Dextran nanoparticles: Preparation and applications

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

“…Due to its advantageous properties, such as biodegradability, biocompatibility, non-toxicity, and non-immunogenicity, it is considered as a suitable biomaterial for the preparation of polysaccharide nanoparticles as delivery systems for various therapeutic agents, including proteins and nucleic acids. Moreover, dextran nanoparticles successfully reduce the potential negative side effects of incorporated substances by delivering them to the target sites in a controlled manner [ 262 , 263 , 264 ].…”

Fluorescent Dextran Applications in Renal Intravital Microscopy

“…This constraint drastically minimizes the probability of naturally occurring multiphoton phenomena. To illustrate this point, if we expose a rhodamine molecule to direct sunlight, we can expect a one-photon excitatory event to occur within a timeframe of 1-2 seconds, whereas a two-photon event would occur after 10 million years [6,11]. These depictions were revealed in 1931 by Dr. Marie Groppert-Mayer.…”

“…These compounds can be prepared in a wide range of molecular weights to support their application throughout the vasculature. For instance, intravascular infusions of relatively large molecular weight dextrans have been used as plasma expanders in hypovolemic treatments, substitutes for whole blood in cases of severe shock, and a mode to combat volume depletion in various conditions [1][2][3][4][5][6][7]. In contrast, low molecular weight dextrans, which can be filtered by the glomerulus and reclaimed by the tubules, have found use in nephropathology evaluations in experimental and clinical approaches [8][9][10][11][12][13][14][15][16][17].…”

“…In contrast, low molecular weight dextrans, which can be filtered by the glomerulus and reclaimed by the tubules, have found use in nephropathology evaluations in experimental and clinical approaches [8][9][10][11][12][13][14][15][16][17]. Moreover, within other branches of the medical industry, these complex branched glucans possess properties that support anticoagulation and allow them to be effectively used as vehicles for the targeted and sustained delivery of drugs, proteins, enzymes, and imaging agents [6,18].…”