Diabetic ulcer regeneration: stem cells, biomaterials, growth factors

Zarei, Farshad; Negahdari, Babak; Eatemadi, Ali

doi:10.1080/21691401.2017.1304407

Cited by 37 publications

(33 citation statements)

References 78 publications

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“…These proteins can also be sequestered by ECM for presentation of cell surface receptors. Growth factors can act via autocrine, paracrine, and endocrine mechanisms [32,[84][85][86]. When GFs reach a suitable concentration, the reparation process begins.…”

Section: Growth Factorsmentioning

confidence: 99%

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Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

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Section: Growth Factorsmentioning

confidence: 99%

“…The FGFs are arranged into seven subfamilies [100]. Basic fibroblast growth factor-2 (FGF-2) is produced by fibroblasts and endothelial cells [86]. It primarily simulates cell proliferation and differentiation [73,91].…”

Section: Fibroblast Growth Factor-2 (Fgf-2)mentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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“…Additionally, stem cells from the apical papilla (SCAP) treated with bFGF can be reprogrammed to a more developmentally potent stage by up‐regulating Stro1, Oct4, and Sox2, revealing that bFGF might contribute to establishing a suitable microenvironment for maintaining cells in an undifferentiated stage. However, growth factors can influence genetic events in cells, potentially leading to malignancy, and are expensive to produce, highlighting the need for safe alternatives …”

Section: Discussionmentioning

confidence: 99%

“…However, growth factors can influence genetic events in cells, potentially leading to malignancy, 33 and are expensive to produce, highlighting the need for safe alternatives. 34 Bredigite, a silicate-based bioceramic, has received significant attention because it can release bioactive ions and trigger specific cellular responses during tissue engineering. 35 Bredigite possesses an advantage due to its relatively stable chemical and physical properties and controllable ion release 13 compared with growth factors.…”

Section: Discussionmentioning

confidence: 99%

The extracts of bredigite bioceramics enhanced the pluripotency of human dental pulp cells

Liu

Yang

et al. 2017

J Biomedical Materials Res

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Biomaterials have a profound effect on tissue engineering and regenerative medicine, but few studies have reported the role of extracts from bioceramics in the regulation of stem cell pluripotency. The present study investigated the effects of bioceramics extracts, including silicate bredigite (Ca7MgSi4O16) and conventional β‐tricalcium phosphate (β‐TCP), on the pluripotency and the multilineage differentiation potential of human dental pulp cells (hDPCs). Basic fibroblast growth factor (bFGF), which is a known regulator of hDPCs pluripotency, was used as a reference. Bredigite extracts significantly promoted cell growth, proliferation, TERT expression and maintained hDPCs in a presenescent state. The extracts of bredigite significantly up‐regulated the expression of pluripotency‐related genes such as Stro1, Oct4 and Sox2, and further promoted the multilineage differentiation of hDPCs after odontogenic/adipogenic induction. The stimulation of bredigite extracts on hDPCs pluripotency was comparable to that of bFGF, whereas β‐TCP extracts lacked these properties. Our results suggested for the first time that bredigite extracts enhance the pluripotency of dental‐derived stem cells, paving the way for extended applications in regenerative medicine. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3465–3474, 2017.

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“…The PVP layer was loaded in situ with an antibiotic (ciprofloxacin, CFX) and a release of 30% to 60% of CFX was observed in all patches within the first 6 h, followed by a constant (linear) release during the first 48 h. This represented a controlled and one-step treatment of DFUs [138]. Another study offered a list of several polymers used to transport active principles to the wound region; these polymers had a certain degree of success and positive results against DFUs [139]. Gelatin microspheres carrying FGFb in a mice model demonstrated a significant decrease in the rate of infection and accelerated fibroblast proliferation [140].…”

Section: Nanomedicinementioning

confidence: 99%

Diabetic Foot Ulcers: Current Advances in Antimicrobial Therapies and Emerging Treatments

et al. 2019

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Diabetic foot ulcers (DFUs) are very important diabetes-related lesions that can lead to serious physical consequences like amputations of limbs and equally severe social, psychological, and economic outcomes. It is reported that up to 25% of patients with diabetes develop a DFU in their lifetime, and more than half of them become infected. Therefore, it is essential to manage infection and ulcer recovery to prevent negatives outcomes. The available information plays a significant role in keeping both physicians and patients aware of the emerging therapies against DFUs. The purpose of this review is to compile the currently available approaches in the managing and treatment of DFUs, including molecular and regenerative medicine, antimicrobial and energy-based therapies, and the use of plant extracts, antimicrobial peptides, growth factors, ozone, devices, and nano-medicine, to offer an overview of the assessment of this condition.2 of 32 history [2]. DFUs are one of the most severe complications of diabetes, and more than half of those ulcers become infected. Every single one of these infected lesions has the potential to get worse and compromise the integrity of the lower limbs. To avoid amputations and improve the patient's quality of life, it is very important to implement a strict program for the prevention and treatment of ulcers, as well as proper management of infections [3]. Thus, it is critical to keep diabetes patients aware of new therapies and treatments and their availability in the healthcare system. The treatment of DFUs requires a multidisciplinary approach with proper medical tools, skills, and knowledge. This starts from patient education, with the application of new classifications to guide the treatment to prevent amputations. New diagnosis methods should become available, such as the 16S ribosomal DNA sequence in bacteria, to provide a better understanding of the microbiota in DFUs. It is reported that DFU has a polymicrobial nature, and, according to its geographical location, certain marked differences, wound characteristics, antibiograms according to local epidemiology, individualized antimicrobial guided therapy, regular debridement, regular assessment of wounds, and change of dressings. The latter characteristics are also aided by new biological and molecular therapies that were proven to improve infection control, the regulation of the local inflammatory profile, and improved quality of the cicatrizing process. In the next sections, this review presents an approach for the diagnosis and treatment of DFUs, focusing on the current advances in antimicrobial therapies, such as dressings,

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Diabetic ulcer regeneration: stem cells, biomaterials, growth factors

Cited by 37 publications

References 78 publications

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

The extracts of bredigite bioceramics enhanced the pluripotency of human dental pulp cells

Diabetic Foot Ulcers: Current Advances in Antimicrobial Therapies and Emerging Treatments

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