Diabetic complications are associated with liver enzyme activities in people with type 1 diabetes

Arkkila, Perttu; Koskinen, Pertti; Kantola, Ilkka; Rönnemaa, Tapani; Seppänen, Eila; Viikari, Jorma

doi:10.1016/s0168-8227(00)00241-2

Cited by 83 publications

(77 citation statements)

References 14 publications

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“…Increasing the activities of these enzymes may due to leakage of the enzymes from the liver into the blood stream as a result of STZ toxicity which leads to the liver damage (72). These results are in line with Arkkila et al, (7) who reported that elevated activities of serum AST and ALT is a common sign of liver diseases and observed frequently among people with diabetes than in the general population. Oral administration of gallic acid or p-coumaric acid significantly decreased the activities of ALT and AST in treated diabetic rats as compared to normal ones.…”

Section: Discussionsupporting

confidence: 92%

“…Diabetic hepatopathy is a type of advanced liver disease which is characterized by liver cirrhosis, liver failure or the need for a liver transplant (6). Further, Arkkila et al, (7) reported that the activities of liver damage markers including, serum alanine aminotransferase (ALT) and aspartate transaminase (AST) are elevated in the untreated diabetic patients. Particularly, diabetic nephropathy is a major cause of end-stage renal disease worldwide, affects 20-40% of all patients with diabetes (type 1 and type 2) (8).…”

Section: Introductionmentioning

confidence: 99%

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Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

Abdel-Moneim

El‐Twab

Ashour

et al. 2016

IJB

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The goal of diabetes treatment is primarily to save life and alleviate symptoms and secondary to prevent long-term diabetic complications resulting from hyperglycemia. Thus, our present investigation was designed to evaluate the hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin (NA/STZ)-induced diabetic rats. Experimental type 2 diabetes was induced by a single intraperitoneal (i.p.) injection of STZ (65 mg/kg b.wt.), after 15 min of i.p. injection of NA (120 mg/kg b.wt.). Gallic acid and p-coumaric acid were orally administered to diabetic rats at a dose of 20, 40 mg/kg b.wt./day, respectively, for 6 weeks. Body weight, serum glucose, protein profile, liver function enzymes and kidney function indicators was assayed. Treatment with either gallic acid or p-coumaric acid significantly ameliorated the elevated levels of glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and uric acid. Both compounds were also found to restore total protein, albumin, and globulin as well as body weight of diabetic rats to near normal values. It can conclude that both gallic acid and p-coumaric acid have potent hypoglycemic and hepato-renal protective effects in diabetic rats. Therefore, our results suggest promising hypoglycemic agents that can attenuate the progression of diabetic hepatopathy and nephropathy.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

Abdel-Moneim

El‐Twab

Ashour

et al. 2016

IJB

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“…Significant correlation between serum GGT levels and retinopathy in Type 2 diabetic patients in our study support the findings of previous studies, which have suggested measurement of serum GGT as a valuable test for predicting microvascular complications of diabetes, such as peripheral neuropathy and retinopathy (14,15).…”

Section: Disscussionsupporting

confidence: 91%

“…In addition, they found that higher levels of GGT are associated with the severity of retinal involvement. Furthermore, Type 1 DM patients with peripheral neuropathy had higher levels of ALT and GGT than those without it (14).…”

Section: Disscussionmentioning

confidence: 87%

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Evaluation of Serum Gamma Glutamyl Transferase Levels in Diabetic Patients With and Without Retinopathy

et al. 2018

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Background: Gamma glutamyl transferase (GGT) is a liver enzyme that is involved in oxidative stress. The association between GGT levels and diabetes complications such as microalbuminuria, retinopathy, and peripheral polyneuropathy is a challenging subject. Objectives: In this study we compared GGT levels in orally treated DM type 2 patients with and without retinopathy. Methods: In this cross-sectional study that was done between the years of 2011 and 2012, 208 patients with Type 2 DM, aged 30 -86 years old, who had received oral agents, and referred to the Endocrine clinic of Emam Khomeini hospital of Urmia city were enrolled. In all patients blood pressure, body mass index, and biochemical tests including fasting blood sugar (FBS) and GGT levels were measured and an ophthalmologic exam was done. Results: From 208 patients with Type 2 DM, 26 subjects (12.5%) had diabetic retinopathy; however, 182 subjects (87.5%) did not have it. Both systolic and diastolic blood pressures were significantly higher in DM 2 patients with retinopathy than those without retinopathy (P values = 0.003 and 0.022, respectively). The mean of GGT level significantly increased in diabetic patients with retinopathy compared those DM 2 patients who did not have retinopathy (P value < 0.001). Prevalence of GGT levels greater than 45 U/l was 61.5% (n = 16) and 10.4% (n = 19) in diabetic patients with and without retinopathy, respectively (P value < 0.001). Conclusions:We suggest that diabetic retinopathy might have an association with higher GGT levels.

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Assessment of the antidiabetic and antilipidemic properties of bacillus subtilis spb1 biosurfactant in alloxan‐induced diabetic rats

et al. 2015

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The present study aimed to scrutinize the potential of Bacillus subtilis SPB1biosurfactant, orally administered, for preventing diabetic complications in rats. The findings revealed that, Bacillus subtilis biosurfactant was an effective reducer of α-amylase activity in the plasma. Moreover, this supplement helped protect the β-cells from death and damage. Both the inhibitory action of SPB1 biosurfactant on α-amylase and the protection of the pancreas' β-cells lead to a decrease of the blood glucose levels, consequently antihyperglycemic effect. Interestingly, this lipopeptide biosurfactant modulated key enzyme related to hyperlipidemia as lipase; which leads to the regulation of the lipid profile in serum by the delay in the absorption of LDL-cholesterol and triglycerides, and a significant increase in HDL-cholesterol. Histological analyses also showed that it exerted a protective action on the pancreases and efficiently preserved the liver-kidney functions of diabetic rats, evidenced by significant decreases in aspartate transaminase, alanine transaminase, gamma-glytamyl transpeptidase and lactate deshydrogenase activities in the plasma, as well as in the creatinine and urea contents. Overall, the present study demonstrated that the hypoglycemic and antilipidemic activities exhibited by Bacillus subtilis biosurfactant were effective enough to alleviate induced diabetes in experimental rats. Therefore, SPB1biosurfactant could be considered as a potential strong candidate for the treatment and prevention of diabetes.

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Diabetic complications are associated with liver enzyme activities in people with type 1 diabetes

Cited by 83 publications

References 14 publications

Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

Evaluation of Serum Gamma Glutamyl Transferase Levels in Diabetic Patients With and Without Retinopathy

Assessment of the antidiabetic and antilipidemic properties of bacillus subtilis spb1 biosurfactant in alloxan‐induced diabetic rats

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