Developmental pattern of fetal growth hormone, insulin-like growth factor I, growth hormone binding protein and insulin-like growth factor binding protein-3

Pirazzoli, P; Cacciari, E; Iasio, Rosaria De; Pittalis, M C; Dallacasa, P; Zucchini, Stefano; Gualandi, Stefano; Salardi, S; David, C; Boschi, Stefano

doi:10.1136/fn.77.2.f100

Cited by 15 publications

(15 citation statements)

References 36 publications

(31 reference statements)

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“…The lower serum IGF-I levels among the most preterm infants at birth had no association with the attained mean value of serum IGF-I at wk 30 -33 PMA. However, there was a significant association with PMA and IGF-I, reflecting the physiologic development over time (7,13,14).…”

Section: Discussionmentioning

confidence: 98%

“…As in children and adults, IGFBP-3 is the principal carrier of IGF-I during late intrauterine life (11,12). Preterm infants have lower serum levels of IGF-I than term infants, and size at birth is correlated with the level of IGF-I in cord serum (7,13,14). Therefore, infants born SGA have lower IGF-I values than infants born AGA (5,10,13,(15)(16)(17).…”

mentioning

confidence: 99%

“…Receptors for IGF-I are found in various tissues early in gestation (3), and fetal tissues seem to have enhanced sensitivity to IGF-I compared with later in life (4). Using cordocenteses, it has been possible to determine the "normal" range of IGF-I in fetal serum and to define a positive correlation between serum concentration of IGF-I and gestational age (5)(6)(7)(8)(9)(10). IGF-I levels are similar in arterial and venous cord serum, suggesting a fetal origin (1).…”

mentioning

confidence: 99%

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The Role of Maternal Factors, Postnatal Nutrition, Weight Gain, and Gender in Regulation of Serum IGF-I among Preterm Infants

et al. 2005

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The Role of Maternal Factors, Postnatal Nutrition, Weight Gain, and Gender in Regulation of Serum IGF-I among Preterm Infants

et al. 2005

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“…Insulin-like growth factor-1 (IGF-1) is the main important hormone that regulates the fetal growth. Fetal IGF-1 concentration is positively correlated with gestational age (Pirazzoli et al, 1997). Moreover, IGF-1 was regulated by glucose level, which is concentration of serum IGF-1 in fasting rat was lower than those in non fasting rat was demonstrated in animal study conducted by Davenport et al (1990).…”

Section: Discussionmentioning

confidence: 84%

Micronutrients Supplementation during Preconception Period Improves Fetal Survival and Cord Blood Insulin-Like Growth Factor 1

Sumarmi¹,

Wirjatmadi²,

Kuntoro³

et al. 2015

Asian J. of Clinical Nutrition

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The objective of this study was to evaluate the efficacy of multi-micronutrients (MMN) supplementation during preconception period on improving fetal survival and concentration of umbilical cord Insulin-like Growth Factor 1 (IGF-1). A randomized double blind community based trial had been conducted. Study subjects were randomly assigned into two groups (n = 210 in each group), namely multi-micronutrient group (MMN group) and placebo-iron folic acid group (Placebo-IFA group). The MMN group received capsule of multi-micronutrients containing 15 micronutrients every 2 days during preconception period (2-6 months before pregnancy) and to be continued with daily dose during pregnancy. Placebo-IFA group received placebo capsule every 2 days during preconception period (2-6 months before pregnancy) and to be continued with daily dose of iron and folic acid during pregnancy. Four hundred twenty eligible subjects were enrolled to meet approximately 115 babies born. The outcome variables were fetal survival and concentration of serum umbilical cord IGF-1. Data were analyzed using independent t-test to compare mean difference between MMN group and Placebo-IFA group and chi-square was used for dichotomous data to analyzed odd ratio. Results demonstrated significant difference of fetal survival (gestation age >37 weeks) between MMN group and Placebo-IFA group (p = 0.003). Fetuses in MMN group were more likely to survive than those in Placebo-IFA group (OR = 6,099; 95% CI: 0.934-39.847). ). These findings imply that MMN supplementation prior to pregnancy is very important to support intra uterine environment in early pregnancy for successful complete gestation period.

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“…support that IGF systems play a major role in antenatal/ postnatal growth (7,13). Taken together, it is most likely that loss of one copy of IGF-IR is involved in the pathophysiology of the present case.…”

mentioning

confidence: 79%

IGF-Related Proteins at Birth in a Case of Antenatally Diagnosed Silver-Russell Syndrome

et al. 2002

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Developmental pattern of fetal growth hormone, insulin-like growth factor I, growth hormone binding protein and insulin-like growth factor binding protein-3

Cited by 15 publications

References 36 publications

The Role of Maternal Factors, Postnatal Nutrition, Weight Gain, and Gender in Regulation of Serum IGF-I among Preterm Infants

The Role of Maternal Factors, Postnatal Nutrition, Weight Gain, and Gender in Regulation of Serum IGF-I among Preterm Infants

Micronutrients Supplementation during Preconception Period Improves Fetal Survival and Cord Blood Insulin-Like Growth Factor 1

IGF-Related Proteins at Birth in a Case of Antenatally Diagnosed Silver-Russell Syndrome

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