Development of three-dimensional bacterial cellulose/chitosan scaffolds: Analysis of cell-scaffold interaction for potential application in the diagnosis of ovarian cancer

Ul‐Islam, Mazhar; Subhan, Fazli; Islam, Salman Ul; Khan, Shaukat; Shah, Nasrullah; Manan, Sehrish; Ullah, Muhammad Wajid; Yang, Guang

doi:10.1016/j.ijbiomac.2019.07.050

Cited by 80 publications

(54 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to this, it is possible that a certain degree of penetration of the cells into the polymer matrix occurred. Previous works evidenced in fact the ability of BC to support the infiltration of cells throughout the third dimension of the scaffold, in a proportional manner with respect to the cells size and the pore size of the nanofibrillar structure (Luo et al, 2019;Ul-Islam et al, 2019b).…”

Section: Discussionmentioning

confidence: 98%

Chemical Modification of Bacterial Cellulose for the Development of an Antibacterial Wound Dressing

Orlando

Basnett

Nigmatullin

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Chemical Modification of Bacterial Cellulose for the Development of an Antibacterial Wound Dressing

Orlando

Basnett

Nigmatullin

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…The thermal stability of the scaffold was also significantly improved. Other studies have concluded that using nanocellulose based scaffolds have better cell attachment due to the enhancement of physical and mechanical properties, which mainly affect the cell-scaffold interaction [158,159]. Novel polymer ternary blend scaffolds have been fabricated by Ninan et al [160] to culture fibroblast cells.…”

Section: Physical Propertiesmentioning

confidence: 99%

“…A significant number of studies have confirmed that cellulose could be generally considered to be biocompatible with only moderate or no foreign body responses in vivo [168,169]. Ul-Islam et al [158] analysed cell-scaffold interaction using a cancer cell line and cellulose/chitosan scaffolds. Strong adhesion and negligible aggregation of cancer cell lines were reported in the scaffold matrix and better cell-scaffold interaction than cell-cell interaction [158].…”

Section: Biocompatibility and Cytotoxicitymentioning

confidence: 99%

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

et al. 2020

View full text Add to dashboard Cite

Biopolymers have been used as a replacement material for synthetic polymers in scaffold forming due to its biocompatibility and nontoxic properties. Production of scaffold for tissue repair is a major part of tissue engineering. Tissue engineering techniques for scaffold forming with cellulose-based material is at the forefront of present-day research. Micro- and nanocellulose-based materials are at the forefront of scientific development in the areas of biomedical engineering. Cellulose in scaffold forming has attracted a lot of attention because of its availability and toxicity properties. The discovery of nanocellulose has further improved the usability of cellulose as a reinforcement in biopolymers intended for scaffold fabrication. Its unique physical, chemical, mechanical, and biological properties offer some important advantages over synthetic polymer materials. This review presents a critical overview of micro- and nanoscale cellulose-based materials used for scaffold preparation. It also analyses the relationship between the method of fabrication and properties of the fabricated scaffold. The review concludes with future potential research on cellulose micro- and nano-based scaffolds. The review provides an up-to-date summary of the status and future prospective applications of micro- and nanocellulose-based scaffolds for tissue engineering.

show abstract

“…Furthermore, a study reported that bacterial cellulose and chitosan scaffold can be used in the ovarian cancer diagnosis as it has multiple advantages, such as biocompatibility, nontoxicity, and a three‐dimensional (3D) structure. Findings showed that A2780 (ovarian cancer cell line) had a strong interaction with this scaffold and infiltrated into that scaffold deeply …”

Section: Applications Of Chitosan In the Diagnosis Of Ovarian Cancer mentioning

confidence: 99%

Chitosan is a potential inhibitor of ovarian cancer: Molecular aspects

et al. 2019

View full text Add to dashboard Cite

Although ovarian cancer has a lower prevalence than breast cancer, its mortality rate is three times higher, which is reported to increase in the coming years. As the early stages of ovarian cancer do not have any obvious symptoms, in most of the cases, this cancer is diagnosed at advanced stages with a poor prognosis. Moreover, in many patients who are diagnosed with advanced stage, relapse of the disease and drug resistance are observed. Over the past years, these women have been treated with chemotherapy and cytoreductive surgeries. However, the chemotherapy could affect the healthy tissues in addition to the malignancies. Therefore, discovering new diagnostic and therapeutic options seems to be a crucial need. Unlike the common invasive and/or nonspecific treatments, nanomedicine is trying to find a new way for cancer imaging, diagnosis, and drug delivery method. Nanoparticles (NPs), which has recently drawn attention, can be used in order to reduce the toxicity and frequent dosing of drugs, tumor‐specific delivery, and early diagnosis for malignancies. Chitosan as an NP and product of chitin deacetylation has multiple characteristics, including biocompatibility, biodegradability, and safety. In this review, we cover the studies concerned with the role of chitosan in finding solutions to overcome the problems faced in ovarian cancer treatments. Furthermore, we highlight how chitosan is being used in delivering chemotherapy drugs, gene therapy, and imaging methods for both detection and image‐guided therapies.

show abstract

Development of three-dimensional bacterial cellulose/chitosan scaffolds: Analysis of cell-scaffold interaction for potential application in the diagnosis of ovarian cancer

Cited by 80 publications

References 46 publications

Chemical Modification of Bacterial Cellulose for the Development of an Antibacterial Wound Dressing

Chemical Modification of Bacterial Cellulose for the Development of an Antibacterial Wound Dressing

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

Chitosan is a potential inhibitor of ovarian cancer: Molecular aspects

Contact Info

Product

Resources

About