publications

Ultrasound-guided percutaneous implantation of rabbit VX2 carcinoma, using a coaxial technique and gelfoam pellet injection combination to establish a rabbit liver tumor model

Ultrasound-guided percutaneous implantation of rabbit VX2 carcinoma, using a coaxial technique and gelfoam pellet injection combination to establish a rabbit liver tumor model

A Novel Biopsy Method Based on Bipolar Radiofrequency Biopsy Needles

Next-Generation Sequencing and Image-Guided Tissue Sampling: A Primer for Interventional Radiologists

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