Therapeutic outcomes evaluation of adjuvant hyperbaric oxygen therapy for non-healing diabetic foot ulcers among sudanese patients

Fadol, Ethar Mohamedalfatih; Suliman, Hayat Mohamed; Osman, Bashier; Abdalla, Safa A.; Osman, Wadah; Mohamed, Elwasila M.; Abdoon, Iman Hassan

doi:10.1016/j.dsx.2021.06.010

Cited by 7 publications

(4 citation statements)

References 44 publications

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“…HBOT also stimulates nitric oxide synthase 3 (NOS-3) in bone marrow, crucial for circulating stem progenitor cell mobilization (39). Although HBOT usage shows no adverse events statistically, potential side effects like middle ear barotrauma (2%), myopia, lung collapse, and oxygen toxicity seizures should be considered (40)(41)(42). Current studies consistently demonstrate HBOT's effectiveness in enhancing DFU healing and reducing amputations (43)(44)(45)(46) 51) supports HBOT's positive impact on venous leg ulcers, decreasing healing time, ulcer area, swelling regression time, colour improvement time, and VAS score.…”

Section: Medical Technologymentioning

confidence: 99%

Cryogenic Media in Biomedical Applications: Current Advances, Challenges, and Future Perspectives

MOKBEL,

KODRESKO,

GHAZAL

et al. 2023

In Vivo

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This paper explores the crucial role of cryogenic mediums in driving breakthroughs within the biomedical sector. The objective was to investigate, critically discuss, and present the current knowledge and state-of-the-art practices, along with the challenges and perspectives of the most common applications. Through an extensive literature review, this work aims to supplement existing research, offering a comprehensive and up-to-date understanding of the subject. Biomedical research involving cryogenic mediums is advancing on multiple fronts, including the development of advanced medical technologies, clinical treatments for life-threatening conditions, high-quality biospecimen preservation, and antimicrobial interventions in industrial food processing. These advances open new horizons and present cutting-edge opportunities for research and the medical community. While the current body of evidence showcases the impressive impact of cryogenic mediums, such as nitrogen, helium, argon, and oxygen, on

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Section: Medical Technologymentioning

confidence: 99%

Cryogenic Media in Biomedical Applications: Current Advances, Challenges, and Future Perspectives

MOKBEL,

KODRESKO,

GHAZAL

et al. 2023

In Vivo

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“…Adjuvant hyperbaric oxygen therapy (HBOT) improved ulcer healing and decreased the rate of amputation in individuals with non-healing DFUs. HBOT is a reasonably safe intervention [ 108 ]. The modified tibial transverse transport (mTTT) technology was used to treat diabetic ischemic DFU in individuals with T2DM, and the technique’s efficacy and safety were evaluated.…”

Section: Recent Upgrade In the Field Of Dfusmentioning

confidence: 99%

An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials

Baig¹,

Banu

Zehravi

et al. 2022

Life

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One of the most significant challenges of diabetes health care is diabetic foot ulcers (DFU). DFUs are more challenging to cure, and this is particularly true for people who already have a compromised immune system. Pathogenic bacteria and fungi are becoming more resistant to antibiotics, so they may be unable to fight microbial infections at the wound site with the antibiotics we have now. This article discusses the dressings, topical antibacterial treatment, medications and debridement techniques used for DFU and provides a deep discussion of DFU and its associated problems. English-language publications on DFU were gathered from many different databases, such as Scopus, Web of Science, Science Direct, Springer Nature, and Google Scholar. For the treatment of DFU, a multidisciplinary approach involving the use of diagnostic equipment, skills, and experience is required. Preventing amputations starts with patient education and the implementation of new categorization systems. The microbiota involved in DFU can be better understood using novel diagnostic techniques, such as the 16S-ribosomal DNA sequence in bacteria. This could be achieved by using new biological and molecular treatments that have been shown to help prevent infections, to control local inflammation, and to improve the healing process.

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“…DFU is said to be polymicrobial in nature and to have some distinct characteristics depending on its geographical location, such as wound characteristics, antibiograms based on local epidemiology, individualized antimicrobial-driven treatment, routine debridement, regular wound examination, and dressing changes [ 3 ]. New biological and molecular therapies that have been shown to enhance infection prevention, the management of the local inflammatory profile, and the efficiency of the cicatrizing mechanism often help with the above characteristics [ 4 – 7 ]. There are several new therapies for ulcers that are designed to speed up the healing process.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats

Quazi¹,

Patwekar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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In the present investigation, Ichnocarpus frutescens, Ficus dalhousiae, Crateva magna, Alpinia galanga, and Swertia chirata plants were selected to formulate polyherbal tea bag. The infusion obtained from these polyherbal tea bags was used to formulate 5% and 10% ointment formulation to perform its wound healing activity. The excision wound model was used to assess the wound healing activity in diabetic as well nondiabetic rats. The mean percentage closure of wound area was calculated on the 3rd, 6th, 9th, 12th, 15th, 18th, and finally 21st day. The wound healing activity of formulation was found to be significantly compared with that of the reference standard and untreated groups. The percentages of closure of excision wound area on the 21st day in diabetic animals treated with ointment formulations (F1 and F2) were found to be 93.91 ± 1.65% and 99.12 ± 5.21% respectively, whereas the chloramphenicol sodium drug solution was found to be 99.81 ± 3.16%. The percentages of closure of excision wound area in nondiabetic animals treated with ointment formulations (F1 and F2) were found to be 96.81 ± 2.04% and 98.13 ± 1.14%, respectively, whereas the chloramphenicol sodium drug solution was found to be 99.15 ± 1.41% at 21st day. Therefore, from the above results, we have concluded that this polyherbal ointment can be used clinically for the treatment of diabetic and nondiabetic wounds.

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Therapeutic outcomes evaluation of adjuvant hyperbaric oxygen therapy for non-healing diabetic foot ulcers among sudanese patients

Cited by 7 publications

References 44 publications

Cryogenic Media in Biomedical Applications: Current Advances, Challenges, and Future Perspectives

Cryogenic Media in Biomedical Applications: Current Advances, Challenges, and Future Perspectives

An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials

Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats

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