Di-tri-octahedral smectite for the prevention of post-operative diarrhea in equids with surgical disease of the large intestine: Results of a randomized clinical trial

Hassel, Diana M.; Smith, Phoebe A.; Nieto, Jorge E.; Beldoménico, Pablo Martín; Spier, Sharon J.

doi:10.1016/j.tvjl.2008.06.016

Cited by 24 publications

(9 citation statements)

References 18 publications

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“…These were horses that had undergone surgical treatment of a large colon disorder, including pelvic flexure enterotomy, and a faecal scoring system was used to objectively assess outcome. There was a significant reduction in the prevalence of post operative diarrhoea in the treatment group (10.8%) vs. the placebo group (41.4%) , which would support the use of this agent to reduce the likelihood of post operative diarrhoea in horses with surgical diseases of the large colon.…”

Section: Post Operative Diarrhoeamentioning

confidence: 67%

Prevention of post operative complications following surgical treatment of equine colic: Current evidence

Salem

Proudman

Archer

2015

Equine Veterinary Journal

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Changes in management of the surgical colic patient over the last 30 years have resulted in considerable improvement in post operative survival rates. However, post operative complications remain common and these impact negatively on horse welfare, probability of survival, return to previous use and the costs of treatment. Multiple studies have investigated risk factors for post operative complications following surgical management of colic and interventions that might be effective in reducing the likelihood of these occurring. The findings from these studies are frequently contradictory and the evidence for many interventions is lacking or inconclusive. This review discusses the current available evidence and identifies areas where further studies are necessary and factors that should be taken into consideration in study design.

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Section: Post Operative Diarrhoeamentioning

confidence: 67%

Prevention of post operative complications following surgical treatment of equine colic: Current evidence

Salem

Proudman

Archer

2015

Equine Veterinary Journal

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“…Its role in the treatment of acute diarrhoea in children and adults is well established, 24,25 and a beneficial effect has been found in different types of diarrhoea and different species 21,22,26‐28 . In a case series of 17 dogs with intractable CID, 10 dogs (58.8%) had resolution of their diarrhoea after 48 to 72 hours of treatment, and improvement was noted in the remainder 29…”

Section: Introductionmentioning

confidence: 99%

Chemotherapy‐induced diarrhoea in dogs and its management with smectite: Results of a monocentric open‐label randomized clinical trial

Fournier

Serra

Williams

et al. 2020

Vet Comparative Oncology

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Chemotherapy‐induced diarrhoea (CID) is a frequent chemotherapy adverse event in dogs. Yet, there is currently no consensus regarding its management. Smectite is a natural medical clay, widely used in the treatment of acute diarrhoea in humans. The objectives of this study were to assess the efficacy of smectite in the management of CID in dogs, and to collect epidemiological data on CID. For each episode of diarrhoea, dogs were randomized into two management groups: Smectite group, receiving smectite at 0.5 g/kg PO per day divided in two to three doses initiated at the start of CID; control group, without initial medication. In both groups, rescue metronidazole was prescribed if CID progressed or was not improved within 48 hours. Sixty dogs were recruited and received 426 chemotherapy administrations between June 2017 and March 2019. The incidence rate of CID was 110/426 (25.8%, 95% CI: 21.7%‐30.2%), and significantly differed between the chemotherapeutic drugs administered (P < .001). Metronidazole was administered in 5/54 events (9.3%, 95% CI: 3.1%‐20.3%) in the smectite group and in 40/56 events (71.4%, 95% CI: 57.5%‐82.3%) in the control group (P < .001). The time to resolution of diarrhoea was shorter (P < .001) in the smectite group (median: 19.5 hours, interquartile range [IQR]: 13.5‐32 hours) compared with the control group (median: 53 hours, IQR: 31.5‐113.5 hours). The results of this study support the administration of smectite in the first‐line management of CID in dogs.

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“…The consensus and recommendations about acute gastrointestinal injury (AGI) [ 1 ] allowed us to investigate these issues. The gastrointestinal symptoms of AGI, including nausea/vomiting [ 27 ], diarrhea (three or more loose or liquid stools per day) [ 28 , 29 ], paralysis of the lower GI tract (paralytic ileus) [ 15 ], and abnormal bowel sound [ 30 ] can be observed frequently in post-operative patients undergoing laparoscopic colorectal surgery. Thus far, there has been no published study indicating whether the elevated IAP during laparoscopic surgery (generally between 12 and 15 mm Hg) is associated with postoperative AGI or is related to increased occurrence of the above-mentioned GI symptoms.…”

Section: Discussionmentioning

confidence: 99%

Does elevated intra-abdominal pressure during laparoscopic colorectal surgery cause acute gastrointestinal injury?

Cai

Malbrain

Sun

et al. 2015

Videosurgery and Other Miniinvasive Techniques

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IntroductionThe incidence of acute gastrointestinal injury (AGI) after colorectal surgery is low when laparoscopic techniques are used. While elevated intra-abdominal pressure (IAP) and intra-abdominal hypertension (IAH) are associated with AGI grade II, little is known about the relation between increased IAP during laparoscopy and subsequent AGI.AimTo assess the impact of increased IAP during laparoscopic colorectal surgery on the incidence of postoperative AGI.Material and methodsSixty-six patients (41 men and 25 women) with colorectal cancer undergoing elective laparoscopic colorectal surgery were randomized into 3 groups, according to different IAP levels during CO2 pneumoperitoneum (10 mm Hg, 12 mm Hg and 15 mm Hg). We recorded the incidence of AGI after surgery by assessing the following parameters: time to first flatus/defecation, time to first bowel movement, time to tolerance of semi-liquid food and the occurrence of vomiting/diarrhea. Moreover, inflammatory mediators were measured before the induction of CO2 pneumoperitoneum and on postoperative day 1.ResultsAcute gastrointestinal injury occurred in 15 (27.3%) patients. In all 3 study groups, the elevation of IAP during CO2 pneumoperitoneum did not significantly increase the occurrence of symptoms of AGI, vomiting or diarrhea. Lower IAP levels did not significantly accelerate recovery of gastrointestinal function or shorten postoperative hospital stay. The changes in serum IL-6 after surgery did not correlate with the value of IAP.ConclusionsThe level of IAP elevation during laparoscopic colorectal surgery does not increase the occurrence of AGI after surgery.

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Di-tri-octahedral smectite for the prevention of post-operative diarrhea in equids with surgical disease of the large intestine: Results of a randomized clinical trial

Cited by 24 publications

References 18 publications

Prevention of post operative complications following surgical treatment of equine colic: Current evidence

Prevention of post operative complications following surgical treatment of equine colic: Current evidence

Chemotherapy‐induced diarrhoea in dogs and its management with smectite: Results of a monocentric open‐label randomized clinical trial

Does elevated intra-abdominal pressure during laparoscopic colorectal surgery cause acute gastrointestinal injury?

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