Dexmedetomidine prolongs the effect of bupivacaine in supraclavicular brachial plexus block

Agarwal, Sandhya; Aggarwal, R.; Gupta, Praveen

doi:10.4103/0970-9185.125701

Cited by 141 publications

(144 citation statements)

References 28 publications

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…Gandhi et al [20] reported that the onset time of sensory and motor block was shorter in the groups for which 38 ml of 0.25% bupivacaine and 30 µg of dexmedetomidine were added than the groups for which dexmedetomidine was not added; however, the duration of analgesia, motor and sensory block was about 4-6 times longer in the groups for which dexmedetomidine was given. Agarwal et al [15] reported that, with the use of 30 ml of 0.325% bupivacaine and 100 µg of dexmedetomidine, sensory and motor block onset time in the group for which dexmedetomidine was added was shorter, in contrast with the findings of Gandhi et al [20], but that the duration of analgesia, sensory and motor block was similarly longer.…”

Section: Discussioncontrasting

confidence: 55%

“…Many studies have reported that the addition of dexmedetomidine to a local anesthetic as an adjuvant in ultrasound-guided supraclavicular brachial plexus block application increases the duration of sensory and motor block [8,9,14,15,20]. Gandhi et al [20] reported that the onset time of sensory and motor block was shorter in the groups for which 38 ml of 0.25% bupivacaine and 30 µg of dexmedetomidine were added than the groups for which dexmedetomidine was not added; however, the duration of analgesia, motor and sensory block was about 4-6 times longer in the groups for which dexmedetomidine was given.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Addition of dexmedetomidine to bupivacaine in supraclavicular brachial plexus block

Aksu

Biçer

2017

CIM

View full text Add to dashboard Cite

Addition of dexmedetomidine to bupivacaine in supraclavicular brachial plexus block Abstract Purpose: Research is ongoing to determine the lowest dose of local anesthetics in brachial plexus block that provides adequate anesthesia and postoperative analgesia and reduces complications related to local anesthetics. Methods:Patients 18-65 years of age who underwent upper limb surgery and who received ultrasound-guided supraclavicular brachial plexus block at the Erciyes University Faculty of Medicine Hospital between February 2014 and January 2015 were included in the study (n=50). Supraclavicular brachial plexus blocks were performed on Group B cases by adding 30 ml 0.33% bupivacaine and on Group BD cases by adding 15 ml 0.33% bupivacaine and 1 µg / kg dexmedetomidine. Block success was evaluated by the onset and block duration of motor and sensory block and the duration of analgesia. Results:The block success of Group B and Group BD was 92.6% and 89.3%, respectively (P = 1.000). Onset time of sensory block, degree of sensory block, duration of sensory block, onset time of motor block, degree of motor block and duration of motor block were similar in both groups in the intergroup comparison (P > 0.05). Duration of analgesia and the operative conditions of groups were similar (P > 0.05). Conclusions:In the implementation of ultrasound-guided supraclavicular brachial plexus block, block success, sensory and motor block and analgesia duration were similar for patients anaesthetized with 30 ml of bupivacaine in comparison with dexmedetomidine+bupivacaine (when the bupivacaine dose was reduced by 50% by the addition of the adjuvant).

show abstract

Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Addition of dexmedetomidine to bupivacaine in supraclavicular brachial plexus block

Aksu

Biçer

2017

CIM

View full text Add to dashboard Cite

show abstract

“…AgarwalSandhya et al (26) in their study showed that dexmedetomidine is a useful adjuvant to bupivacaine in brachial plexus block. Swami et al (27) compared clonidine and dexmedetomidine as an adjuvant to local anaesthetic agent in supraclavicular brachial plexus block with respect to onset and duration of sensory and motor block and duration of analgesia.…”

Section: Figurementioning

confidence: 99%

Dexmedetomidine and Clonidine as Adjuvants to Levobupivacaine in Supraclavicular Brachial Plexus Block: A Comparative Randomised Prospective Controlled Study

Gunasekaran¹,

Sudheer²,

Sahajananda³

et al. 2015

jemds

View full text Add to dashboard Cite

BACKGROUND:There are always efforts to find better and safer local anaesthetics along with adjuvants for supraclavicular brachial plexus block. Levobupivacaine, has strongly emerged as a safer alternative for regional anesthesia than its racemic sibling, bupivacaine. Alpha 2 agonists are combined with local anaesthetics to improve the quality of regional anesthesia. AIMS AND OBJECTIVES: This study was conducted to evaluate and compare the onset, duration of sensory and motor blockade along with the duration of analgesia between dexmedetomidine and clonidine when administered along with 0.5% levobupivacaine in supraclavicular brachial plexus block for upper limb orthopaedic surgeries. MATERIALS AND METHODS: A prospective randomized study was carried out in the department of Anaesthesia at Rajarajeswari Medical College and Hospital which included 50 adult patients between the ages of 20 and 50 years (of ASA I/II grade) who underwent upper limb orthopaedic surgeries. The patients were randomly allocated into two groups; levobupivacaine + dexmedetomidine (LD) and levobupivacaine + clonidine (LC), comprising of 25 patients each. Group LD was administered 30 ml of 0.5% levobupivacaine and 1µg/kg of dexmedetomidine, while group LC received admixture of 30 ml of 0.5% levobupivacaine and 1 µg/kg of Clonidine. Onset, duration of sensory and motor blockade and duration of analgesia were observed. STATISTICAL ANALYSIS: Statistical analysis was done using student t test, chi-square test and Fisher Exact test. The Statistical Software namely SAS 9.2, SPSS 15.0, Stata 10.1, MedCalc 9.0.1, Sysatat 12.0 and R environment ver.2.11.1 were also used for the analysis of the data and Microsoft word and Excel have been used to generate graphs, tables etc. The value of P <0.05 was considered significant and P < 0.001 as highly significant. RESULTS: The onset of sensory and motor blockade was faster in Group LD when compared to Group LC. The duration of sensory blockade, motor blockade and analgesia was longer in Group LD when compared to Group LC (p <0.001). Sedation scores were better in LD group. (p<0.05). CONCLUSION: Dexmedetomidine is a better adjuvant than Clonidine when added to Levobupivacaine in supraclavicular brachial plexus block as it prolongs the duration of sensory and motor blockade as well as the duration of analgesia.

show abstract

“…[22][23][24] The main advantage of simultaneous use of an adjuvant compound is to reduce the dose and frequency of administration of the main active drug, thus reducing side effects. 22,23,25 Clonidine, a centrally acting α 2 -adrenoceptor agonist, is administrated as an adjuvant of analgesic and hypnotic compounds. However, its main disadvantages are the incidence of hypotension.…”

Section: Introductionmentioning

confidence: 99%

Preparative Separation and Structural Identification of Impurities of a New α2‑Adrenoceptor Agonist Using Stacking Injection, LC-MSn and LC-SPE-NMR

Cardoso

Thomasi

Venâncio

et al. 2016

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Identifying impurities in drug substances has become one of the most important issues in pharmaceutical analysis since it can have a significant impact on the efficacy of new pharmaceutical products. Due to the purity requirements, in this paper a new synthetic α 2 -adrenoceptor agonist, called LPSF-PT-31, was purified and its impurities were characterized by liquid chromatographymultistage mass spectrometry (LC-MS n ) and liquid chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR). The purification step was conducted using a semi-preparative liquid chromatography and stacked injections as a new approach to drug purification. As a result, a total yield of 75% of the pure LPSF-PT-31 and 2.9 L day -1 in solvent reduction was obtained. The combination of semi-preparative stacking injection, LC-MS n , and LC-SPE-NMR, demonstrated to be efficient to purify active drugs and unambiguously identify its impurities. In addition, isolation and identification of drug impurities in the early stages of development can improve the synthetic pathway, preventing the formation of impurities or minimizing this formation to minimum levels.

show abstract

Dexmedetomidine prolongs the effect of bupivacaine in supraclavicular brachial plexus block

Cited by 141 publications

References 28 publications

Addition of dexmedetomidine to bupivacaine in supraclavicular brachial plexus block

Addition of dexmedetomidine to bupivacaine in supraclavicular brachial plexus block

Dexmedetomidine and Clonidine as Adjuvants to Levobupivacaine in Supraclavicular Brachial Plexus Block: A Comparative Randomised Prospective Controlled Study

Preparative Separation and Structural Identification of Impurities of a New α2‑Adrenoceptor Agonist Using Stacking Injection, LC-MSn and LC-SPE-NMR

Contact Info

Product

Resources

About