Accuracy of biopsy and cytology for the preoperative diagnosis of colorectal adenocarcinoma

Petrelli, Nicholas J.; Létourneau, Richard; Weber, Thomas K.; Nava, Maria Enriqueta R.; Rodrı́guez-Bigas, Miguel A.

doi:10.1002/(sici)1096-9098(199905)71:1<46::aid-jso9>3.0.co;2-t

Cited by 32 publications

(17 citation statements)

References 7 publications

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“…28 In summary, our results using a limited data base are encouraging, and they are expected to improve dramatically with a larger data base and suitable changes in the computational methods.…”

Section: Discussionmentioning

confidence: 57%

Diagnostic potential of Fourier-transform infrared microspectroscopy and advanced computational methods in colon cancer patients

et al. 2002

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Colon cancer is the third leading class of cancer causing increased mortality in developed countries. A polyp is one type of lesion observed in a majority of colon cancer patients. Here, we report a microscopic Fourier transform infrared (FTIR) study of normal, adenomatous polyp and malignant cells from biopsies of 24 patients. The goal of our study was to differentiate an adenomatous polyp from a malignant cell using FTIR microspectroscopy and artificial neural network (ANN) analysis. FTIR spectra and biological markers such as phosphate, RNA/DNA derived from spectra, were useful in identifying normal cells from abnormal ones that consisted of adenomatous polyp and malignant cells. However, the biological markers failed to differentiate between adenomatous polyp and malignant cases. By employing a combination of wavelet features and an ANN based classifier, we were able to classify the different cells as normal, adenomatous polyp and cancerous in a given tissue sample. The percentage of success of classification was 89%, 81%, and 83% for normal, adenomatous polyp, and malignant cells, respectively. A comparison of the method proposed with the pathological method is also discussed.

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Section: Discussionmentioning

confidence: 57%

Diagnostic potential of Fourier-transform infrared microspectroscopy and advanced computational methods in colon cancer patients

et al. 2002

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“…Many researchers discuss issues that could influence the diagnostic accuracy of this applied technique [3,17,18]. In [19].…”

Section: Discussionmentioning

confidence: 99%

The role of liquid-based cytology in the investigation of colorectal lesions: a cytohistopathological correlation and evaluation of diagnostic accuracy

Kontzoglou

Moulakakis

Alexiou

et al. 2007

Langenbecks Arch Surg

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“…2 Other studies have tried introducing brush cytology as well as biopsy to improve the accuracy of the preoperative diagnosis. 3,4 Our results suggest that the overall grading of pre-operative biopsies in colorectal cancer is accurate in less than 50% of cases.…”

Section: Discussionmentioning

confidence: 76%

Reliability of pre-operative biopsies in the histological grading of colorectal adenocarcinomas

Burton

Eddy²,

Li³

et al. 2003

Annals of the Royal College of Surgeons of England

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Background: Management of colorectal cancer depends on many patient and tumour variables. Decisions are sometimes based on the histological grade of tumour as assessed by initial biopsy. This retrospective study looked at the reliability of grading colorectal cancer from pre-operative biopsies. Methods: 118 patients with a diagnosis of colorectal cancer, who had adequate pre-operative biopsies, were included in the study. A single consultant histopathologist re-examined all the preoperative biopsy slides, but was blinded to the final grading of the resection specimen. Results: Of the 118 resection specimens, 41 were graded well-differentiated, 52 moderately differentiated and 25 poorly differentiated. When compared with postoperative grading, 37 (31%) initial biopsies were undergraded, 49 (43%) were correctly graded and 32 (26%) were overgraded. Conclusions: These results suggest that the histological grading of pre-operative specimens is inaccurate and should be used with caution to determine treatment. The difficulty with grading pre-operative biopsies in colorectal cancer may be owing to a lack of specific criteria such as is used in, for example, breast cancer.

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Accuracy of biopsy and cytology for the preoperative diagnosis of colorectal adenocarcinoma

Cited by 32 publications

References 7 publications

Diagnostic potential of Fourier-transform infrared microspectroscopy and advanced computational methods in colon cancer patients

Diagnostic potential of Fourier-transform infrared microspectroscopy and advanced computational methods in colon cancer patients

The role of liquid-based cytology in the investigation of colorectal lesions: a cytohistopathological correlation and evaluation of diagnostic accuracy

Reliability of pre-operative biopsies in the histological grading of colorectal adenocarcinomas

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