Dezocine prevents sufentanil-induced cough during general anesthesia induction: A randomized controlled trial

Duan

et al. 2020

TCRM

Background: Sufentanil-induced cough is frequent during the induction of anesthesia. The aim of this research was to assess the influence of pretreatment with nalbuphine on sufentanil-induced cough. Patients and Methods: A total of 210 American Society of Anesthesiologists (ASA) I-II patients who are 18-70 years old and scheduled for elective surgery were randomly divided into two groups. Group N was pretreated with 0.3 mg/kg nalbuphine at 150 s before induction with sufentanil, and Group C received the same volume of normal saline as the placebo. We assessed the incidence and severity of cough 2 minutes after sufentanil administration. We also recorded the hemodynamic changes and side effects of sufentanil after sufentanil administration. Results: No patients had cough in group N, and 30 patients had cough in group C (degree of cough: mild 8; moderate 10; severe 12). The incidence and severity of cough in group N were significantly lower than those in group C. Conclusion: Pretreatment with 0.3 mg/kg nalbuphine significantly suppressed the incidence and intensity of sufentanil-induced cough.

Section: Discussionmentioning

confidence: 99%

<p>Pretreatment with Nalbuphine Prevents Sufentanil-Induced Cough During the Anesthesia Induction: A Randomized Controlled Trial</p>

Duan

et al. 2020

TCRM

“… 27 28 Induced cough can be reduced by propofol 29 and interestingly, by another opioid, dezocine. 30 Dezocine is an opioid analgesic acting on μ-, δ- and κ-opioid receptors and has been used in propofol sedation. 31–33 Oxycodone is an opioid alkaloid acting on μ- and κ-opioid receptors.…”

Section: Introductionmentioning

confidence: 99%

Effect of propofol combined with opioids on cough reflex suppression in gastroscopy: study protocol for a double-blind randomized controlled trial

et al. 2017

IntroductionThe best methods for inducing analgesia and sedation for gastroscopy are still debated but finding an adequate regimen of sedation/analgesia is important. Stimulation of the larynx under sedation can cause reflex responses. Propofol with opioids has been recommended for gastroscopy sedation but the effects on cough reflex suppression remain unclear. This trial will evaluate the effects of propofol combined with small doses of dezocine, oxycodone, sufentanil or fentanyl for gastroscopy. We hypothesise that better performance may be obtained with a combination of propofol and oxycodone. We will observe the incidence and degree of reflex coughing and gagging under sedation when using propofol combined with one of the above drugs or propofol alone.Methods and analysisThis will be a prospective, randomised, double-blind, controlled trial. ASA I–II level patients aged 18–65 years and scheduled for gastroscopy will be included. It is planned that 500 subjects will be randomised to intravenously receive 2–2.2 mg/kg propofol plus 0.5–0.8 μg/kg fentanyl (fentanyl group), 2–2.2 mg/kg propofol plus 0.05–0.08 μg/kg sufentanil (sufentanil group), 2–2.2 mg/kg propofol plus 0.04–0.05 mg/kg dezocine (dezocine group), 2–2.2 mg/kg propofol plus 0.04–0.05 mg/kg oxycodone (oxycodone group), or 2.4–3 mg/kg propofol plus 2–2.5 mL saline (control group) for sedation. The primary endpoint is the incidence and degree of reflex coughing and gagging. The secondary endpoints include the occurrence of discomfort or side effects, the use of jaw thrust, assisted ventilation or additional propofol, recovery time, duration of procedure and Steward score.Ethics and disseminationThis study has been approved by the Institutional Ethics Committee for Clinical Research of Zhongda Hospital, Affiliated to Southeast University (No. 2015ZDSYLL033.0). The results of the trial will be published in an international peer-reviewed journal.Trial registrationThis study has been registered with the Chinese Clinical Trial Register (No. ChiCTR-ICR-15006952).Trial statusAt the time of manuscript submission, the study was in the recruitment phase.

Proceedings of the 2016 International Conference on Mechatronics, Control and Automation Engineering

“…However, it is commonly accompanied with opioid-induced cough, respiratory depression, and postoperative nausea and vomiting during induction of general anesthesia [1]. Previous studies have found that the incidence of fentanyl-induced cough varies between 2.7% and 65% [2,3]. The tussive effect of sufentanil is usually transient and self-limited for most patients.…”

Section: Introductionmentioning

confidence: 99%

Effects of Pre-inhalation of Salbutamol on Cough Reflex Induced by Sufentanil

Li¹,

Li²

2016

Purposes: This study was designed to evaluate the effect of pre-inhalation of salbutamol aerosol(200μg) and injection speed on sufentanil-induced cough. Methods: 160 patients aged 25-62yr, ASA Ⅰ-Ⅱ, scheduled for various elective surgical procedures under general anesthesia were randomly allocated into four groups of 40 each. Group Ⅱ, Ⅳ served as control received saline aerosol, and Group Ⅰ, Ⅲ received a pre-inhalation of one metered aerosol puff of salbutamol(200μg) 10min prior to intravenous injection of sufentanil. Sufentanil 0.5μg/kg was administered within 3s in GroupⅠ, Ⅱ, or over 30s in Group Ⅲ, Ⅳ. The concentration of sufentanil was 10μg/ml. The incidences and severity of cough that occurred within 1 min after the injection of sufentanil were recorded, the HR and SBP at pre-anesthetic(T1), 5 minutes after inhalation(T2) , and 1 minute after injecting sufentanil (T3) were also recorded. Results: The incidence of cough in GroupⅠ, Ⅳ(10%,12.5%) were less than Group Ⅱ(37.5%) (p<0.05); The incidence of cough in Group Ⅲ(2.5%) was significantly lower Group Ⅱ (p<0.01). The highest non-invasive blood (NIBP) and heart rate (HR) were at T3 timepoint in Group Ⅱ(p<0.05). Conclusions: The pre-inhalation of salbutamol(200μg) combined with a prolonged injection time significantly reduced the incidence of sufentanil-induced.