Development of Thiadiazole as an Antidiabetic Agent- A Review

Abstract

This review provides a brief summary of thiadiazole ring containing compounds as antidiabetic agents. It covers the most active thiadiazole derivatives selected from reported literature of thiadiazole system as antidiabetic drug substance in the form of synthesis and structural activity relationship study reports. Some of the promising thiadiazole compounds interacting with targets such as sodium-glucose linked transporter, peroxisome proliferator-activated receptor, protein tyrosine phosphatase, c-Jun N-terminal kinase, dipeptidyl peptidase-4 and cannabinoid-1 receptor have been collected with their biological potency. The information provided in this review acts as important overview for medicinal chemist to develop a new chemical entity possessing antidiabetic activity.

Chemistry, synthesis and progress report on biological activities of thiadiazole compounds - a review

“…Thiosemicarbazide cyclizes directly to 2-amino-5-methyl-1,3,4-thiadiazole with acetyl chloride. This simple route to 2-amino 5-substituted-1,3,4-thiadiazole seems to be quite general 18 . In the example shown R may be methyl 18 , norhydnocarpyl 19 , benzyl 20 , cyclopropyl 21 and many others.…”

“…They have known to exhibit diverse biological activities such as in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities 3 . New acylated 5-thio-beta-D-glucopyranosylimino-disusbstituted 1,3,4-thiadiazoles prepared by cycloaddition of the glycosyl isothiocyanate with the reactive intermediates 1-aza-2-azoniaallene hexachloro antimonates, and have been tested in vitro antiviral activity against HIV-1, HIV-2, human cytomegallovirus (HMCV) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] .…”

Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes

“…14 Consequently, JNK inhibitors are generally considered as potential antidiabetic agents. 15,16 JNK as a member of MAPK family also controls cell proliferation, survival and DNA repair through phosphorylating a wide array of transcription factors (e.g. c-Jun, p53).…”

“…19 The best known representative of this compound family is pazopanib, a multitarget receptor tyrosine kinase inhibitor, which acts against renal cell carcinoma and soft tissue sarcoma via inhibition of angiogenesis. 16 Around 32 000 compounds can be found in SciFinder having bisphenylamino pyrimidine core structure, and 610 biological activity values were published in 1776 publications, including 353 review articles. These data show that the chemical space is well covered for this core structure.…”

Design and Development of Novel Pyrazole-Thiadiazole Derivatives as NF-ĸB Inhibitor and Cardioprotective Effect against Isoproterenol Induced Myocardial Infarction in Sprague-Dawley Rats

“…Thiadiazole is a well-known pharmacophore endowed with diverse pharmacological activities such as antibacterial [13,14], antifungal [15], anticancer [16], antimalarial [17], and anti antidiabetic [18]. On the contrary, pyrazole is also reported to be present in many active pharmaceutical agents displaying myriad activities such as antioxidant [19,20], antimycobacterial [21], antiviral [22,23], anticonvulsant [24], and antibacterial [25].…”