HLA antigens in colorectal cancers and adenomas.

Abstract

and GOTO, Y. HLA Antigens in Colorectal Cancers and Adenomas. Tohoku J. exp. Med., 1980, 131 (3), 257-260-An investigation was made of the differences between colorectal cancer and adenoma using HLA markers.Subjects included 60 cases of colorectal cancer, 43 of colorectal adenoma and 120 healthy Japanese controls.In comparison with the controls, Bw40 was increased (p<0.02) and B5 was decreased (p<0.005) in the colorectal adenoma cases, whereas in the colorectal cancer cases, Bw35 was increased (p<0.005).B5 was significantly less frequent in the adenoma cases than in the cancer cases (p<0.05).It is suggested that the susceptibility of Bw35 to the causal factors of colorectal cancer is under genetic control.HLA antigens; colorectal cancer; colorectal adenomaIt is thought that most colorectal cancers originate as colorectal adenomas. We have previously reported that most early colorectal cancers are cancercontaining adenomas which present adenoma at non-cancerous part, and that the age distributions are nearly identical for colorectal cancer and adenoma cases (Watanabe et al. 1976(Watanabe et al. , 1979. These findings suggest that colorectal cancer and adenoma are closely related, probably induced by the same environmental factors. Nevertheless, studies of the long-term course of adenoma show that most adenomas do not develop into cancers, suggesting that there may be differences in the genetic factors between adenomas which ultimately become malignant and those which do not. Here we report the results of an investigation of the HLA antigen profiles of these lesions. SUBJECTS AND METHODSSubjects included 60 cases of cancer (35 of the colon and 25 of the rectum), 43 adenoma cases (13 of the colon and 30 of the rectum) and 120 normal Japanese as controls.HLA typing was made by means of the microdroplet lymphocyte cytotoxicity test (Mittal et al. 1968). Anti-sera were obtained from Behring Institute, Bosei Co. and Dr.

Exclusion of a tight linkage between familial polyposis coli and HLA

“…Two previous studies in large CFS families with predominantly colon cancer reported an excess of affected members sharing the same HLA haplotype (Lynch et al 1975, Katano et al 1980. In a recent intra-population study, Hiwatashi et al (1980) found associations between some HLA antigens and, respectively, colorectal adenoma cases (Bw40 increased, B5 decreased) and colorectal cancer cases (Bw35 increased) when compared to healthy Japanese controls. They also reported previous findings of other HLA-A or B antigens associated with colorectal cancer in Caucasians.…”