Effects of dietary polyphenols on maternal and fetal outcomes in maternal diabetes

Zhao, Lu; Chang, Qing; Cong, Zhangzhao; Zhang, Yalin; Liu, Zhuxi; Zhao, Yuhong

doi:10.1039/d3fo02048g

Cited by 2 publications

(1 citation statement)

References 162 publications

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“…Curcumin, the main polyphenolic substance present in the rhizomes of Curcuma longa L. [20], has been shown to interact with amyloid-β peptide and α-Syn, thus inhibiting their aggregation, deposition, and neurotoxicity [21]. Importantly, curcumin has also been recognized for its pharmacological benefits in a multitude of pathological contexts, including diabetes, cancer, and even neurodegenerative diseases [22,23].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Inhibits α-Synuclein Aggregation by Acting on Liquid–Liquid Phase Transition

Li,

Jiang,

Cao

et al. 2024

Foods

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Parkinson’s disease (PD), the second most common neurodegenerative disorder, is linked to α-synuclein (α-Syn) aggregation. Despite no specific drug being available for its treatment, curcumin, from the spice turmeric, shows promise. However, its application in PD is limited by a lack of understanding of its anti-amyloidogenic mechanisms. In this study, we first reconstructed the liquid–liquid phase separation (LLPS) of α-Syn in vitro under different conditions, which may be an initial step in entraining the pathogenic aggregation. Subsequently, we evaluated the effects of curcumin on the formation of droplets, oligomers, and aggregated fibers during the LLPS of α-synuclein, as well as its impact on the toxicity of aggregated α-synuclein to cultured cells. Importantly, we found that curcumin can inhibit amyloid formation by inhibiting the occurrence of LLPS and the subsequent formation of oligomers of α-Syn in the early stages of aggregation. Finally, the molecular dynamic simulations of interactions between α-Syn decamer fibrils and curcumin showed that van der Waal’s interactions make the largest contribution to the anti-aggregation effect of curcumin. These results may help to clarify the mechanism by which curcumin inhibits the formation of α-Syn aggregates during the development of PD.

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Section: Introductionmentioning

confidence: 99%

Curcumin Inhibits α-Synuclein Aggregation by Acting on Liquid–Liquid Phase Transition

Li,

Jiang,

Cao

et al. 2024

Foods

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MicroRNA-98: the multifaceted regulator in human cancer progression and therapy

Hazari,

Samali,

Izadpanahi

et al. 2024

Cancer Cell Int

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MicroRNA-98 (miR-98) stands as an important molecule in the intricate landscape of oncology. As a subset of microRNAs, these small non-coding RNAs have accompanied a new era in cancer research, underpinning their significant roles in tumorigenesis, metastasis, and therapeutic interventions. This review provides a comprehensive insight into the biogenesis, molecular properties, and physiological undertakings of miR-98, highlighting its double-edged role in cancer progression—acting both as a tumor promoter and suppressor. Intriguingly, miR-98 has profound implications for various aspects of cancer progression, modulating key cellular functions, including proliferation, apoptosis, and the cell cycle. Given its expression patterns, the potential of miR-98 as a diagnostic and prognostic biomarker, especially in liquid biopsies and tumor tissues, is explored, emphasizing the hurdles in translating these findings clinically. The review concludes by evaluating therapeutic avenues to modulate miR-98 expression, addressing the challenges in therapy resistance, and assessing the efficacy of miR-98 interventions. In conclusion, while miR-98’s involvement in cancer showcases promising diagnostic and therapeutic avenues, future research should pivot towards understanding its role in tumor-stroma interactions, immune modulation, and metabolic regulation, thereby unlocking novel strategies for cancer management. Graphical Abstract

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Effects of dietary polyphenols on maternal and fetal outcomes in maternal diabetes

Abstract: The incidences of short-term or long-term adverse maternal and fetal outcomes caused by maternal diabetes are increasing.

Cited by 2 publications

References 162 publications

Curcumin Inhibits α-Synuclein Aggregation by Acting on Liquid–Liquid Phase Transition

Curcumin Inhibits α-Synuclein Aggregation by Acting on Liquid–Liquid Phase Transition

MicroRNA-98: the multifaceted regulator in human cancer progression and therapy

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