Developmental aspects of timing behavior in children

Chelonis, John J.; Flake, Rebecca A.; Baldwin, Ronald L.; Blake, Donna Jo; Paule, Merle G.

doi:10.1016/j.ntt.2004.01.004

Cited by 40 publications

(21 citation statements)

References 75 publications

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“…In experiments using perinatal exposure, changes in the mother, such as weight loss or changes in maternal homeostasis, may interfere indirectly with the development of offspring [30][31][32][33]. The nonoccurrence of maternal toxicity seen in present experiment indicates that any change occurring with the offspring' was therefore exclusively due to exposure to fipronil.…”

Section: Discussionmentioning

confidence: 57%

“…According to previous literature data exposure to pesticides during pregnancy and lactation can cause changes reflected in physical and behavioral offspring aspects, according to the period of animal development [33,34]. Perinatal exposure may involve latent effects which are only observed later, even in cases in which exposure occurs at doses below those which promote evident effects in adults [35].…”

Section: Discussionmentioning

confidence: 99%

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Lactational Exposure to Fipronil Pesticide in Low Dose Impairs Memory in Rat Offspring

Montanha¹,

Machado²

2016

J Neurol Disord

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Perinatal exposure to pesticides has been associated with neurotoxic changes that may occur during offspring development. This work aimed to evaluate the memory behavior in young and adult offspring from Wistar rats exposed to fipronil in the lactational period. For this, pregnant rats were distributed into two groups (N = 15) constituted as follows: control (Ct) and exposed to fipronil (Fip). Fipronil (Topline®) was administrated to mothers topically, at dose of 1 mg/kg/day, from the 7-14th day of lactation. The offspring memory behavior was assessed using the new object recognition task (ORT) and eight-radial arm maze task (8-RAM). Additionally was quantified the activity of the acetylcholinesterase enzyme (AChE) and made histopathological analysis of brain tissue. Results show persistent decreased memory behavior in offspring exposed to fipronil during lactation period associated with altered AChE activity and morphological changes in the animal's brain tissue. It is concluded that lactational exposure to fipronil provoked damage to the central nervous system (CNS) including altered memory behavior with histopathological and biochemical changes.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Lactational Exposure to Fipronil Pesticide in Low Dose Impairs Memory in Rat Offspring

Montanha¹,

Machado²

2016

J Neurol Disord

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“…The similarity in OTB performance between monkeys and children 49,51,52 is of particular importance with regard to extrapolating to humans the neurobehavioral (and possibly neurotoxic) effects of drugs and toxicants as determined in the monkey model. Additionally, the demonstration that several measures of OTB performance correlate highly with measures of intelligence in children 40-42,44 serves to highlight the relevance of such measures.…”

Section: Methodsmentioning

confidence: 99%

Neurodevelopment of children exposed to anesthesia: Design of the Mayo Anesthesia Safety in Kids (MASK) study

Gleich

Flick

et al. 2015

Contemporary Clinical Trials

102

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There is increasing evidence that exposure of developing brains in animals, including nonhuman primates, to commonly-utilized anesthetic agents may cause adverse effects on cognition and behavior. In this paper, we summarize our methodology for a population-based, propensity-matched study to evaluate possible anesthesia-related sequelae in preschool children when evaluated in elementary or high school. A cohort of all children born in Olmsted County, Minnesota between the years 1994-2007 who are currently local residents has been identified. Existing medical records are being used to identify all episodes of exposure to general anesthesia prior to the age of 3 years (i.e., prior to their 3rd birthday). Children with multiple, single, and no anesthesia exposure are sampled for testing between the ages of 8-12 years or 15-19 years during the period 2012-2016. To match children in different exposure groups as closely as possible, sampling is guided by propensity-matching for the likelihood of receiving anesthesia. Selected children are invited to participate in a single 4-hour session of neuropsychological testing, including the National Center for Toxicological Research-Operant Test Battery, which has been used to study anesthetic neurotoxicity in nonhuman primates. The results of this testing will be compared among children with different anesthetic exposure histories. The expected products of this research will be a detailed phenotype of possible anesthetic-associated neurotoxicity in humans, utilizing a robust patient database and neuropsychological testing battery, and the first comparison of effects of anesthetic exposure in children and nonhuman primates performing nearly identical behavioral tasks.

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“…Subjects interact with press-plates and response levers to indicate choices in tasks governed by specific rules that are dependent upon the specific brain function to be assessed. Importantly, the very same apparatus and tasks can be used with human subjects: in animals, correct responses are reinforced with food pellets and in humans they are typically reinforced with money (nickels; e.g., Chelonis et al, 2000; 2002; 2004; 2011), although candy seems to work fine as well (Daniels-Shaw et al, 2001). …”

Section: Behavioral Toxicologymentioning

confidence: 99%

Behavioral toxicology of cognition: Extrapolation from experimental animal models to humans

Paule

Green

Myerson

et al. 2012

Neurotoxicology and Teratology

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A variety of behavioral instruments are available for assessing important aspects of cognition in both animals and humans and, in many cases, the same instruments can be used in both. While nonhuman primates are phylogenetically closest to humans, rodents, pigeons and other animals also offer behaviors worthy of note. Delay Discounting procedures are as useful as any in studies of impulsivity and may have utility in shedding light on processes associated with drug abuse. Specific memory tests such as Visual Paired Comparisons tasks (similar to the Fagan test of infant intelligence) can be modified to allow for assessment of different aspects of memory such as spatial memory. Use of these and other specific memory tasks can be used to directly monitor aspects of cognitive development in infant animals, particularly in nonhuman primates such as monkeys, and children and to draw inferences with respect to possible neuroanatomical substrates sub-serving their functions. Tasks for assessing working memory such as Variable Delayed Response (VDR), modified VDR and Spatial Working Memory tasks are now known to be affected in Parkinson’s disease (PD). These and other cognitive function tasks are being used in a monkey model of PD to assess the ability of anti-Parkinson’s disease therapies to ameliorate these cognitive deficits without diminishing their therapeutic effects on motor dysfunction. Similarly, in a rat model of the cognitive deficits associated with perinatal exposure to polychlorinated biphenyls (PCBs), clear parallels with children can be seen in at least two areas of executive function: cognitive flexibility and response inhibition. In the rat model, discrimination reversal tasks were utilized to assess cognitive flexibility, a function often assessed in humans using the Wisconsin Card Sorting Task. Response inhibition was assessed using performance in a Differential Reinforcement of Low Response Rates (DRL) task. As the data continue to accumulate, it becomes more clear that our attempts to adapt animal-appropriate tasks for the study of important aspects of human cognition have proven to be very fruitful.

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Developmental aspects of timing behavior in children

Cited by 40 publications

References 75 publications

Lactational Exposure to Fipronil Pesticide in Low Dose Impairs Memory in Rat Offspring

Lactational Exposure to Fipronil Pesticide in Low Dose Impairs Memory in Rat Offspring

Neurodevelopment of children exposed to anesthesia: Design of the Mayo Anesthesia Safety in Kids (MASK) study

Behavioral toxicology of cognition: Extrapolation from experimental animal models to humans

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