Diagnosis of Early Cancer of the Colon and Rectum

Watanabe, Hikaru; Numazawa, Makoto; Shoji, Kenichi; Hiwatashi, Nobuo; Gotō, Yoshio

doi:10.1620/tjem.129.183

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…For esophageal and gastric lesions, the sensitivity of biopsy has been reported between 72% and 92%. The sensitivity of brush cytology has generally ranged between 79% and 93% [5][6][7][9][10][11][12][13]. The majority of these reports concludes that the combination of cytology and histology clearly increases the sensitivity to as high as 97%-99% [6,9,12].…”

Section: Discussionmentioning

confidence: 99%

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Accuracy of biopsy and cytology for the preoperative diagnosis of colorectal adenocarcinoma

et al. 1999

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Section: Discussionmentioning

confidence: 99%

“…No false positives were found. Watanabe et al [10] reported a sensitivity of 86% for cytology and 76% for biopsy for the diagnosis of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of biopsy and cytology for the preoperative diagnosis of colorectal adenocarcinoma

et al. 1999

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“…We have previously reported that most early colorectal cancers are cancercontaining adenomas which present adenoma at non-cancerous part, and that the age distributions are nearly identical for colorectal cancer and adenoma cases (Watanabe et al 1976(Watanabe et al , 1979. These findings suggest that colorectal cancer and adenoma are closely related, probably induced by the same environmental factors.…”

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confidence: 72%

HLA antigens in colorectal cancers and adenomas.

Hiwatashi¹,

Kikuchi²,

Masamune³

et al. 1980

Tohoku J. Exp. Med.

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and GOTO, Y. HLA Antigens in Colorectal Cancers and Adenomas. Tohoku J. exp. Med., 1980, 131 (3), 257-260-An investigation was made of the differences between colorectal cancer and adenoma using HLA markers.Subjects included 60 cases of colorectal cancer, 43 of colorectal adenoma and 120 healthy Japanese controls.In comparison with the controls, Bw40 was increased (p<0.02) and B5 was decreased (p<0.005) in the colorectal adenoma cases, whereas in the colorectal cancer cases, Bw35 was increased (p<0.005).B5 was significantly less frequent in the adenoma cases than in the cancer cases (p<0.05).It is suggested that the susceptibility of Bw35 to the causal factors of colorectal cancer is under genetic control.HLA antigens; colorectal cancer; colorectal adenomaIt is thought that most colorectal cancers originate as colorectal adenomas. We have previously reported that most early colorectal cancers are cancercontaining adenomas which present adenoma at non-cancerous part, and that the age distributions are nearly identical for colorectal cancer and adenoma cases (Watanabe et al. 1976(Watanabe et al. , 1979. These findings suggest that colorectal cancer and adenoma are closely related, probably induced by the same environmental factors. Nevertheless, studies of the long-term course of adenoma show that most adenomas do not develop into cancers, suggesting that there may be differences in the genetic factors between adenomas which ultimately become malignant and those which do not. Here we report the results of an investigation of the HLA antigen profiles of these lesions. SUBJECTS AND METHODSSubjects included 60 cases of cancer (35 of the colon and 25 of the rectum), 43 adenoma cases (13 of the colon and 30 of the rectum) and 120 normal Japanese as controls.HLA typing was made by means of the microdroplet lymphocyte cytotoxicity test (Mittal et al. 1968). Anti-sera were obtained from Behring Institute, Bosei Co. and Dr.

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“…9 The diagnostic yield of colon brush cytology in histologically confirmed malignant neoplasms varies widely. [12][13][14] It ranges from 40% in a study by Deluca 4 to 92% in another report. 2 Other reports suggest the combined use of cytology and biopsy to increase the diagnostic yield.…”

Section: Discussionmentioning

confidence: 99%