Diagnosis and management of rheumatoid arthritis

Tracey, Gerald

doi:10.1002/psb.1580

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2022

2023

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“…The "classic" patient profile for RA is a woman between 50-75 years with a history of tobacco use who presents with pain and swelling or stiffness in at least seven symmetrical joints of the hands or feet [ 5 , 6 ]. The joint pain worsens in the morning, lasting more than one hour and improving with movement [ 5 , 7 ]. Associated constitutional symptoms include fatigue, malaise, and weight loss [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

An Atypical Presentation of Seronegative Rheumatoid Arthritis

Ramnauth¹,

Rooney²

2023

Cureus

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The American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 1987 classification for rheumatoid arthritis (RA) focuses on four main clinical findings without emphasizing biomarker serology. On the other hand, the updated ACR/EULAR 2010 classification relies more on acutephase reactants and biomarker serology. While a positive rheumatoid factor (RF) and positive anticitrullinated protein antibody (ACPA) are specific for RA, at least 15%-25% of patients are seronegative. Given that the ACR/EULAR 2010 classification is more likely to miss these seronegative patients, clinical judgment is important while assessing patients to avoid delays in diagnosis and onset of treatment.

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Section: Introductionmentioning

confidence: 99%