Diagnosis, management and treatment of hepatitis delta virus infection: Turkey 2017 Clinical Practice Guidelines

Yurdaydın, Cihan; Tabak, Fehmı; Kaymakoğlu, Sabahattin; Akarsu, Mesut; Akıncı, Esra G; Akkız, Hikmet; Alkım, Canan; Çekın, Ayhan Hilmi; Çuvalci, Nefise Öztoprak; Demır, Kadir; Değertekın, Bülent; Dökmetaş, İlyas; Ersöz, Galip; Hızel, Kenan; Kandemir, Fatma Ö; Önlen, Yüsüf; Sonsuz, Abdullah; Şenateş, Ebubekir; Tosun, Selma; Tözün, Nurdan; İdilman, Ramazan

doi:10.5152/tjg.2017.20

Cited by 7 publications

(3 citation statements)

References 43 publications

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“…The first approach in the diagnosis of HDV infection is to investigate the antibodies against HDV-Ag in HBsAg-positive individuals. Anti-HDV antibody can be detected in immunocompetent patients with HDV infection (10). While anti-HDV immunoglobulin G (IgG) antibodies are detected in individuals with HDV infection even after clearance of the virus, anti-HDV IgM antibodies can be detected as a serological marker of HDV replication in the majority of patients with acute infection (12).…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of acute HDV co-infection is based on the detection of HDV-Ag, HDV-RNA and anti-HDV antibodies, together with markers of HBV infection. HBV-DNA, an indicator of HBV replication, could be suppressed during acute HDV infection and could not be detected (10,11). Therefore, all HBsAg positive patients should be analyzed anti-HDV antibody testing and especially should be recommended in case of acute hepatic exacerbation (10).…”

Section: Introductionmentioning

confidence: 99%

“…HBV-DNA, an indicator of HBV replication, could be suppressed during acute HDV infection and could not be detected (10,11). Therefore, all HBsAg positive patients should be analyzed anti-HDV antibody testing and especially should be recommended in case of acute hepatic exacerbation (10). The diagnosis of chronic HDV infection is determined by the absence of immunoglobulin M (IgM) antibody against hepatitis B core antigen and the presence of HBV and HDV infection markers.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Signal/Cut-off Ratio by Anti-hepatitis Delta Virus Enzyme Immunoassay Method in the Diagnosis of Hepatitis Delta Virus Infection

Bakır¹,

Karabulut²,

Alaçam³

et al. 2019

vhd

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Amaç: Hepatit delta virüsü (HDV), Deltavirus genusunda, zarflı, negatif polariteli, tek iplikli bir RNA virüsüdür. Bu çalışmada, anti-HDV pozitif olan hastalarda HDV enfeksiyonu tanısında anti-HDV sinyal/ cutoff (S/CO) oranının değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Ağustos 2014-Aralık 2018 tarihleri arasında hepatit B yüzey antijeni (HBsAg) ve anti-HDV pozitif saptanan ve HDV-RNA testi çalışılmış toplam 156 hasta çalışmaya dahil edildi. Anti-HDV antikoru ve HBsAg testleri serum örneklerinde mikro-ELISA yöntemi ile, HDV-RNA testi ise plazma örneklerinde real-time polimeraz zincir reaksiyonu yöntemi ile çalışıldı. Bulgular: Anti-HDV pozitif hastaların %42,9'unda (67/156) HDV-RNA saptandı. HDV-RNA pozitif grubun anti-HDV S/CO ortalaması (8,99±3,53), HDV-RNA negatif gruba (5,99±3,73) göre anlamlı olarak yüksek saptandı (p<0,001). Alıcı işletim karakteristiği (ROC) analizi ile S/CO değeri 6,13 belirlendiğinde; duyarlılık, özgüllük, pozitif ve negatif prediktif değerler sırasıyla %79,

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Signal/Cut-off Ratio by Anti-hepatitis Delta Virus Enzyme Immunoassay Method in the Diagnosis of Hepatitis Delta Virus Infection

Bakır¹,

Karabulut²,

Alaçam³

et al. 2019

vhd

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Chronic Hepatitis B

Bergasa

2021

Clinical Cases in Hepatology

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The impact of economic and social factors on the prevalence of hepatitis B in Turkey

et al. 2018

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BackgroundViral Hepatitis is one of the major global health problems, affecting millions of people every year. Limited information is available on the impact of social and economic factors on the prevalence of Hepatitis B virus (HBV) in Turkey. This study, contrary to other studies in the literature, was undertaken with the aim of examining the Majority of the excluded data come from the volunteers.MethodsThere are medical and the social-economic factors affecting the prevalence of HBV. This research, while taking medical factors as control variables, clarify the social and economic factors affecting the prevalence of HBV by utilising clinical data with the use of the Binary Probit Model (BPM). The BPM estimation is a powerful tool to determine not only the factors but explain also the exact impacts of each factor.ResultsThe estimations of the BPM shows that economic and social variables such as age, gender, migration, education, awareness, social welfare, occupation are very important factors for determining HBV prevalence. Compared to the youngest population, the 46 to 66+ age group has a higher prevalence of HBV. The male respondents were 5% more likely to develop HBV compared to females. When region-specific differences are taken into account, migrating from the poorest parts of the country such as the eastern and south-eastern regions of Turkey are approximately 16% more likely to be infected. The welfare indicators such as a higher number of rooms in the respondent’s house or flat decreases the probability of having HBV and, relatively higher income groups are less likely to develop HBV compared to labourers. The Self-employed/Business owner/Public sector worker category are approximately 10% less likely to develop HBV. When people are aware of the methods of prevention of HBV, they are 6% less likely to be infected. Previous HBV infection history increases the probability of having HBV again B by 17%.ConclusionsThese findings strongly suggest that the impact of social and economic factors on the prevalence of HBV is vital. Any improvements in these factors are likely to reduce prevalence of HBV.

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Diagnosis, management and treatment of hepatitis delta virus infection: Turkey 2017 Clinical Practice Guidelines

Cited by 7 publications

References 43 publications

Evaluation of Signal/Cut-off Ratio by Anti-hepatitis Delta Virus Enzyme Immunoassay Method in the Diagnosis of Hepatitis Delta Virus Infection

Evaluation of Signal/Cut-off Ratio by Anti-hepatitis Delta Virus Enzyme Immunoassay Method in the Diagnosis of Hepatitis Delta Virus Infection

Chronic Hepatitis B

The impact of economic and social factors on the prevalence of hepatitis B in Turkey

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