Dexmedetomidine and Magnesium Sulfate: A Good Combination Treatment for Acute Lung Injury?

Güzel, Abdulmenap; Doğan, Erdal; Türkçü, Gül; Kuyumcu, Mahir; Kaplan, İbrahim; Çelik, Feyzi; Yıldırım, Zeynep Baysal

doi:10.1080/08941939.2017.1422575

Cited by 18 publications

(23 citation statements)

References 44 publications

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“…Magnesium sulfate inhibits inflammatory molecules including chemokine (macrophage inflammatory protein-2), cytokine (Interleukin-6, IL-6), prostaglandin E2, and cyclooxygenase-2 in lung tissue possibly by inhibiting L-type calcium channels ( Kao et al, 2011 ). In a model of acute lung injury, magnesium sulfate (150 mg/kg, intraperitoneally) ameliorates hydrochloric acid-induced lung histopathology including peribronchial inﬂammatory cell infiltration, alveolar septal infiltration, alveolar edema, and alveolar exudation ( Güzel et al, 2019 ). It also significantly restores oxidative stress and inflammatory response in lipopolysaccharides-induced acute lung injury of mice ( Li et al, 2019 ).…”

Section: Prevention and Treatment Of Magnesium For Lung Symptoms And mentioning

confidence: 99%

“… Lung injury Kao et al (2011) - Sprague-Dawley rats Magnesium sulfate infusion Intravenous injection of 10, 50, or 100 mg/kg magnesium sulfate Magnesium sulfate attenuates oxidative stress, inflammation, and lung injury induced by lower limb ischemia-reperfusion; magnesium sulfate mitigates lung injury induced by bilateral lower limb ischemia-reperfusion in rats, possibly inhibiting L-type calcium channels. Güzel et al (2019) - Sprague-Dawley rats Magnesium sulfate infusion Intraperitoneal injection of magnesium sulfate at 150 mg/kg Magnesium sulfate and dexmedetomidine ameliorates hydrochloric acid-induced acute lung injury vis anti-oxidation and anti-inflammation; magnesium sulfate shows greater improvement in the pathology of acute lung injury than dexmedetomidine. Note: [a] No country is mentioned in the paper.…”

Section: Prevention and Treatment Of Magnesium For Lung Symptoms And mentioning

confidence: 99%

“…Magnesium sulfate as a calcium antagonist is commonly used to inhibit bronchial smooth muscle contraction and promote bronchodilation ( Hirota et al, 1999 ; Landon and Young, 1993 ; Torres et al, 2012 ). It also decreases inflammatory response and oxidative stress, as well as improves lung inflammation possibly by inhibiting IL-6 pathway, NF-κB pathway, and L-type calcium channels ( Güzel et al, 2019 ; Kao et al, 2011 ). Therefore, magnesium sulfate has a good application prospect in controlling pulmonary symptoms.…”

Section: The Possibility Of the Use Of Magnesium Supplementation In Tmentioning

confidence: 99%

“…Magnesium, an essential substance for basic biochemical reaction, participates in a cluster of normal physiological function and metabolism, such as the transport of potassium ion or calcium ion ( Flatman, 1984 ; Komiya and Runnels, 2015 ), energy metabolism, protein and nucleic acid synthesis ( Ohyama, 2019 ; Sissi and Palumbo, 2009 ). Magnesium also has anti-inflammation ( Abiri and Vafa, 2020 ; Eshraghi et al, 2015 ; Han et al, 2018 ; Kao et al, 2011 ; Ozen et al, 2020 ; Rochelson et al, 2007 ; Turner et al, 2017 ), anti-oxidation ( Güzel et al, 2019 ; Kao et al, 2011 ), anti-spasm ( Güzel et al, 2019 ; Yen and Thwaites, 2019 ), vasodilation ( Shimosawa et al, 2004 ; Wang et al, 2019 ), and neuroprotection ( Bachnas et al, 2019 ; Jameson and Bernstein, 2019 ). Therefore, magnesium homeostasis regulates reproductive system, cardiovascular system, digestive system, neurological system and respiratory system, etc, maintaining normal human health.…”

Section: Introductionmentioning

confidence: 99%

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Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Tang

Ding

Jiao

et al. 2020

European Journal of Pharmacology

100

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Magnesium as an enzymatic activator is essential for various physiological functions such as cell cycle, metabolic regulation, muscle contraction, and vasomotor tone. A growing body of evidence supports that magnesium supplementation (mainly magnesium sulfate and magnesium oxide) prevents or treats various types of disorders or diseases related to respiratory system, reproductive system, nervous system, digestive system, and cardiovascular system as well as kidney injury, diabetes and cancer. The ongoing pandemic coronavirus disease 19 (COVID-19) characterized by respiratory tract symptoms with different degrees of important organ and tissue damages has attracted global attention. Particularly, effective drugs are still lacking in the COVID-19 therapy. In this review, we find and summarize the effectiveness of magnesium supplementation on the disorders or diseases, and provide a reference to the possibility of magnesium supplementation for supportive treatment in patients with COVID-19.

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Section: Prevention and Treatment Of Magnesium For Lung Symptoms And mentioning

confidence: 99%

Section: Prevention and Treatment Of Magnesium For Lung Symptoms And mentioning

confidence: 99%

Section: The Possibility Of the Use Of Magnesium Supplementation In Tmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Tang

Ding

Jiao

et al. 2020

European Journal of Pharmacology

100

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“…In clinics, Dex is used as an anxiety reducing, sedative, and pain medication. Recently, several studies have reported that Dex could be used to attenuate acute lung injury in animal models …”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury by targeting NLRP3 via miR‐381

Zhang

Wang

Liu

et al. 2018

J Biochem & Molecular Tox

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Dexmedetomidine (Dex) is an agonist of α2-adrenergic receptors, and it is used as an anxiety reducing, sedative, and pain medication in clinical. Studies have shown that dexmedetomidine protects against lipopolysaccharide (LPS)-induced acute lung injury; however, the underlying mechanism is still unclear. To investigate, an acute lung injury mouse model was induced by intraperitoneal injection of LPS. Histopathological changes were determined by hematoxylin and eosin staining. Enzyme-linked immunosorbent assay was used to detect cytokines in serum. microRNA expression levels were detected by quantitative reverse transcription polymerase chain reaction. Protein levels were detected by western blot. Dex treatment significantly attenuated lung injury and inhibited the expression levels of the inflammation factors via reducing the level of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) and autocleavage of caspase-1. Moreover, mmu-miR-381, which targets the mRNA of NLRP3, was upregulated after Dex treatment. Dex attenuates LPS-induced acute lung injury via miR-381-targeted NLRP3.

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Preventative and therapeutic potential of animal milk components against COVID‐19: A comprehensive review

Singh¹,

Hernandez-Rauda

Peña‐Rodas

2023

Food Science & Nutrition

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The global pandemic of COVID‐19 is considered one of the most catastrophic events on earth. During the pandemic, food ingredients may play crucial roles in preventing infectious diseases and sustaining people's general health and well‐being. Animal milk acts as a super food since it has the capacity to minimize the occurrence of viral infections due to inherent antiviral properties of its ingredients. SARS‐CoV‐2 virus infection can be prevented by immune‐enhancing and antiviral properties of caseins, α‐lactalbumin, β‐lactoglobulin, mucin, lactoferrin, lysozyme, lactoperoxidase, oligosaccharides, glycosaminoglycans, and glycerol monolaurate. Some of the milk proteins (i.e., lactoferrin) may work synergistically with antiviral medications (e.g., remdesivir), and enhance the effectiveness of treatment in this disease. Cytokine storm during COVID‐19 can be managed by casein hydrolyzates, lactoferrin, lysozyme, and lactoperoxidase. Thrombus formation can be prevented by casoplatelins as these can inhibit human platelet aggregation. Milk vitamins (i.e., A, D, E, and B complexes) and minerals (i.e., Ca, P, Mg, Zn, and Se) can have significantly positive effects on boosting the immunity and health status of individuals. In addition, certain vitamins and minerals can also act as antioxidants, anti‐inflammatory, and antivirals. Thus, the overall effect of milk might be a result of synergistic antiviral effects and host immunomodulator activities from multiple components. Due to multiple overlapping functions of milk ingredients, they can play vital and synergistic roles in prevention as well as supportive agents during principle therapy of COVID‐19.

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Dexmedetomidine and Magnesium Sulfate: A Good Combination Treatment for Acute Lung Injury?

Abstract: The antioxidant and anti-inflammatory effects of Dex and MgSO ameliorated the detrimental effects of HCI-induced ALI. However, adverse effects on hemodynamics and lung damage were observed when the two drugs were administered together.

Cited by 18 publications

References 44 publications

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury by targeting NLRP3 via miR‐381

Preventative and therapeutic potential of animal milk components against COVID‐19: A comprehensive review

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