<p>Pretreatment with Nalbuphine Prevents Sufentanil-Induced Cough During the Anesthesia Induction: A Randomized Controlled Trial</p>

Abstract

Background: Sufentanil-induced cough is frequent during the induction of anesthesia. The aim of this research was to assess the influence of pretreatment with nalbuphine on sufentanil-induced cough. Patients and Methods: A total of 210 American Society of Anesthesiologists (ASA) I-II patients who are 18-70 years old and scheduled for elective surgery were randomly divided into two groups. Group N was pretreated with 0.3 mg/kg nalbuphine at 150 s before induction with sufentanil, and Group C received the same volume of normal saline as the placebo. We assessed the incidence and severity of cough 2 minutes after sufentanil administration. We also recorded the hemodynamic changes and side effects of sufentanil after sufentanil administration. Results: No patients had cough in group N, and 30 patients had cough in group C (degree of cough: mild 8; moderate 10; severe 12). The incidence and severity of cough in group N were significantly lower than those in group C. Conclusion: Pretreatment with 0.3 mg/kg nalbuphine significantly suppressed the incidence and intensity of sufentanil-induced cough.

WITHDRAWN: Comparison of a small dose of oxycodone and sufentanil for the prevention of sufentanil-induced cough during general anesthesia induction: a prospective randomized controlled trial

“…Explosive cough may increase intraabdominal pressure and increase the risk of regurgitation and aspiration [5]. Clinical interventions have been reported to reduce SIC [1][2][3][6][7][8][9][10][11][12][13], including pretreatment with drugs (butorphanol, dezocine, remifentanil and dexmedetomidine), changing the administration route or diluting the concentration of sufentanil. However, the interventions were restricted in clinical use due to several side effects, such as long onset time, bradycardia, and respiratory depression.…”

Comparison of a Small Dose of Oxycodone and Sufentanil for the Prevention of Sufentanil-Induced Cough during General Anesthesia Induction: A Prospective Randomized Controlled Trial

“…Explosive coughs may increase intra-abdominal pressure, increasing the risk of regurgitation and aspiration [5]. Clinical interventions, such as pretreatment with drugs (butorphanol, dezocine, remifentanil, and dexmedetomidine), changing the administration route or diluting the concentration of sufentanil, have been reported to reduce SIC [1][2][3][6][7][8][9][10][11][12][13]. However, the interventions could not be widely implemented in clinical practice due to several side effects such as long onset time, bradycardia, and respiratory depression.…”

Dezocine prevents sufentanil-induced cough during general anesthesia induction: a meta-analysis of randomised controlled trials

“…Due to different doses, routes of use, and population, opioids may have a series of adverse effects, such as nausea, vomiting, cough, addiction, urinary retention, and even respiratory depression [2]. Studies have shown that the incidence of cough caused by fentanyl, remifentanil, and sufentanil was 32% [3], 27.6% [4], and 28.5% [5], respectively. Coughing caused by the application of sufentanil is called sufentanil-induced cough (SIC) [6].…”

“…SIC is generally transient, self-limiting, and benign in general anesthesia [8,9]. According to the number of coughs recorded, the severity of cough was divided into mild (1)(2), moderate (3)(4)(5) and severe (> 5) [6]. Studies have shown that SIC occurs mostly within 1 min of intravenous injection of opioids [6,10,11].…”