DFT predictions, synthesis, stoichiometric structures and anti-diabetic activity of Cu (II) and Fe (III) complexes of quercetin, morin, and primuletin

Jabeen, Erum; Ahmed, Safeer; Murtaza, Iram; Ali, Tahir; Masood, Nosheen; Rizvi, Aysha Sarfraz; Murtaza, G.

doi:10.1016/j.molstruc.2017.09.003

Cited by 33 publications

(17 citation statements)

References 32 publications

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“…Only Qn had two clear peaks: one at 165 mV for oxidation, the other at 87 mV for reduction. After ferric ions were added into the Qn solution, the anodic peak decreased due to the formation of the Qn ‐ferric ion complex, which aligns with published findings [32]. Because the anodic and cathodic peak heights of the Qn ‐ferric ion complex were unequal, the electrochemical reaction belonging to the complex was quasi‐reversible.…”

Section: Resultssupporting

confidence: 88%

Voltammetric Method for Determining Ferric Ions with Quercetin

et al. 2021

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A novel, simple, rapid, inexpensive, highly sensitive voltammetric method developed for determining ferric ions with quercetin in water samples and iron supplements using a disposable bare pencil graphite electrode is described. The limit of detection and analytical ranges for the ferric ions were 3.6 nM and 17.9–716.0 nM, respectively. The results with the water samples were compared with those obtained from a potentiometric auto‐titration system, and the method's accuracy was tested using certified reference material. The complex stoichiometry and electrode reaction were also systematically investigated with UV‐visible spectrophotometry, 1H‐NMR spectroscopy and voltammetry.

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Section: Resultssupporting

confidence: 88%

Voltammetric Method for Determining Ferric Ions with Quercetin

et al. 2021

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“…Further, the living body contains proteins as their major part and Fls can not only scavenge free radicals but can bind with proteins too . For example, flavonoids which became the part of plasma after ingestion of a flavonoid rich meal have been demonstrated to bind to human serum albumin (HSA) .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin

et al. 2019

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The in vivo determination of radical scavenging activity of flavonoids (Fls) and their metal complexes (M‐Fls) through co‐administration of 2‐hydroxypropyl beta‐cyclodextrin (HP‐βCD) was determined. The flavonoids morin (mo), quercetin (quer), primuletin (prim), their Cu (II) and Fe (III) complexes were selected to explore their radical scavenging potential. Metal complexes of flavonoids (M‐Fls) showed better radical scavenging activity RSA when injected to rats than corresponding flavonoids. The RSA is improved in the presence of HP‐βCD. This increase in RSA was assisted by enhanced enzymatic activity of catalase (CAT) and superoxide dismutase (SOD) activity. The compounds displayed hepatoprotection against alloxan induced liver damage as flavonoid injected group displayed lower levels of enzymes and intermediates aspartate/alanine transaminase (AST), alanine aminotransferase (ALT), Lipid peroxidation (MDA), Hydroxyproline (HYP), Sailic acid (SA) and higher albumin and total proteins level compared with alloxan treated group. It was evaluated by histopathological investigations that M‐Fls restored the hepatic damage caused by alloxan. The binding constants values of the compounds with human plasma (n‐HP) revealed the order of 103‐104 L−1. The binding interactions of the compounds with human plasma in the presence of HP‐βCD is decreased which in turns increased the RSA as well as CAT and SOD activities. Based upon our results, it was concluded that radical scavenging activities and hepatoprotective activities of M‐Fls is increased when co‐administrated with HP‐βCD.

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“…The complexation behavior of quercetin for iron(III) as well as the antioxidant and anti-diabetic activity of the Fe(III)–Que complexes were also studied in methanol [ 24 , 29 ]. Interestingly, Raza et al reported on a 1:2 stoichiometric metal-to-ligand ratio, where iron chelates quercetin through site C [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…The cancer preventive and therapeutic effects of quercetin have been demonstrated through in vitro as well as in vivo experimental findings [ 21 , 22 ]. As depicted in Scheme 1 , Que consists of three phenolic rings (A, B, and C rings); it has three available sites for metal chelation including ortho-dihydroxyl (catechol) group of the B ring (site A), 5-hydroxy-4-keto group (site B), and 3-hydroxy-4-keto group (site C), since both hydroxyl and keto groups of Que have the ability to form metal complexes [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. Interestingly, it was observed that some biological properties of quercetin such as antioxidant, antibacterial, and antitumor activities, change with metal chelation.…”

Section: Introductionmentioning

confidence: 99%

A Review on Coordination Properties of Al(III) and Fe(III) toward Natural Antioxidant Molecules: Experimental and Theoretical Insights

et al. 2021

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This review focuses on the ability of some natural antioxidant molecules (i.e., hydroxycinnamic acids, coumarin-3-carboxylic acid, quercetin, luteolin and curcumin) to form Al(III)- and Fe(III)-complexes with the aim of evaluating the coordination properties from a combined experimental and theoretical point of view. Despite the contributions of previous studies on the chemical properties and biological activity of these metal complexes involving such natural antioxidants, further detailed relationships between the structure and properties are still required. In this context, the investigation on the coordination properties of Al(III) and Fe(III) toward these natural antioxidant molecules might deserve high interest to design water soluble molecule-based metal carriers that can improve the metal’s intake and/or its removal in living organisms.

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DFT predictions, synthesis, stoichiometric structures and anti-diabetic activity of Cu (II) and Fe (III) complexes of quercetin, morin, and primuletin

Cited by 33 publications

References 32 publications

Voltammetric Method for Determining Ferric Ions with Quercetin

Voltammetric Method for Determining Ferric Ions with Quercetin

Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin

A Review on Coordination Properties of Al(III) and Fe(III) toward Natural Antioxidant Molecules: Experimental and Theoretical Insights

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