It is estimated that around 347 million people in the world are diagnosed with diabetes mellitus. 1 Indian is one of the country with very high prevalence of diabetes in the world which is predicted to increase to 120.9 million by 2030. 2 It is estimated that approximately 23.6 million people in United States have diabetes mellitus. 3 It is predicted that 1 in 3 American adults will have diabetes by 2050. 4 Diabetes affect 3% of the UK population. 5 Diabetic foot is one of the most common and distressing complication of diabetes. This devastating complication has major medical, social and economic consequences. 5 Around 15% of diabetic patients will develop foot ulcer during their life time. 6 Around 6% of hospital admission in people who have diabetes are related to foot ulcers. 7 Every year 5% of the patients with diabetes will develop a foot ulcers. 5 Foot ulcers are known to carry a 25% risk of major amputation. Diabetic foot ulceration is known to precede amputation in 85% of the cases. 8 Around 40% of the patients presenting to hospital with diabetic foot will require some form of amputation. 9 In ABSTRACT Background: Aim of current study was to analyse major amputation occurring in patients with diabetic foot complication through the new principle and practice of diabetic foot. Methods: A 5 year retrospective study was done in a single surgical unit in department of surgery of St John's medical college, Bangalore, India. Results: 26 patients were included in this study. 76.9% of the patients who underwent major amputation had type 1 diabetic foot complications. Infected ulcers were the most common cause for major amputation. Most patients who underwent major amputation had a score ranging from 16-20. 11.54% of the patients who underwent major amputation had osteomyelitis with type 3C diabetic foot osteomyelitis being most common. Conclusions: This unique study for the first time utilizes the new Amit Jain's principle and practice of diabetic foot to study major amputation in diabetic foot. Majority of the patients who undergo major amputation in India has type 1 diabetic foot complication. Most of the patients undergoing major amputation belongs to the high risk category for major amputation.