Statistics of Cancer, 2020 in Indian States: A Review on the Report From National Cancer Registry Programme

Begum, Shaik Asha; S, Joshna Rani; Banu, Ahmadi; Pavani, A.; Yeruva, Veena

doi:10.22159/ajpcr.2021.v14i6.41616

Cited by 2 publications

(2 citation statements)

References 21 publications

(27 reference statements)

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“…Cancer incidence has been increasing in India, with more female than male cases reported in 2020 ( Mathur et al, 2020 ; Begum et al, 2021 ). Among female malignancies, breast cancer is ranked first ( Toi et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Integration of exome-seq and mRNA-seq using DawnRank, identified genes involved in innate immunity as drivers of breast cancer in the Indian cohort

Nirgude,

Desai,

Khanchandani

et al. 2023

PeerJ

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Genetic heterogeneity influences the prognosis and therapy of breast cancer. The cause of disease progression varies and can be addressed individually. To identify the mutations and their impact on disease progression at an individual level, we sequenced exome and transcriptome from matched normal-tumor samples. We utilised DawnRank to prioritise driver genes and identify specific mutations in Indian patients. Mutations in the C3 and HLA genes were identified as drivers of disease progression, indicating the involvement of the innate immune system. We performed immune profiling on 16 matched normal/tumor samples using CIBERSORTx. We identified CD8+ve T cells, M2 macrophages, and neutrophils to be enriched in luminal A and T cells CD4+naïve, natural killer (NK) cells activated, T follicular helper (Tfh) cells, dendritic cells activated, and neutrophils in triple-negative breast cancer (TNBC) subtypes. Weighted gene co-expression network analysis (WGCNA) revealed activation of T cell-mediated response in ER positive samples and Interleukin and Interferons in ER negative samples. WGCNA analysis also identified unique pathways for each individual, suggesting that rare mutations/expression signatures can be used to design personalised treatment.

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Section: Introductionmentioning

confidence: 99%

Integration of exome-seq and mRNA-seq using DawnRank, identified genes involved in innate immunity as drivers of breast cancer in the Indian cohort

Nirgude,

Desai,

Khanchandani

et al. 2023

PeerJ

View full text Add to dashboard Cite

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“…The incidence and mortality rate among white men is lower than among African and American men. However, the Asian race has always had the lowest incidence of PC, which can be due to low genetic susceptibility and multiple environmental factors [10,11].…”

Section: Introductionmentioning

confidence: 99%

The Role of Magnetic Resonance Spectroscopy for Prostate Cancer Diagnosis

2022

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Prostate cancer (PC) is the most common malignancy among men and is the fifth leading cause of cancer-related death in men worldwide. The present study aims to systematically review the ability of magnetic resonance spectroscopy (MRS) to differentiate between benign and malignant prostate lesions. According to the 06-PRISMA guideline, we searched in five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar without time limitation for publications related to the role of magnetic resonance spectroscopy for prostate cancer diagnosis. The searched words and terms were: “prostate cancer”, “prostatitis”, “magnetic resonance spectroscopy”, “benign prostate hyperplasia”, “malignant prostate hyperplasia”, “comparison”. Totally 1927 papers were identified by database searching. Out of these papers, 261 papers were discarded because of duplication. Of the remaining 1666 papers, 1604 papers were discarded because of the inadequate information and the ones in which the abstract was submitted in congresses as preceding papers, conferences, and editorials without full text. Out of the remaining 62 papers which were studied for eligibility, 52 papers were removed for a number of reasons including inconsistency between methods with results, incorrect interpretation of the results, poor methodology, etc. Finally, 10 papers were included in this present study. In general, based on the results of the review of articles, MRS has optimal sensitivity, specificity and accuracy in diagnosing prostate cancer and differentiating it from benign prostate hyperplasia in comparison with other diagnostic and pathological methods. Due to the small number of studies related to the sensitivity and specificity of MRS, further checking was not possible to confirm these results. Therefore, further studies in this regard are recommended.

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Statistics of Cancer, 2020 in Indian States: A Review on the Report From National Cancer Registry Programme

Cited by 2 publications

References 21 publications

Integration of exome-seq and mRNA-seq using DawnRank, identified genes involved in innate immunity as drivers of breast cancer in the Indian cohort

Integration of exome-seq and mRNA-seq using DawnRank, identified genes involved in innate immunity as drivers of breast cancer in the Indian cohort

The Role of Magnetic Resonance Spectroscopy for Prostate Cancer Diagnosis

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