Diabetes Mellitus and Oxidative Stress: A Co-relative and Therapeutic Approach

Chandra, Kailash; Singh, Pradeep Kumar; Dwivedi, Shridhar; Sk, Jain

doi:10.7860/jcdr/2019/40628.12878

Cited by 16 publications

(13 citation statements)

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“…Hyperglycemia can promote superoxide buildup through different metabolic pathways for instance; augmented glucose flux through the polyol pathway; increased protein glycation; protein kinase activation; hexosamine activation and decline in antioxidant defense system. Metabolic disturbance and oxidative stress which result from hyperglycemia have long been associated with neurological, urological, cardiovascular, kidney, and eye vision disorders (Chandra et al., 2019). Because of the rising number of diabetic patients and scarcity of the number of antidiabetic drugs without side effects, the efforts to find new drugs with no side effects have increased.…”

Section: Introductionmentioning

confidence: 99%

“…system. Metabolic disturbance and oxidative stress which result from hyperglycemia have long been associated with neurological, urological, cardiovascular, kidney, and eye vision disorders (Chandra et al, 2019). Because of the rising number of diabetic patients and scarcity of the number of antidiabetic drugs without side effects, the efforts to find new drugs with no side effects have increased.…”

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confidence: 99%

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In vitro antioxidant and antidiabetic activity of essential oils encapsulated in gelatin‐pectin particles against sugar, lipid and protein oxidation and amylase and glucosidase activity

Siahbalaei

Kavoosi

Shakeri

2020

Food Science & Nutrition

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

In vitro antioxidant and antidiabetic activity of essential oils encapsulated in gelatin‐pectin particles against sugar, lipid and protein oxidation and amylase and glucosidase activity

Siahbalaei

Kavoosi

Shakeri

2020

Food Science & Nutrition

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“…However, excessive free radical generation from endogenous or exogenous sources results in oxidative stress, which has major repercussions, including damage to proteins, lipids, and DNA, as evidenced by phagocytosis, neutrophil function, and, particularly, shear stress-induced vasorelaxation. Oxidative stress causes a rise in mitochondrial superoxide production in the endothelial cells of both large and small arteries and in the heart, resulting in a range of micro- and macrovascular complications ( Chandra et al, 2019 ).…”

Section: What Is Oxidative Stress and How Can It Be Managed?mentioning

confidence: 99%

The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance

Arunachalam

Sasidharan²,

Yang

2022

Front. Pharmacol.

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Diabetes mellitus is a prevalent metabolic and endocrine illness affecting people all over the world and is of serious health and financial concern. Antidiabetic medicine delivered through pharmacotherapy, including synthetic antidiabetic drugs, are known to have several negative effects. Fortunately, several natural polysaccharides have antidiabetic properties, and the use of these polysaccharides as adjuncts to conventional therapy is becoming more common, particularly in underdeveloped nations. Oxidative stress has a critical role in the development of diabetes mellitus (DM). The review of current literature presented here focusses, therefore, on the antioxidant properties of mushroom polysaccharides used in the management of diabetic complications, and discusses whether these antioxidant properties contribute to the deactivation of the oxidative stress-related signalling pathways, and to the amelioration of β-cell dysfunction and insulin resistance. In this study, we conducted a systematic review of the relevant information concerning the antioxidant and antidiabetic effects of mushrooms from electronic databases, such as PubMed, Scopus or Google Scholar, for the period 1994 to 2021. In total, 104 different polysaccharides from mushrooms have been found to have antidiabetic effects. Most of the literature on mushroom polysaccharides has demonstrated the beneficial effects of these polysaccharides on reactive oxygen and nitrogen species (RONS) levels. This review discuss the effects of these polysaccharides on hyperglycemia and other alternative antioxidant therapies for diabetic complications through their applications and limits, in order to gain a better understanding of how they can be used to treat DM. Preclinical and phytochemical investigations have found that most of the active polysaccharides extracted from mushrooms have antioxidant activity, reducing oxidative stress and preventing the development of DM. Further research is necessary to confirm whether mushroom polysaccharides can effectively alleviate hyperglycemia, and the mechanisms by which they do this, and to investigate whether these polysaccharides might be utilized as a complementary therapy for the prevention and management of DM in the future.

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“…Diabetes is a metabolic disorder characterised by elevated blood sugar that results from defects in insulin production and/or insulin action, and impaired function in the metabolism of carbohydrates, lipids and proteins which leads to macro and microvascular complications [2]. Inflammation, endothelial dysfunction, and hypercoagulability are correlated to each other, playing an important role in the development of vascular complications in diabetic patients [3].…”

Section: Introductionmentioning

confidence: 99%

“…Inflammation, endothelial dysfunction, and hypercoagulability are correlated to each other, playing an important role in the development of vascular complications in diabetic patients [3]. There is emerging evidence that oxidative stress makes a significant contribution to the progression of diabetes and its associated complications [2,4]. Flavonoids in Kirinyuh leaves have a high antioxidant activity with a concentration inhibitor value (IC50) of 9.5671 ppm and has an antioxidant capacity of 49.037% [5].…”

Section: Introductionmentioning

confidence: 99%

Activity Nanokirinyuh (Chromolaena Odorata) Leaves Extract in Alloxan Induced Diabetic Rats

Idacahyati¹,

Wulandari²,

Gustaman³

et al. 2021

Int J App Pharm

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Objective: Diabetes Mellitus is a type of degenerative disease that is increasing every year in countries around the world. Diabetes Mellitus is a major cause of blindness, kidney failure, heart attacks, and stroke. Nanokirinyuh leaves have potential as an antidiabetic because they contains chemical compounds that have antioxidant activity. The purpose of this study was to determine activity of nanokirinyuh leaves as an antidiabetic. Methods: Wistar rats as many as 24 animals were divided into 6 groups, namely the normal control group, positive control (glibenclamide 0.5 mg/Kg BW), negative control (alloxan 600 mg/BW rat), and nanochitosan kirinyuh leaves at a dose of 225 mg/Kg BW rat, 450 mg/Kg BW rat and 675 mg/Kg BW treatment was carried out for 10 d. Percent decrease of level glucose was evaluated along with histopathological investigation in various experimental groups of rats. Data analysis using the One Way Anova test and continued LSD test. Results: Level of Glucose at a dose of 675 mg/Kg BW rats showed the highest levels of the negative group and other dose groups. Pancreas histopathology test results showed that the group with a dose of 450 mg/Kg BW of rats had the lowest necrosis rate compared to the negative control group and other dose groups. Conclusion: Nanokirinyuh leaves can reduce of level plasma glucose and necrosis in a histopathology test.

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Diabetes Mellitus and Oxidative Stress: A Co-relative and Therapeutic Approach

Cited by 16 publications

References 0 publications

In vitro antioxidant and antidiabetic activity of essential oils encapsulated in gelatin‐pectin particles against sugar, lipid and protein oxidation and amylase and glucosidase activity

In vitro antioxidant and antidiabetic activity of essential oils encapsulated in gelatin‐pectin particles against sugar, lipid and protein oxidation and amylase and glucosidase activity

The Antioxidant Properties of Mushroom Polysaccharides can Potentially Mitigate Oxidative Stress, Beta-Cell Dysfunction and Insulin Resistance

Activity Nanokirinyuh (Chromolaena Odorata) Leaves Extract in Alloxan Induced Diabetic Rats

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