Development of trans-Ferulic acid niosome: An optimization and an in-vivo study

Rezaeiroshan, Anahita; Saeedi, Majid; Morteza‐Semnani, Katayoun; Âkbari, Jafar; Gahsemi, Maryam; Nokhodchi, Ali

doi:10.1016/j.jddst.2020.101854

Cited by 19 publications

(8 citation statements)

References 36 publications

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“…Since different variables may have impacts on the responses and also in conventional methods, the influence of each variable on each response is not usually considered, and the application of RSM is necessary. This method is aimed at decreasing the total experiments required for the study while enhancing the results by involving a variety of variables and investigating their impact on the selected responses [ 37 ]. RSM has a variety of experimental designs such as a three-level factorial design, Box-Behnken design, central composite design, and Doehlert design [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

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Hyaluronic Acid‐Coated Chitosan/Gelatin Nanoparticles as a New Strategy for Topical Delivery of Metformin in Melanoma

Ebrahimnejad,

Rezaeiroshan,

Babaei

et al. 2023

BioMed Research International

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Metformin is a multipotential compound for treating diabetes II and controlling hormonal acne and skin cancer. This study was designed to enhance metformin skin penetration in melanoma using nanoparticles containing biocompatible polymers. Formulations with various concentrations of chitosan, hyaluronic acid, and sodium tripolyphosphate were fabricated using an ionic gelation technique tailored by the Box-Behnken design. The optimal formulation was selected based on the smallest particle size and the highest entrapment efficiency (EE%) and used in ex vivo skin penetration study. In vitro antiproliferation activity and apoptotic effects of formulations were evaluated using MTT and flow cytometric assays, respectively. The optimized formulation had an average size, zeta potential, EE%, and polydispersity index of 329 ± 6.30 nm, 21.94 ± 0.05 mV, 64.71 ± 6.12 % , and 0.272 ± 0.010 , respectively. The release profile of the optimized formulation displayed a biphasic trend, characterized by an early burst release, continued by a slow and sustained release compared to free metformin. The ex vivo skin absorption exhibited 1142.5 ± 156.3 μg/cm2 of metformin deposited in the skin layers for the optimized formulation compared to 603.2 ± 93.1 μg/cm2 for the free metformin. Differential scanning calorimetry confirmed the deformation of the drug from the crystal structure to an amorphous state. The attenuated total reflection Fourier transform infrared results approved no chemical interaction between the drug and other ingredients of the formulations. According to the MTT assay, metformin in nanoformulation exhibited a higher cytotoxic effect against melanoma cancer cells than free metformin (IC50: 3.94 ± 0.57 mM vs. 7.63 ± 0.26 mM, respectively, P < 0.001 ). The results proved that the optimized formulation of metformin could efficiently decrease cell proliferation by promoting apoptosis, thus providing a promising strategy for melanoma therapy.

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Section: Resultsmentioning

confidence: 99%

“…At predetermined times (0.5, 1.5, 3, 6, 12, and 24 h), 2 ml of the receptor medium was collected and quantified using a UV spectrophotometer. The same volume of the fresh medium was returned to the cell [ 37 ]. As a blank for each experiment, three Franz cells were placed.…”

Section: Methodsmentioning

confidence: 99%

Hyaluronic Acid‐Coated Chitosan/Gelatin Nanoparticles as a New Strategy for Topical Delivery of Metformin in Melanoma

Ebrahimnejad,

Rezaeiroshan,

Babaei

et al. 2023

BioMed Research International

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“…A new way to improve the deficiency of phenolic acids is using a vesicular drug delivery system. Rezaeiroshan et al [ 83 ] designed and prepared niosomes—the vesicles composed of non-ionic surfactants. Recent developments in therapeutic and nutraceutical applications of p-methoxycinnamic acid from plant origin formulations with ferulic acid.…”

Section: Novel Strategies For Ferulic Acid Drug Deliverymentioning

confidence: 99%

Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid

Stompor-Gorący

Machaczka

2021

IJMS

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Trans-ferulic acid (FA) is a derivative of 4-hydroxycinnamic acid, which is found in many food products, fruits and beverages. It has scientifically proven antioxidant, anti-inflammatory and antibacterial properties. However, its low ability to permeate through biological barriers (e.g., the blood–brain barrier, BBB), its low bioavailability and its fast elimination from the gastrointestinal tract after oral administration limit its clinical use, e.g., for the treatment of neurodegenerative diseases, such as Alzheimer’s disease. Therefore, new nanotechnological approaches are developed in order to regulate intracellular transport of ferulic acid. The objective of this review is to summarize the last decade’s research on biological properties of ferulic acid and innovative ways of its delivery, supporting pharmacological therapy.

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“…Niosomal vesicles were prepared by film hydration method, which is explained in our previous paper [10]. As the aim of the current study was to investigate the antioxidant effect of the obtained niosomes, therefore, further details of making niosomes were not reported here.…”

Section: Niosome Preparation and Characterizationmentioning

confidence: 99%

“…Cholesterol is used to avoid the probable leakage through the vesicle and it is usually known as the hardener of the structure. For further information, the authors suggest readers refer to our published paper [10]. SEM images are shown in Fig.…”

Section: Tfa Niosome Characterization and Morphology Evaluationmentioning

confidence: 99%

Vesicular Formation of Trans-Ferulic Acid: an Efficient Approach to Improve the Radical Scavenging and Antimicrobial Properties

et al. 2021

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Purposes Reactive oxygen species production is harmful to human’s health. The presence of antioxidants in the body may help to diminish reactive oxygen species. Trans-ferulic acid is a good antioxidant, but its low water solubility excludes its utilization. The study aims to explore whether a vesicular drug delivery could be a way to overcome the poor absorption of trans-ferulic acid hence improving its antimicrobial efficiency and antioxidant effect. Methods Niosomal vesicles containing the drug were prepared by film hydration method. The obtained vesicles were investigated in terms of morphology, size, entrapment efficiency, release behavior, cellular cytotoxicity, antioxidant, cellular protection study, and antimicrobial evaluations. Results The optimized niosomal formulation had a particle size of 158.7 nm and entrapment efficiency of 21.64%. The results showed that the optimized formulation containing 25 μM of trans-ferulic acid could enhance the viability of human foreskin fibroblast HFF cell line against reactive oxygen species production. The minimum effective dose of the plain drug and the niosomal formulation against Staphylococcus aurous (ATCC 29213) was 750 µg/mL and 375 µg/mL, respectively, and for Escherichia coli (ATCC 25922), it was 750 µg/mL and 187/5 µg/mL, respectively. The formulation could also improve the minimum bactericidal concentration of the drug in Staphylococcus aurous, Escherichia coli, and Acinobacter baumannii (ATCC 19606). Conclusion These results revealed an improvement in both antibacterial and antioxidant effects of the drug in the niosomal formulation.

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Development of trans-Ferulic acid niosome: An optimization and an in-vivo study

Cited by 19 publications

References 36 publications

Hyaluronic Acid‐Coated Chitosan/Gelatin Nanoparticles as a New Strategy for Topical Delivery of Metformin in Melanoma

Hyaluronic Acid‐Coated Chitosan/Gelatin Nanoparticles as a New Strategy for Topical Delivery of Metformin in Melanoma

Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid

Vesicular Formation of Trans-Ferulic Acid: an Efficient Approach to Improve the Radical Scavenging and Antimicrobial Properties

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