Diabetic Embryopathies

Gajagowni, Saivaroon; Nair, Pooja; Bapat, Alka C; Vachharajani, Akshaya

doi:10.1542/neo.23-10-e677

Cited by 2 publications

(3 citation statements)

References 55 publications

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“…Additionally, many studies have reported significant associations of maternal obesity with congenital heart defects, neural tube defects and genitourinary defects [ 52 , 53 , 54 ]. Diabetes mellitus is a well-established direct cause of birth defects through mechanisms that affect the growing embryo, known as diabetic embryopathy [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Pattern of Birth Defects in Saudi Arabia: A Systematic Review of Observational Studies

Eltyeb,

Halawi,

Tashari

et al. 2023

Pediatric Reports

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Introduction: Birth defects are a significant concern since they can lead to permanent disability and death. This study comprehensively reviews the prevalence and patterns of birth defects in Saudi Arabia. Methods: A systematic analysis of the literature retrieved from three databases (Pub Med, Science Direct, and the Saudi digital library) published between 1989 and 2022 was performed. Observational studies that addressed the prevalence and patterns of birth defects in Saudi Arabia were chosen based on the eligibility criteria, while systematic reviews, review articles, non-relevant articles, and studies that did not fulfill the eligibility criteria were excluded. Quality and risk of bias were evaluated based on the JBI and GRADE tools, respectively. Results: We identified 26 eligible publications of 1277 records that included 297,668 patients from different regions of Saudi Arabia. The highest overall prevalence of birth defects was 46.5 per 1000 live births compared to a lowest rate of 8.6 per 1000 in one study. Several studies have reported positive associations of consanguinity, maternal folic acid supplementation, family history of birth defects or genetic abnormalities, and maternal co-morbidities. The most frequent birth defects include cardiac, genitourinary, craniofacial, and nervous system defects. Conclusion: Robust findings have improved our understanding of the prevalence and pattern of birth defects in Saudi Arabia. Importantly, future studies will likely require multicenter collaboration to arrive at appropriate sample sizes in the context of the effects of risk factors on elevated prevalence. Furthermore, quantitative data require careful evaluation in more complex statistical models.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Pattern of Birth Defects in Saudi Arabia: A Systematic Review of Observational Studies

Eltyeb,

Halawi,

Tashari

et al. 2023

Pediatric Reports

View full text Add to dashboard Cite

show abstract

“…In addition to blood glucose, embryo development also depends on the levels of cholesterol, triglycerides, and oxidative stress. 14 Oxidative stress can be teratogenic, and apoptosis after oxidative stress is related to diabetic embryopathy. Polyphenols can serve as antioxidants.…”

Section: Effects Of Polyphenols On Mothers With Maternal Diabetes And...mentioning

confidence: 99%

“…13 Maternal diabetes, whether T1DM or T2DM, can increase the risk of congenital anomalies and is a complication referred to as “diabetic embryopathy”. 14 Malformations may occur during the first 10 weeks of pregnancy (the early-organogenesis period), and almost any organ system can be affected, especially the cardiac, musculoskeletal, and central nervous systems. 15 In contrast, although the risks for adverse consequences are far lower with GDM than with PGDM, GDM can cause several perinatal complications, such as stillbirth, perinatal death, metabolic syndrome, T2DM, and cardiovascular disease; the earlier the onset, the higher the severity.…”

Section: Introductionmentioning

confidence: 99%