Dexlansoprazole in the Treatment of Esophagitis and Gastroesophageal Reflux Disease

Abstract

Dexlansoprazole provides another treatment option for the management of EE and symptoms of heartburn. Considering that the cost of dexlansoprazole is not favorable, further studies evaluating potential advantages over other agents are necessary to define the role of dexlansoprazole in the treatment of these conditions.

Synthesis and Green Metric Evaluation of 2-(Chloromethyl)-3-Methyl-4-(Methylsulfonyl)Pyridine

“…Total conversion of the product was attained in 24 h. After cooling the reaction mixture to room temperature, solids was thrown out which was filtered and dried at the pump to obtain 4-Methanesulfonyl-2, 3-dimethyl-pyridine-N-oxide 5. 6 To a stirred solution of acetonitrile (45 mL) containing 4-Methanesulfonyl-2, 3-dimethyl-pyridine-1-oxide 5 (5g, 24.84 mmol) was added RuCl 3 x3H 2 O (5.15g, 24.82 mmol) and heated to 85 o C for 1h. The completion of the reaction was judged by, the solvent was concentrated and the obtained residue was treated with water (50 mL), made alkaline with 25% aqueous ammonia (20 mL) and extracted with dichloromethane (35 mL).…”

“…Later on this drug (dex) was accepted by Canada and Mexico in 2010 and 2011, respectively 5 . In the clinical administration, Dex exhibited lower elimination rate, excellent dominance in higher efficacy and less side effects than S-(-)-lansoprazole (levo) 6 .…”

Synthetic approaches to the 2009 new drugs

“…9 Dexlansoprazole is a delayed release capsule for the oncedaily, oral treatment of heartburn associated with symptomatic non-erosive gastroesophageal reflux disease (GERD), the healing of erosive esophagitis (EE) and the maintenance of healed EE. 31,32 The dual release formulation is designed to provide two separate releases of medication, one at 1-2 h and then another at 4-5 h after treatment, for extended efficacy in the treatment of GERD. 33 Similar to the synthesis of the chiral sulfoxide of armodafinil vide supra, the preparation of the chiral sulfoxide of lansoprazole utilized the catalytic oxidation method developed by Kagan and co-workers (Scheme 6).…”

“…The synthesis of dronedarone relies on the preparation of the benzofuran core 34, of which three main routes have been reported, but two possess obvious overlap and are considered more process-amenable. 37 Starting from methyl 2-(2-formylphenoxy)hexanoate (32), this aldehyde can either be nitrated, then saponified or saponified and then nitrated to procure nitroacid 33 (Scheme 7). The benzofuran ring is then secured through the use of acetic anhydride and base in the presence of DMF at elevated temperature.…”

Patient Adherence in the Treatment of Gastroesophageal Reflux Disease: Proton Pump Inhibitors Versus Histamine-2 Receptor Antagonists

“…Current studies suggest that all PPIs are equally efficacious in the treatment of GERD symptoms. 13,14 Typical dosing frequency of PPIs for the treatment of GERD is once daily. 4 Common side effects among the class include abdominal pain, nausea, flatulence and diarrhea.…”