Device implant based on poly (lactic acid) with vitamin E for vaccine delivery system in Tilapia: Study for biocompatibility and biodegradation

Conde, Gabriel; Aracati, Mayumi Fernanda; Rodrigues, Letícia Franchin; Oliveira, Susana Luporini de; Costa, Camila Carlino da; Charlie-Silva, Ives; Ruiz, Thalles Fernando Rocha; Taboga, Sebastião Roberto; Belo, Marco Antônio de Andrade

doi:10.1016/j.fsirep.2022.100060

Cited by 2 publications

(4 citation statements)

References 64 publications

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“…These findings suggest that this macrocyclic lactone may have irritated the intestinal mucosa and resulted in inflammatory changes. The increase in circulating leukocytes is a typical response during the course of both chronic and acute inflammatory reactions (Charlie- Silva et al, 2020;Aracati et al 2022;Conde et al, 2022). Similar results with the increase in circulating leukocytes were observed by other authors, such as Ogueji et al (2019) who studied the exposure of African catfish (Clarias gariepinus) to ivermectin at concentrations of 9 to 25 µg/L−1.…”

Section: Discussionsupporting

confidence: 73%

“…In the evaluation of liver somatic analysis, a significant decrease was observed in animals from different treatments, possibly due to prolonged exposure to higher concentrations of ivermectin. Liver somatic index can indicate the harmful effects of chemical stressors on fish growth and physiology (Ucán-Marín et al, 2012;Corsi et al, 2003). In mammals, De Marco et al (2002) had already observed a rapid reduction in the hepatic somatic index during brief exposure to ivermectin.…”

Section: Discussionmentioning

confidence: 99%

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CLINICAL SAFETY OF IVERMECTIN TREATMENT IN NILE TILAPIA, Oreochromis niloticus

SILVA,

OLIVEIRA,

COSTA

et al. 2023

Ars Vet

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Ivermectin belongs to the group of avermectins, a group of macrocyclic lactones produced by Streptomyces avermitilis, this drug is widely used in the treatment of endoparasitoses and ectoparasitosis in different species of mammals around the world. Based on this need to develop an adequate sanitary management of fish farms and the therapeutic importance of macrocyclic lactones, this study aimed to evaluate the clinical safety of ivermectin administered orally as part of the feed for Nile tilapia (O. niloticus). For this, 56 tilapias (O. niloticus), ±100g, were placed in 7 aquariums (n=8) with a capacity of 100 L of water, supplied with running water devoid of chlorine, with the following treatments being preserved: T0 (Control, untreated), T1 and T2 (treated with 125 and 625µg/kg-1 of ivermectin, respectively). Blood samples were collected for hemogram, leukogram and evaluation of serum biochemical parameters, in addition to organs such as spleen, liver and kidneys (cranial and caudal) for somatic evaluation. The results admired an increase in serum levels of ALT, AST and glycemia, a reduction in cholesterol and triglyceride values at the highest dose, in addition to a decrease in total protein levels and liver somatic analysis. There was no change in hematological parameters, while the leukocyte profile indicated a significant increase in total leukocytes in treated tilapia with lymphocytosis and neutrophilia.. Therefore, treatment with high doses of ivermectin can harm the health of Nile tilapia, requiring additional studies to establish safe therapeutic protocols for these animals.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

CLINICAL SAFETY OF IVERMECTIN TREATMENT IN NILE TILAPIA, Oreochromis niloticus

SILVA,

OLIVEIRA,

COSTA

et al. 2023

Ars Vet

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“…The degradation rate of this polymer can be easily adjusted by variation of the initial molecular weight, the ratio of glycolide and lactide copolymers, and its crystallinity . PLA polymer is an excellent example of a vaccine delivery system based on synthetic polymers that shows slow and continuous release . It can have very different degradation rates from less than 2 months to more than 2 years .…”

Section: Cargo Release Mechanisms and Effective Parametersmentioning

confidence: 99%

“…68 PLA polymer is an excellent example of a vaccine delivery system based on synthetic polymers that shows slow and continuous release. 69 It can have very different degradation rates from less than 2 months to more than 2 years. 70 Sometimes, combining two or more polymers is applied to provide suitable physical properties and tailored degradation rates.…”

Section: Cargo Release Mechanisms and Effective Parametersmentioning

confidence: 99%

Long-Term Vaccine Delivery and Immunological Responses Using Biodegradable Polymer-Based Carriers

Malek-Khatabi

Tabandeh

Nouri

et al. 2022

ACS Appl. Bio Mater.

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Biodegradable polymers are largely employed in the biomedical field, ranging from tissue regeneration to drug/vaccine delivery. The biodegradable polymers are highly biocompatible and possess negligible toxicity. In addition, biomaterial-based vaccines possess adjuvant properties, thereby enhancing immune responses. This Review introduces the use of different biodegradable polymers and their degradation mechanism. Different kinds of vaccines, as well as the interaction between the carriers with the immune system, then are highlighted. Natural and synthetic biodegradable micro-/nanoplatforms, hydrogels, and scaffolds for local or targeted and controlled vaccine release are subsequently discussed.

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Device implant based on poly (lactic acid) with vitamin E for vaccine delivery system in Tilapia: Study for biocompatibility and biodegradation

Cited by 2 publications

References 64 publications

CLINICAL SAFETY OF IVERMECTIN TREATMENT IN NILE TILAPIA, Oreochromis niloticus

CLINICAL SAFETY OF IVERMECTIN TREATMENT IN NILE TILAPIA, Oreochromis niloticus

Long-Term Vaccine Delivery and Immunological Responses Using Biodegradable Polymer-Based Carriers

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