Chemical Modification of Bacterial Cellulose for the Development of an Antibacterial Wound Dressing

Orlando, Isabel; Basnett, Pooja; Nigmatullin, Rinat; Wang, Wenxin; Knowles, Jonathan C.; Roy, Ipsita

doi:10.3389/fbioe.2020.557885

Cited by 62 publications

(44 citation statements)

References 99 publications

(107 reference statements)

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“…On the way towards expanding the scale of BC applications, it is crucial to exploit the unique structure and properties of BC to develop novel BC-based nanomaterials with new features. Various functionalization methods for BC-based materials concentrated on the chemical modification or physical coating [57,58]. The macromolecular structure of BC can be controlled by traditional approaches such as the change of cultivation strategy, type of strain, carbon source, and additives [59,60].…”

Section: Product Levelmentioning

confidence: 99%

Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels

Buldum

Mantalaris

2021

IJMS

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Engineering biological processes has become a standard approach to produce various commercially valuable chemicals, therapeutics, and biomaterials. Among these products, bacterial cellulose represents major advances to biomedical and healthcare applications. In comparison to properties of plant cellulose, bacterial cellulose (BC) shows distinctive characteristics such as a high purity, high water retention, and biocompatibility. However, low product yield and extensive cultivation times have been the main challenges in the large-scale production of BC. For decades, studies focused on optimization of cellulose production through modification of culturing strategies and conditions. With an increasing demand for BC, researchers are now exploring to improve BC production and functionality at different categories: genetic, bioprocess, and product levels as well as model driven approaches targeting each of these categories. This comprehensive review discusses the progress in BC platforms categorizing the most recent advancements under different research focuses and provides systematic understanding of the progress in BC biosynthesis. The aim of this review is to present the potential of ‘modern genetic engineering tools’ and ‘model-driven approaches’ on improving the yield of BC, altering the properties, and adding new functionality. We also provide insights for the future perspectives and potential approaches to promote BC use in biomedical applications.

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Section: Product Levelmentioning

confidence: 99%

Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels

Buldum

Mantalaris

2021

IJMS

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“…These simple recognition peptides are easily incorporated into nanoparticles and can be incorporated into oncolytic viruses and bacteria through genetic modification techniques. Thus, targeting integrins overexpressed or alternatively expressed on the surface of tumorigenic cells represents a feasible strategy for all three modalities of drug delivery discussed within this review [231][232][233][234][235][247][248][249][250][251].…”

Section: Cell Surface Moleculesmentioning

confidence: 99%

“…However, synthetic biology mechanisms can be applied to accomplish genetic modification of organisms to produce nanoparticles, especially exosomes. It is worth noting that most bacterial cell surfaces are charged; therefore, chemical modifications are generally relatively easy [248], nor is using biopolymers or enzymes secreted by oncolytic bacteria as indirect therapeutics [249].…”

Section: Modification and Characterization Of Novel Therapeuticsmentioning

confidence: 99%

The Evolution and Future of Targeted Cancer Therapy: From Nanoparticles, Oncolytic Viruses, and Oncolytic Bacteria to the Treatment of Solid Tumors

et al. 2021

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While many classes of chemotherapeutic agents exist to treat solid tumors, few can generate a lasting response without substantial off-target toxicity despite significant scientific advancements and investments. In this review, the paths of development for nanoparticles, oncolytic viruses, and oncolytic bacteria over the last 20 years of research towards clinical translation and acceptance as novel cancer therapeutics are compared. Novel nanoparticle, oncolytic virus, and oncolytic bacteria therapies all start with a common goal of accomplishing therapeutic drug activity or delivery to a specific site while avoiding off-target effects, with overlapping methodology between all three modalities. Indeed, the degree of overlap is substantial enough that breakthroughs in one therapeutic could have considerable implications on the progression of the other two. Each oncotherapeutic modality has accomplished clinical translation, successfully overcoming the potential pitfalls promising therapeutics face. However, once studies enter clinical trials, the data all but disappears, leaving pre-clinical researchers largely in the dark. Overall, the creativity, flexibility, and innovation of these modalities for solid tumor treatments are greatly encouraging, and usher in a new age of pharmaceutical development.

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“…Several studies have proposed the use of BC with other polymers or molecules, resulting in the development of a new material with optimized properties aimed at its application as a wound dressing, through the addition of silver nanoparticles [ 27 ], chitosan [ 28 ], zinc oxide [ 29 ], titanium dioxide [ 30 ], collagen [ 31 ], and starch [ 32 ]. Recent studies have shown that the changes in the physical structure of BC using chemical modifiers improve the biological properties of the biomaterial, confirming its potential as an alternative material to develop an environmentally-friendly and biocompatible wound dressing, which promotes tissue regeneration [ 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Bacterial Cellulose Biocomposites Combined with Starch and Collagen and Evaluation of Their Properties

et al. 2021

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One of the major benefits of biomedicine is the use of biocomposites as wound dressings to help improve the treatment of injuries. Therefore, the main objective of this study was to develop and characterize biocomposites based on bacterial cellulose (BC) with different concentrations of collagen and starch and characterize their thermal, morphological, mechanical, physical, and barrier properties. In total, nine samples were produced with fixed amounts of glycerol and BC and variations in the amount of collagen and starch. The water activity (0.400–0.480), water solubility (12.94–69.7%), moisture (10.75–20.60%), thickness (0.04–0.11 mm), water vapor permeability (5.59–14.06 × 10−8 g·mm/m2·h·Pa), grammage (8.91–39.58 g·cm−2), opacity (8.37–36.67 Abs 600 nm·mm−1), elongation (4.81–169.54%), and tensile strength (0.99–16.32 MPa) were evaluated and defined. In addition, scanning electron microscopy showed that adding biopolymers in the cellulose matrix made the surface compact, which also influenced the visual appearance. Thus, the performance of the biocomposites was directly influenced by their composition. The performance of the different samples obtained resulted in them having different potentials for application considering the injury type. This provides a solution for the ineffectiveness of traditional dressings, which is one of the great problems of the biomedical sector.

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Chemical Modification of Bacterial Cellulose for the Development of an Antibacterial Wound Dressing

Cited by 62 publications

References 99 publications

Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels

Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels

The Evolution and Future of Targeted Cancer Therapy: From Nanoparticles, Oncolytic Viruses, and Oncolytic Bacteria to the Treatment of Solid Tumors

Development of Bacterial Cellulose Biocomposites Combined with Starch and Collagen and Evaluation of Their Properties

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