One of the most significant challenges of diabetes health care is diabetic foot ulcers (DFU). DFUs are more challenging to cure, and this is particularly true for people who already have a compromised immune system. Pathogenic bacteria and fungi are becoming more resistant to antibiotics, so they may be unable to fight microbial infections at the wound site with the antibiotics we have now. This article discusses the dressings, topical antibacterial treatment, medications and debridement techniques used for DFU and provides a deep discussion of DFU and its associated problems. English-language publications on DFU were gathered from many different databases, such as Scopus, Web of Science, Science Direct, Springer Nature, and Google Scholar. For the treatment of DFU, a multidisciplinary approach involving the use of diagnostic equipment, skills, and experience is required. Preventing amputations starts with patient education and the implementation of new categorization systems. The microbiota involved in DFU can be better understood using novel diagnostic techniques, such as the 16S-ribosomal DNA sequence in bacteria. This could be achieved by using new biological and molecular treatments that have been shown to help prevent infections, to control local inflammation, and to improve the healing process.

The deliberate assortment of information on cancer growth was performed by different populace-based disease vaults (population-based cancer registries [PBCRs]) and clinic-based cancer growth libraries (hospital-based cancer registries [HBCRs]) across India under the National Cancer Registry Program–National Center for Disease Informatics and Research of Indian Council of Medical Research since 1982. This survey analyzed the malignant growth occurrence, designs, patterns, projections, and mortality from 28 PBCRs and furthermore the stage at introduction and kind of therapy of patients with disease from 58 HBCRs (n=667,666) from the pooled investigation for the composite time frame 2012–2016. Time patterns in cancer growth rate were created as yearly percent change from 16 PBCRs (those with at least 10 years of consistent great information accessible) utilizing Joinpoint relapse. Aizawl locale (269.4) and Papumpare region (219.8) had the most elevated age changed occurrence rates among guys and females, separately. The extended number of patients with disease in India is 1,392,179 for the year 2020, and the basic five driving destinations are cancer, lung, mouth, cervix uteri, and tongue. Patterns in disease frequency rate showed an expansion on the whole locales of cancer in both genders and were high in Kamrup Metropolitan (yearly percent change, 3.8%; p<0.05). Most of the patients with cancer were analyzed at the privately progressed stage for cancer (57.0%), cervix uteri (60.0%), head and neck (66.6%), and stomach (50.8%) disease, while in cellular breakdown in the lungs, far off metastasis was dominating among guys (44.0%) and females (47.6%). This audit gives a system to surveying the status and patterns of cancer growth in India. It will manage proper help for activity to fortify endeavors to improve cancer growth avoidance and control to accomplish the public non-communicable illness targets and the reasonable advancement objectives.

Diabetes is among the most common debilitating and non-transferable diseases on the planet. The idea of using nanoparticles as a drug to treat diabetes mellitus seems intriguing. The Ag nanoparticles (Ag NPs) were effectively produced utilizing Moringa olifera (family: Moringaceae) plant extract employing a simple, cheaper, faster, and environmentally friendly green synthesis process. The antidiabetic effect of the produced Ag NPs was also tested in vivo. In the presence of plant extract, silver nitrate was converted to silver ions (Ag). XRD, FTIR, UV, XPS, and HRTEM studies characterize the formed Ag NPs. Ag NPs that have been biosynthesized, crystal nature was confirmed through XRD analysis and confirmed by UV-visible spectroscopy. FT-IR spectra were used to verify the presence of various functional groups in the biomolecules, forming and stabilizing the nanoparticles. The size of the NPS was in the range of 20-40 nm determined by HRTEM. The induction of diabetes using STZ showed increased blood glucose, cholesterol, triglycerides, LDL, VLDL, massive loss in body weight. These changes were reversed following the treatment of diabetic rats for 28 days and showed significant inhibition (p < 0.001) at a dose range of 0.2 mg/kg leaf extract and 0.2 mg/kg Ag NPs compared with the extract-treated group. These obtained results suggested that plant-mediated Ag NPs have shown promising antidiabetic and anti-hyperlipidemic activity compared to the crude extract.