Development of theranostic wound dressings: harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers

Saberianpour, Shirin; Melotto, Gianluca; Forss, Rachel; Redhead, Lucy; Elsom, Jacqueline; Terrazzini, Nadia; Sandeman, Susan; Sarker, Dipak K.; Bucca, Giselda; Hesketh, Andrew; Crua, Cyril; Santin, Matteo

doi:10.1080/17434440.2023.2181694

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…At specified intervals, the samples were removed, excess water was absorbed with filter paper from the surface and then weighed. Equation (2) has been used to determine the degree of swelling:…”

Section: Determination Of the Degree Of Gel Swellingmentioning

confidence: 99%

“…Wound healing is a dynamic process that depends on the patient's health status. Traditional wound dressings use a passive approach and aim to create a suitable environment for the healing process [1,2]. The current understanding of restoration without leaving a scar is for a breathable dressing that creates a clean, moist, and warm environment.…”

Section: Introductionmentioning

confidence: 99%

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Fluorescent Composite Cotton Fabric Modified with Crosslinked Chitosan for Theranostic Applications

Staneva,

Atanasova,

Grabchev

2023

Applied Sciences

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Developing multifunctional textile material for wound dressing is challenging due to the variety of wounds and their differing healing stages. Therefore, theranostics replaces the traditional approach to provide patient comfort and accelerated healing. In this study, we developed and compared three different materials. For this purpose, for the first time, chitosan was modified with 4-nitro-1,8-naphthalic anhydride in N,N-dimethylformamide (DMF) suspension, and subsequent nucleophilic substitution of the nitro group with N,N-dimethylamino group, whereby chitosan with a yellow color and fluorescence was obtained. Cotton fabric was impregnated successively with a citric acid solution and solution from chitosan and chitosan modified with 1,8-naphthalimide fluorophore (CN material). The same experimental protocol was applied for the second material, but indomethacin was added to the chitosan solution (CNI material). The third material was prepared similarly to the second but was immersed in an alginate solution as a last step (CNIA material). The obtained materials have been characterized by optical and scanning electron microscopy and thermal analysis (TG-DTA-DTG). Indomethacin release from composite materials and hydrogel swelling and erosion in phosphate buffer pH 7.4 at 37 °C was examined using gravimetric analysis, UV-vis absorption, and fluorescence spectroscopy. The antimicrobial activity of the cotton samples has been evaluated against B. cereus and P. aeruginosa as model bacterial strains. The analysis showed that CN material inhibited about 98.8% of the growth of P. aeruginosa and about 95.5% of the growth of B. cereus. Other composite materials combine antimicrobial properties with a sustained release of biologically active substances that can observed visually.

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Section: Determination Of the Degree Of Gel Swellingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fluorescent Composite Cotton Fabric Modified with Crosslinked Chitosan for Theranostic Applications

Staneva,

Atanasova,

Grabchev

2023

Applied Sciences

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Innovative approaches to wound healing: insights into interactive dressings and future directions

Yadav,

Kumar,

Kathpalia

et al. 2024

J. Mater. Chem. B

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Innovative Approach to Accelerate Wound Healing: Synthesis and Validation of Enzymatically Cross-linked COL-rGO-PDA Biocomposite Hydrogels

González,

Espinoza,

Tapia

et al. 2024

Preprint

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In this study, an innovative conductive hybrid biomaterial was synthetized using collagen and reduced graphene oxide (rGO) in order to be used as wound dressing. The collagen hydrogels (COL) were plasticized with glycerol and enzymatically cross-linked with horseradish peroxidase (HRP). A successful interaction among the components was demonstrated by FTIR, XRD, and XPS. It was demonstrated that increasing the rGO concentration led to higher conductivity and negative charge density values. Moreover, rGO also improved the stability of hydrogels which has expressed by a reduction of the biodegradation rate. Furthermore, the hydrogel’s stability, against the enzymatic action of collagenase type I, was also strengthened by both the enzymatic cross-linking and the polymerization of dopamine. However, their absorption capacity, reaching values of 215 g/g, indicates the high potential of the hydrogels to absorb fluids. The rise of these properties positively influenced the wound closure process, achieving an 84.5% in vitro closure rate after 48 h. These findings clearly demonstrate that these original composite biomaterials can be a viable choice for wound healing purposes.

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Development of theranostic wound dressings: harnessing the knowledge of biospecific interactions at the biomaterial interface to promote healing and identify biomarkers

Cited by 5 publications

References 15 publications

Fluorescent Composite Cotton Fabric Modified with Crosslinked Chitosan for Theranostic Applications

Fluorescent Composite Cotton Fabric Modified with Crosslinked Chitosan for Theranostic Applications

Innovative approaches to wound healing: insights into interactive dressings and future directions

Innovative Approach to Accelerate Wound Healing: Synthesis and Validation of Enzymatically Cross-linked COL-rGO-PDA Biocomposite Hydrogels

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