Diabetes control could through platelet-to-lymphocyte ratio in hemograms

Abstract

SUMMARY OBJECTIVE Association between type 2 diabetes mellitus and inflammation is well-established. We aimed to study platelet-to-lymphocyte ratio (PLR), a novel inflammatory index derived from hemogram, in diabetic patients in comparison to those in healthy volunteers. METHODS Medical data of type 2 diabetics that showed up in general outpatient medical clinics of our institution between February 2017 and August 2017 were recorded and analyzed. RESULTS Median PLR of type 2 diabetic patients was significantly higher than the PLR of healthy controls (p=0.001). Moreover, PLR was significantly and positively correlated with HbA1c (p<0.001, r=0.58), fasting plasma glucose (p<0.001, r=0.49), and c-reactive protein (p=0.003, r=0.30) levels. Type 2 diabetic subjects with proteinuria had significantly higher PLR levels than that of diabetic subjects without proteinuria. CONCLUSION As an inexpensive and easy to use index, PLR may be useful in predicting the development and control levels of type 2 diabetes mellitus. However, its correlation with HbA1c needs to be validated by larger prospective studies.

Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history

“…Previous studies have found that PLR is closely related to diabetes and can be used to assess the progress of the disease [35], predict and evaluate the diabetes-related lower limb vascular disease [15], atherosclerosis and diabetic foot ulcers [36]. However, Atak et al didn't found an association between PLR and DR [35], which might be attributed to the small sample size. In our study, though the PLR as a continuous variate didn't show independent association with DR, the highest quartile of PLR indeed adds more than 2-fold risk to the presence of DR.…”

Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history

“…Previous studies have found that PLR is closely related to diabetes and can be used to assess the progress of the disease [32], predict and evaluate the diabetes-related lower limb vascular disease [15], atherosclerosis and diabetic foot ulcers [33]. However, Atak et al didn't found an association between PLR and DR [32], which might be attributed to the small sample size. In our study, though the PLR as a continuous variate didn't show independent association with DR, the highest quartile of PLR indeed adds more than 2 fold risk to the presence of DR.…”

Correlation between the platelet‐to‐lymphocyte ratio and diabetic foot ulcer in patients with type 2 diabetes mellitus

“…This study found that the PLR of the T2DM and DFU groups was higher than that of the NC group. Atak et al also found that the PLR of patients with T2DM was higher than that of the healthy subjects, and there was a positive correlation between PLR and HbA1c 20 . These results suggested that the PLR may be helpful in predicting the development and level of glycemic control.…”

“…Atak et al also found that the PLR of patients with T2DM was higher than that of the healthy subjects, and there was a positive correlation between PLR and HbA1c. 20 These results suggested that the PLR may be helpful in predicting the development and level of glycemic control. An elevated PLR in patients with T2DM may reflect the underlying inflammatory burden of diabetes mellitus, with inflammation markers, including PLR, being elevated due to poor glycemic control and exacerbated underlying chronic low-grade inflammation.…”