The role of liquid-based cytology in the investigation of colorectal lesions: a cytohistopathological correlation and evaluation of diagnostic accuracy

Kontzoglou, Konstantinos; Moulakakis, Konstantinos G.; Alexiou, D; Safioleas, Michael; Nikiteas, Nikolaos; Giahnaki, A. E.; Kyroudes, Aspasia; Kostakis, Alkiviadis; Karakitsos, Petros

doi:10.1007/s00423-006-0120-y

Cited by 12 publications

(11 citation statements)

References 17 publications

(21 reference statements)

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“…The sensitivity of brush cytology (87.9%) and of biopsy (78.3%) obtained in our study are in compliance with the published results, especially with papers that report somewhat higher sensitivity of cytology 8,9,13,14 . We found out higher agreement between cytology and biopsy (86.1%), and also higher percentage of positive cytology alone (16.0%) from positive biopsy alone (7.5%) as compared to the results of Petrelli et al 11 (68.5%, 9.6%, 12.3%, respectively).…”

Section: Discussionsupporting

confidence: 92%

“…For brush cytology the sensitivity ranges from 78.1% to 95.7% and for biopsy from 74% to 96% 8, 9, 11−13 . The highest sensitivity (95.7%) of brush cytology of colorectal region have been shown by Kontzoglou et al 8 who evaluated the role of Thin-Prep ® liquid-based cytology in the investigation of colorectal lesions, and the largest group of patients (918) have been processed by Brouwer et al 13 who have found out the sensitivity of brush cytology to be 88.2% and of biopsy 86.9%.…”

Section: Discussionmentioning

confidence: 99%

“…For the last 15 years, we have found only four papers on evaluation of cytological diagnostics of the lower gastrointestinal (GI) tract by brush cytology 8,12,13,18 .…”

Section: Introductionmentioning

confidence: 99%

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The value of brush cytology and biopsy for the diagnosis of colorectal cancer

et al. 2017

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Background/Aim. Although it is well-known the high sensitivity of brush cytology for the diagnosis of colorectal adenocarcinoma, this kind of diagnostics is not routinely used, and for the past years it has even been declining. The purpose of this study was to evaluate the value of brush cytology for the diagnosis of colorectal carcinoma, by comparison the results of brush cytology and biopsy, and then the results of both diagnostic methods with the final patohistological diagnosis of colorectal resection. Methods. This retrospective study included 173 patients with brush cytology of colorectal region during colonoscopy. In 166 patients concomitant biopsy specimens were obtained, and in 116 of them resection of the intestine as well. A total of the 106 patients underwent to all three diagnostic procedures. Results. Out of 166 patients who went through both brush cytology and biopsy, the congruent diagnosis was made in 129 (77.7%) patients: in 109 (65.7%) adenocarcinoma was diagnosed, which was confirmed after the resection of the intestine in 75 of the patients, and in 14 (8.4%) benign lesion, so there was no need for resection of the intestine. In 6 (3.6%) of the patients, both cytology and biopsy were negative, but the resected specimen was malignant. In 10 of the patients with malignant cytology in whom biopsy was not done, resection of the intestine confirmed malignancy. The sensitivity of detecting malignancy by brush cytology and biopsy were 87.9% and 78.3%, respectively (but this difference was not statistically significant, p = 0.083). Both methods had specificity and positive predictive values 100%. Negative predictive values for cytology and biopsy were 50% and 37.8%, respectively. The accuracy of cytology and biopsy was 89.2% and 80.8%, respectively. The combination of the results of brush cytology and biopsy increased the sensitivity of preoperative diagnostics to 94.8% which was significantly higher than sensitivity of biopsy (p < 0.001), but not than sensitivity of cytology (p = 0.102). Conclusion. Brush cytology could be a routine method, along with biopsy, in the diagnosis of colorectal malignancy. Both methods have comparable both sensitivity and accuracy, and its combination increases sensitivity of preoperative diagnostics of colorectal adenocarcinoma, which gives opportunity to better estimation of further diagnostic and therapeutic approach.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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The value of brush cytology and biopsy for the diagnosis of colorectal cancer

et al. 2017

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“…In lower GIT, anorectal region was the predominant site with 43.33% cases. Similar findings were seen in studies conducted by Sayeed et al and Kontzoglou et al 9,10 Adenocarcinoma was the most common malignancy (97.3%) in lower GIT as seen in other studies. Left side colon was predominant site of lower GIT malignancy with 59.46% cases of malignant lesions.…”

Section: Discussionsupporting

confidence: 90%

Cyto-histological correlation in diagnosis of gastrointestinal lesions- a prospective study in a tertiary care institute

Aggarwal¹,

Mardi²,

Sood³

et al. 2020

Int J Res Med Sci

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Background: Gastrointestinal tract is involved by a large number of inflammatory, infectious and neoplastic diseases. There is a worldwide rising incidence of GIT lesions especially neoplasms.Methods: This study was planned to correlate endoscopic and colonoscopic brush cytology with histopathology of gastrointestinal lesions and to determine the spectrum of gastrointestinal lesions in patients subjected to endoscopic brushings and biopsy.Results: Sensitivity of upper GI brush cytology was 95.15% and specificity 90.41%. Sensitivity of colonoscopic brush cytology was 100% and specificity 86.79%. The accuracy of brush cytology came out to be 92.45% in upper GIT and 92.22% in lower GIT.Conclusions: Brush cytology is a non-invasive and cost-effective method to retrieve epithelial cells from a much larger surface area of the mucosa, thus allowing thorough sampling and increasing the diagnostic yield.

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“…Η κυτταρολογία υγρής φάσης δεν αποτελεί μέθοδο διαδεδομένη, εν μέρει λόγω της ευρείας διάδοσης της βιοψίας, αλλά και επιπλέον λόγω της έλλειψης επιστημονικών στοιχείων και δεδομένων περί της αξιοπιστίας, της ευκολίας και του κόστους της μεθόδου. Ελάχιστες παρόμοιες μελέτες έχουν διεξαχθεί και αφορούν κυρίως στη διάγνωση για αδενοκαρκινώματα του παχέος εντέρου μέσω της κυτταρολογίας υγρής φάσης, με αποτελέσματα αμφιλεγόμενα (67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83) .…”

Section: ειδικο μεροςunclassified

Ο Ρόλος Της Κυτταρολογίας Υγρής Φάσης Στη Διερεύνηση Των Αλλοιώσεων Του Παχέος Εντέρου

Τρανουδάκης¹

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The role of liquid-based cytology in the investigation of colorectal lesions: a cytohistopathological correlation and evaluation of diagnostic accuracy

Cited by 12 publications

References 17 publications

The value of brush cytology and biopsy for the diagnosis of colorectal cancer

The value of brush cytology and biopsy for the diagnosis of colorectal cancer

Cyto-histological correlation in diagnosis of gastrointestinal lesions- a prospective study in a tertiary care institute

Ο Ρόλος Της Κυτταρολογίας Υγρής Φάσης Στη Διερεύνηση Των Αλλοιώσεων Του Παχέος Εντέρου

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